Effects of α-adrenoceptor agents on norepinephrine release from vas deferens of several species including man
Unlike the situation with the vas deferens of rats, guinea-pigs, rabbits an dogs, neither phentolamine nor yohimbine enhanced electrically-evoked release of [ 3H]norepinephrine from the in vitro human vas deferens. However, clonidine produced, by a phentolamine-sensitive mechanism, a concentration-r...
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| Veröffentlicht in: | European journal of pharmacology 1982-03, Vol.78 (4), p.487-490 |
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| container_end_page | 490 |
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| container_issue | 4 |
| container_start_page | 487 |
| container_title | European journal of pharmacology |
| container_volume | 78 |
| creator | Belis, John A. Colby, Judith E. Westfall, David P. |
| description | Unlike the situation with the vas deferens of rats, guinea-pigs, rabbits an dogs, neither phentolamine nor yohimbine enhanced electrically-evoked release of [
3H]norepinephrine from the in vitro human vas deferens. However, clonidine produced, by a phentolamine-sensitive mechanism, a concentration-related inhibition of release inthe human vas deferens. The results indicate that, even though presynaptic α-adrenoceptors exist, a negative feedback regulation of release by norepinephrine, which occurs in the vas deferens of the other species, may not be functionally important in the vas deferens of the human. |
| doi_str_mv | 10.1016/0014-2999(82)90495-2 |
| format | Article |
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3H]norepinephrine from the in vitro human vas deferens. However, clonidine produced, by a phentolamine-sensitive mechanism, a concentration-related inhibition of release inthe human vas deferens. The results indicate that, even though presynaptic α-adrenoceptors exist, a negative feedback regulation of release by norepinephrine, which occurs in the vas deferens of the other species, may not be functionally important in the vas deferens of the human.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(82)90495-2</identifier><identifier>PMID: 6122590</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adrenergic alpha-Agonists - pharmacology ; Adrenergic alpha-Antagonists - pharmacology ; Animals ; Clonidine ; Dogs ; Guinea Pigs ; Human vas deferens ; Humans ; In Vitro Techniques ; Male ; Muscle, Smooth - metabolism ; Norepinephrine - metabolism ; Phentolamine ; Phentolamine - pharmacology ; Presynaptic α-receptors ; Rabbits ; Rats ; Rats, Inbred Strains ; Species Specificity ; Swine ; Vas Deferens - metabolism ; Yohimbine</subject><ispartof>European journal of pharmacology, 1982-03, Vol.78 (4), p.487-490</ispartof><rights>1982</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-96eb5395c204faae4023deee50bd63c67ab6f17312206277dc3183952ca86b783</citedby><cites>FETCH-LOGICAL-c357t-96eb5395c204faae4023deee50bd63c67ab6f17312206277dc3183952ca86b783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0014299982904952$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6122590$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Belis, John A.</creatorcontrib><creatorcontrib>Colby, Judith E.</creatorcontrib><creatorcontrib>Westfall, David P.</creatorcontrib><title>Effects of α-adrenoceptor agents on norepinephrine release from vas deferens of several species including man</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>Unlike the situation with the vas deferens of rats, guinea-pigs, rabbits an dogs, neither phentolamine nor yohimbine enhanced electrically-evoked release of [
3H]norepinephrine from the in vitro human vas deferens. However, clonidine produced, by a phentolamine-sensitive mechanism, a concentration-related inhibition of release inthe human vas deferens. The results indicate that, even though presynaptic α-adrenoceptors exist, a negative feedback regulation of release by norepinephrine, which occurs in the vas deferens of the other species, may not be functionally important in the vas deferens of the human.