Influence of Sulfhydryl Reagents and Heavy Metals on the Functional State of the Muscarinic Acetylcholine Receptor in Rat Brain

Membranes from rat brain contain several groups that react with sulfhydryl reagents to influence muscarinic acetylcholine receptor binding. p -Chloromercuribenzoate (PCMB) reacts with a group(s) within or under the allosteric control of the receptor binding site to inhibit both agonist and antagonis...

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Veröffentlicht in:	Molecular pharmacology 1978-07, Vol.14 (4), p.575-586
Hauptverfasser:	Aronstam, R S, Abood, L G, Hoss, W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - drug effects Ethylmaleimide - pharmacology Kinetics Membranes - drug effects Mercuribenzoates - pharmacology Metals - pharmacology Rats Receptors, Cholinergic - drug effects Receptors, Muscarinic - drug effects Sulfhydryl Reagents - pharmacology
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