Methotrexate analogs. 11. Unambiguous chemical synthesis and in vitro biological evaluation of .alpha.- and .gamma.-monoesters as potential prodrugs
Gespeichert in:
| Veröffentlicht in: | Journal of medicinal chemistry 1978-04, Vol.21 (4), p.380-386 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 386 |
|---|---|
| container_issue | 4 |
| container_start_page | 380 |
| container_title | Journal of medicinal chemistry |
| container_volume | 21 |
| creator | Rosowsky, Andre Beardsley, G. Peter Ensminger, William D Lazarus, Herbert Yu, Cheng-Sein |
| description | |
| doi_str_mv | 10.1021/jm00202a013 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_74029388</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>74029388</sourcerecordid><originalsourceid>FETCH-LOGICAL-a268t-a688a2765ddb62cc74f8b3ca0a9222dcc08b4881ffdec0595b2588d07a0853ce3</originalsourceid><addsrcrecordid>eNptkU9v1DAQxS3Ev6Vw4srBJzighLEdJ94jWkFBWgSILVdr4ji7XpJ4aztV-z34wJimqjhwsuz3mzfjeYS8ZFAy4OzdcQTgwBGYeEBWTHIoKgXVQ7LK77zgNRdPybMYjwAgGBdPyGNZS8XUivz-YtPBp2CvMVmKEw5-H0vKWEkvJhxbt5_9HKk52NEZHGi8mdLBRhcz21E30SuXgqet87nwlrBXOMyYnJ-o72mJw-mAZXGLl3scx3wZ_eRtTDZkl0hPPtkpuVx6Cr4L8z4-J496HKJ9cXeekYuPH3abT8X26_nnzfttgbxWqcBaKeRNLbuurbkxTdWrVhgEXHPOO2NAtZVSrO87a0CuZculUh00CEoKY8UZeb345saXc55Ijy4aOww42fxr3VTA10KpDL5dQBN8jMH2-hTciOFGM9B_I9D_RJDpV3e2czva7p5ddp7lYpFdXsH1vYrhl64b0Ui9-_ZDq93m51aef9c8828WHk3URz-HHFL8b-M_jdae5A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>74029388</pqid></control><display><type>article</type><title>Methotrexate analogs. 11. Unambiguous chemical synthesis and in vitro biological evaluation of .alpha.- and .gamma.-monoesters as potential prodrugs</title><source>ACS Publications</source><source>MEDLINE</source><creator>Rosowsky, Andre ; Beardsley, G. Peter ; Ensminger, William D ; Lazarus, Herbert ; Yu, Cheng-Sein</creator><creatorcontrib>Rosowsky, Andre ; Beardsley, G. Peter ; Ensminger, William D ; Lazarus, Herbert ; Yu, Cheng-Sein</creatorcontrib><identifier>ISSN: 0022-2623</identifier><identifier>EISSN: 1520-4804</identifier><identifier>DOI: 10.1021/jm00202a013</identifier><identifier>PMID: 565818</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Animals ; Biotransformation ; Cell Division - drug effects ; Cells, Cultured ; Esterases - blood ; Esterification ; Folic Acid Antagonists ; Humans ; In Vitro Techniques ; Isomerism ; Leukemia, Experimental - pathology ; Methotrexate - analogs & derivatives ; Methotrexate - blood ; Methotrexate - chemical synthesis ; Methotrexate - pharmacology ; Species Specificity</subject><ispartof>Journal of medicinal chemistry, 1978-04, Vol.21 (4), p.380-386</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a268t-a688a2765ddb62cc74f8b3ca0a9222dcc08b4881ffdec0595b2588d07a0853ce3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jm00202a013$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jm00202a013$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/565818$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosowsky, Andre</creatorcontrib><creatorcontrib>Beardsley, G. Peter</creatorcontrib><creatorcontrib>Ensminger, William D</creatorcontrib><creatorcontrib>Lazarus, Herbert</creatorcontrib><creatorcontrib>Yu, Cheng-Sein</creatorcontrib><title>Methotrexate analogs. 11. Unambiguous chemical synthesis and in vitro biological evaluation of .alpha.- and .gamma.-monoesters as potential prodrugs</title><title>Journal of medicinal chemistry</title><addtitle>J. Med. Chem</addtitle><subject>Animals</subject><subject>Biotransformation</subject><subject>Cell Division - drug effects</subject><subject>Cells, Cultured</subject><subject>Esterases - blood</subject><subject>Esterification</subject><subject>Folic Acid Antagonists</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Isomerism</subject><subject>Leukemia, Experimental - pathology</subject><subject>Methotrexate - analogs & derivatives</subject><subject>Methotrexate - blood</subject><subject>Methotrexate - chemical synthesis</subject><subject>Methotrexate - pharmacology</subject><subject>Species