</description><subject>Adrenergic alpha-Agonists - pharmacology</subject><subject>Adrenergic alpha-Antagonists - pharmacology</subject><subject>Animals</subject><subject>Clonidine</subject><subject>Dogs</subject><subject>Guinea Pigs</subject><subject>Human vas deferens</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Muscle, Smooth - metabolism</subject><subject>Norepinephrine - metabolism</subject><subject>Phentolamine</subject><subject>Phentolamine - pharmacology</subject><subject>Presynaptic α-receptors</subject><subject>Rabbits</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Species Specificity</subject><subject>Swine</subject><subject>Vas Deferens - metabolism</subject><subject>Yohimbine</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1qGzEQx0VJcB23b5CCTqE5bCppV6vVJRCM2xQMuaRnoZVGrsKutJFsQx6rL9JnqvxBjr3MHP4fw_wQuqbkjhLafiOENhWTUn7t2K0kjeQV-4DmtBOyIoKyCzR_t3xEVzm_EEK4ZHyGZi1ljEsyR2HlHJhtxtHhv38qbROEaGDaxoT1BsJBCTjEBJMPMP1OZeIEA-gM2KU44r3O2IKDEjy2ZNhD0gPOExgPGftghp31YYNHHT6hS6eHDJ_Pe4F-fV89Lx-r9dOPn8uHdWVqLraVbKHnteSGkcZpDQ1htQUATnrb1qYVum8dFXX5grRMCGtq2hU_M7pre9HVC3Rz6p1SfN1B3qrRZwPDoAPEXVaiIXUJ8mJsTkaTYs4JnJqSH3V6U5SoA2Z1YKgODFXH1BGzYiX25dy_60ew76Ez16Lfn3QoT-49JJULjGDA-lRwKxv9_w_8A1wDjgo</recordid><startdate>19820326</startdate><enddate>19820326</enddate><creator>Belis, John A.</creator><creator>Colby, Judith E.</creator><creator>Westfall, David P.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19820326</creationdate><title>Effects of α-adrenoceptor agents on norepinephrine release from vas deferens of several species including man</title><author>Belis, John A. ; Colby, Judith E. ; Westfall, David P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-96eb5395c204faae4023deee50bd63c67ab6f17312206277dc3183952ca86b783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Adrenergic alpha-Agonists - pharmacology</topic><topic>Adrenergic alpha-Antagonists - pharmacology</topic><topic>Animals</topic><topic>Clonidine</topic><topic>Dogs</topic><topic>Guinea Pigs</topic><topic>Human vas deferens</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Muscle, Smooth - metabolism</topic><topic>Norepinephrine - metabolism</topic><topic>Phentolamine</topic><topic>Phentolamine - pharmacology</topic><topic>Presynaptic α-receptors</topic><topic>Rabbits</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Species Specificity</topic><topic>Swine</topic><topic>Vas Deferens - metabolism</topic><topic>Yohimbine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Belis, John A.</creatorcontrib><creatorcontrib>Colby, Judith E.</creatorcontrib><creatorcontrib>Westfall, David P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Belis, John A.</au><au>Colby, Judith E.</au><au>Westfall, David P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of α-adrenoceptor agents on norepinephrine release from vas deferens of several species including man</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1982-03-26</date><risdate>1982</risdate><volume>78</volume><issue>4</issue><spage>487</spage><epage>490</epage><pages>487-490</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>Unlike the situation with the vas deferens of rats, guinea-pigs, rabbits an dogs, neither phentolamine nor yohimbine enhanced electrically-evoked release of [
3H]norepinephrine from the in vitro human vas deferens. However, clonidine produced, by a phentolamine-sensitive mechanism, a concentration-related inhibition of release inthe human vas deferens. The results indicate that, even though presynaptic α-adrenoceptors exist, a negative feedback regulation of release by norepinephrine, which occurs in the vas deferens of the other species, may not be functionally important in the vas deferens of the human.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>6122590</pmid><doi>10.1016/0014-2999(82)90495-2</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0014-2999 |
| ispartof | European journal of pharmacology, 1982-03, Vol.78 (4), p.487-490 |
| issn | 0014-2999 1879-0712 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adrenergic alpha-Agonists - pharmacology Adrenergic alpha-Antagonists - pharmacology Animals Clonidine Dogs Guinea Pigs Human vas deferens Humans In Vitro Techniques Male Muscle, Smooth - metabolism Norepinephrine - metabolism Phentolamine Phentolamine - pharmacology Presynaptic α-receptors Rabbits Rats Rats, Inbred Strains Species Specificity Swine Vas Deferens - metabolism Yohimbine |
| title | Effects of α-adrenoceptor agents on norepinephrine release from vas deferens of several species including man |
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