NEW ANTHRACYCLINE GLYCOSIDES: 4-O-DEMETHYL-11-DEOXYDOXORUBICIN AND ANALOGUES FROM STREPTOMYCES PEUCETIUS VAR. AUREUS

The new anthracyclines 4-O-demethyl-11-deoxydoxorubicin, 4-O-demethyl-11-deoxydaunorubicin along with its 13-dihydro and 13-deoxo analogues are the main components of the anthracycline complex produced by cultures of Streptomyces peucetius var. aureus. They were isolated by solvent partition, separa...

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Veröffentlicht in:	Journal of antibiotics 1982, Vol.35(2), pp.176-183
Hauptverfasser:	CASSINELLI, GIUSEPPE, RIVOLA, GIOVANNI, RUGGIERI, DANIELA, ARCAMONE, FEDERICO, GREIN, ARPAD, MERLI, SERGIO, SPALLA, CELESTINO, CASAZZA, ANNA MARIA, MARCO, AURELIO DI, PRATESI, GRAZIELLA
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - isolation & purification Antibiotics, Antineoplastic - pharmacology Bacteria - drug effects Chemical Phenomena Chemistry Doxorubicin - analogs & derivatives Doxorubicin - isolation & purification Doxorubicin - pharmacology Fermentation Humans Leukemia L1210 - drug therapy Leukemia P388 - drug therapy Mice Naphthacenes - isolation & purification Naphthacenes - pharmacology Streptomyces - metabolism
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Zusammenfassung:	The new anthracyclines 4-O-demethyl-11-deoxydoxorubicin, 4-O-demethyl-11-deoxydaunorubicin along with its 13-dihydro and 13-deoxo analogues are the main components of the anthracycline complex produced by cultures of Streptomyces peucetius var. aureus. They were isolated by solvent partition, separated by column chromatography and characterized by chemical and physical methods. Among these new anthracyclines, displaying antibacterial and cytotoxic activity "in vitro", 4-O-demethyl-11-deoxydoxorubicin and the corresponding daunorubicin analogue were also active against experimental tumors.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.35.176