Specificity</subject><issn>0022-2623</issn><issn>1520-4804</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkU9v1DAQxS3Ev6Vw4srBJzighLEdJ94jWkFBWgSILVdr4ji7XpJ4aztV-z34wJimqjhwsuz3mzfjeYS8ZFAy4OzdcQTgwBGYeEBWTHIoKgXVQ7LK77zgNRdPybMYjwAgGBdPyGNZS8XUivz-YtPBp2CvMVmKEw5-H0vKWEkvJhxbt5_9HKk52NEZHGi8mdLBRhcz21E30SuXgqet87nwlrBXOMyYnJ-o72mJw-mAZXGLl3scx3wZ_eRtTDZkl0hPPtkpuVx6Cr4L8z4-J496HKJ9cXeekYuPH3abT8X26_nnzfttgbxWqcBaKeRNLbuurbkxTdWrVhgEXHPOO2NAtZVSrO87a0CuZculUh00CEoKY8UZeb345saXc55Ijy4aOww42fxr3VTA10KpDL5dQBN8jMH2-hTciOFGM9B_I9D_RJDpV3e2czva7p5ddp7lYpFdXsH1vYrhl64b0Ui9-_ZDq93m51aef9c8828WHk3URz-HHFL8b-M_jdae5A</recordid><startdate>197804</startdate><enddate>197804</enddate><creator>Rosowsky, Andre</creator><creator>Beardsley, G. Peter</creator><creator>Ensminger, William D</creator><creator>Lazarus, Herbert</creator><creator>Yu, Cheng-Sein</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197804</creationdate><title>Methotrexate analogs. 11. Unambiguous chemical synthesis and in vitro biological evaluation of .alpha.- and .gamma.-monoesters as potential prodrugs</title><author>Rosowsky, Andre ; Beardsley, G. Peter ; Ensminger, William D ; Lazarus, Herbert ; Yu, Cheng-Sein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a268t-a688a2765ddb62cc74f8b3ca0a9222dcc08b4881ffdec0595b2588d07a0853ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Animals</topic><topic>Biotransformation</topic><topic>Cell Division - drug effects</topic><topic>Cells, Cultured</topic><topic>Esterases - blood</topic><topic>Esterification</topic><topic>Folic Acid Antagonists</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Isomerism</topic><topic>Leukemia, Experimental - pathology</topic><topic>Methotrexate - analogs & derivatives</topic><topic>Methotrexate - blood</topic><topic>Methotrexate - chemical synthesis</topic><topic>Methotrexate - pharmacology</topic><topic>Species Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosowsky, Andre</creatorcontrib><creatorcontrib>Beardsley, G. Peter</creatorcontrib><creatorcontrib>Ensminger, William D</creatorcontrib><creatorcontrib>Lazarus, Herbert</creatorcontrib><creatorcontrib>Yu, Cheng-Sein</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosowsky, Andre</au><au>Beardsley, G. Peter</au><au>Ensminger, William D</au><au>Lazarus, Herbert</au><au>Yu, Cheng-Sein</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Methotrexate analogs. 11. Unambiguous chemical synthesis and in vitro biological evaluation of .alpha.- and .gamma.-monoesters as potential prodrugs</atitle><jtitle>Journal of medicinal chemistry</jtitle><addtitle>J. Med. Chem</addtitle><date>1978-04</date><risdate>1978</risdate><volume>21</volume><issue>4</issue><spage>380</spage><epage>386</epage><pages>380-386</pages><issn>0022-2623</issn><eissn>1520-4804</eissn><cop>United States</cop><pub>American Chemical Society</pub><pmid>565818</pmid><doi>10.1021/jm00202a013</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-2623 |
| ispartof | Journal of medicinal chemistry, 1978-04, Vol.21 (4), p.380-386 |
| issn | 0022-2623 1520-4804 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74029388 |
| source | ACS Publications; MEDLINE |
| subjects | Animals Biotransformation Cell Division - drug effects Cells, Cultured Esterases - blood Esterification Folic Acid Antagonists Humans In Vitro Techniques Isomerism Leukemia, Experimental - pathology Methotrexate - analogs & derivatives Methotrexate - blood Methotrexate - chemical synthesis Methotrexate - pharmacology Species Specificity |
| title | Methotrexate analogs. 11. Unambiguous chemical synthesis and in vitro biological evaluation of .alpha.- and .gamma.-monoesters as potential prodrugs |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T20%3A24%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Methotrexate%20analogs.%2011.%20Unambiguous%20chemical%20synthesis%20and%20in%20vitro%20biological%20evaluation%20of%20.alpha.-%20and%20.gamma.-monoesters%20as%20potential%20prodrugs&rft.jtitle=Journal%20of%20medicinal%20chemistry&rft.au=Rosowsky,%20Andre&rft.date=1978-04&rft.volume=21&rft.issue=4&rft.spage=380&rft.epage=386&rft.pages=380-386&rft.issn=0022-2623&rft.eissn=1520-4804&rft_id=info:doi/10.1021/jm00202a013&rft_dat=%3Cproquest_cross%3E74029388%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=74029388&rft_id=info:pmid/565818&rfr_iscdi=true |