Spontaneous activation of the first component of human complement (C1) by an intramolecular autocatalytic mechanism

For biochemical characterization, the first component of human complement (C1) was reconstituted from physiologic concentrations of purified C1q, 125I C1r, and 131I C1s. Upon incubation at 37 degrees C, C1 spontaneously activated, as evidenced by the characteristic proteolysis of the C1r and C1s pol...

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Veröffentlicht in:	The Journal of immunology (1950) 1982-06, Vol.128 (6), p.2500-2504
1. Verfasser:	Ziccardi, RJ
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Benzoates - pharmacology Biological and medical sciences Catalysis Cell interactions Complement Activating Enzymes Complement Activation Complement C1 - metabolism Complement C1q Complement C1r Complement C1s Fundamental and applied biological sciences. Psychology Fundamental immunology Guanidines - pharmacology Humans Immunobiology Kinetics Macromolecular Substances Phenylmethylsulfonyl Fluoride - pharmacology Protease Inhibitors - pharmacology Temperature Time Factors
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