Biphasic effect of somatostatin on oral glucose tolerance in maturity-onset diabetes
Oral glucose tolerance was examined in five maturity-onset diabetics during the infusion of somatostatin or saline. Somatostatin inhibited glucose-stimulated insulin release and reduced plasma glucagon by 50%–65%. The rise in plasma glucose after glucose ingestion was initially (at 30–120 min) reduc...
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| Veröffentlicht in: | Metabolism, clinical and experimental clinical and experimental, 1978-07, Vol.27 (7), p.849-853 |
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| container_issue | 7 |
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| container_title | Metabolism, clinical and experimental |
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| creator | Tamborlane, William V. Sherwin, Robert S. Hendler, Rosa Felig, Philip |
| description | Oral glucose tolerance was examined in five maturity-onset diabetics during the infusion of somatostatin or saline. Somatostatin inhibited glucose-stimulated insulin release and reduced plasma glucagon by 50%–65%. The rise in plasma glucose after glucose ingestion was initially (at 30–120 min) reduced by somatostatin. However, beyond 3 hr, plasma glucose levels were
50–200 mg
100 ml
higher, with somatostatin reaching concentrations at 6 hr that were twofold higher than those observed with saline (
p < 0.005). The degree of late glucose intolerance was inversely related to postglucose plasma insulin concentrations (
p < 0.01). These findings demonstrate a biphasic effect of somatostatin on oral glucose tolerance in maturity-onset diabetes. The exaggerated late hyperglycemia is related to suppression of insulin secretion. The initial blunting of postprandial hyperglycemia may reflect decreased carbohydrate absorption and/or hypoglucagonemia-mediated enhancement of glucose disposal. |
| doi_str_mv | 10.1016/0026-0495(78)90219-6 |
| format | Article |
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50–200 mg
100 ml
higher, with somatostatin reaching concentrations at 6 hr that were twofold higher than those observed with saline (
p < 0.005). The degree of late glucose intolerance was inversely related to postglucose plasma insulin concentrations (
p < 0.01). These findings demonstrate a biphasic effect of somatostatin on oral glucose tolerance in maturity-onset diabetes. The exaggerated late hyperglycemia is related to suppression of insulin secretion. The initial blunting of postprandial hyperglycemia may reflect decreased carbohydrate absorption and/or hypoglucagonemia-mediated enhancement of glucose disposal.</description><identifier>ISSN: 0026-0495</identifier><identifier>EISSN: 1532-8600</identifier><identifier>DOI: 10.1016/0026-0495(78)90219-6</identifier><identifier>PMID: 661568</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Blood Glucose - metabolism ; Diabetes Mellitus - metabolism ; Female ; Glucagon - blood ; Glucose - metabolism ; Glucose Tolerance Test ; Humans ; Insulin - blood ; Male ; Middle Aged ; Somatostatin - pharmacology</subject><ispartof>Metabolism, clinical and experimental, 1978-07, Vol.27 (7), p.849-853</ispartof><rights>1978</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-ccd0b17399cd58b0bfd639447cbeea71c307ad45fcaa3c94c68ab13bc6d94fb53</citedby><cites>FETCH-LOGICAL-c356t-ccd0b17399cd58b0bfd639447cbeea71c307ad45fcaa3c94c68ab13bc6d94fb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0026-0495(78)90219-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/661568$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tamborlane, William V.</creatorcontrib><creatorcontrib>Sherwin, Robert S.</creatorcontrib><creatorcontrib>Hendler, Rosa</creatorcontrib><creatorcontrib>Felig, Philip</creatorcontrib><title>Biphasic effect of somatostatin on oral glucose tolerance in maturity-onset diabetes</title><title>Metabolism, clinical and experimental</title><addtitle>Metabolism</addtitle><description>Oral glucose tolerance was examined in five maturity-onset diabetics during the infusion of somatostatin or saline. Somatostatin inhibited glucose-stimulated insulin release and reduced plasma glucagon by 50%–65%. The rise in plasma glucose after glucose ingestion was initially (at 30–120 min) reduced by somatostatin. However, beyond 3 hr, plasma glucose levels were
50–200 mg
100 ml
higher, with somatostatin reaching concentrations at 6 hr that were twofold higher than those observed with saline (
p < 0.005). The degree of late glucose intolerance was inversely related to postglucose plasma insulin concentrations (
p < 0.01). These findings demonstrate a biphasic effect of somatostatin on oral glucose tolerance in maturity-onset diabetes. The exaggerated late hyperglycemia is related to suppression of insulin secretion. The initial blunting of postprandial hyperglycemia may reflect decreased carbohydrate absorption and/or hypoglucagonemia-mediated enhancement of glucose disposal.</description><subject>Adult</subject><subject>Blood Glucose - metabolism</subject><subject>Diabetes Mellitus - metabolism</subject><subject>Female</subject><subject>Glucagon - blood</subject><subject>Glucose - metabolism</subject><subject>Glucose Tolerance Test</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Somatostatin - pharmacology</subject><issn>0026-0495</issn><issn>1532-8600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoP4Vav_oIc9iR5Wk2422b0IWvyCgpd6DslkViPbpiZZof_e1IpHYWAO7zMvzEPIhNErRpm4pnQqSsrb-kI2ly2dsrYUe2TE6mpaNoLSfTL6Q47JSYwflFIpG3FEDoVgtWhGZHHn1u86Oiiw6xBS4bsi-qVOPiad3KrweYLui7d-AB-xSL7HoFeARQ4zNwSXNqVfRUyFddpgwnhKDjrdRzz73WPy-nC_mD2V85fH59ntvISqFqkEsNQwWbUt2Lox1HRWVC3nEgyilgwqKrXldQdaV9ByEI02rDIgbMs7U1djcr7rXQf_OWBMaukiYN_rFfohKsnpVPKaZ5DvQAg-xoCdWge31GGjGFVbl2orSm1FKdmoH5dK5LPJb_9glmj_jnbycnyzizH_-OUwqAgOsxrrQlaprHf_938DgPOE_Q</recordid><startdate>197807</startdate><enddate>197807</enddate><creator>Tamborlane, William V.</creator><creator>Sherwin, Robert S.</creator><creator>Hendler, Rosa</creator><creator>Felig, Philip</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197807</creationdate><title>Biphasic effect of somatostatin on oral glucose tolerance in maturity-onset diabetes</title><author>Tamborlane, William V. ; Sherwin, Robert S. ; Hendler, Rosa ; Felig, Philip</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-ccd0b17399cd58b0bfd639447cbeea71c307ad45fcaa3c94c68ab13bc6d94fb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Adult</topic><topic>Blood Glucose - metabolism</topic><topic>Diabetes Mellitus - metabolism</topic><topic>Female</topic><topic>Glucagon - blood</topic><topic>Glucose - metabolism</topic><topic>Glucose Tolerance Test</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Somatostatin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tamborlane, William V.</creatorcontrib><creatorcontrib>Sherwin, Robert S.</creatorcontrib><creatorcontrib>Hendler, Rosa</creatorcontrib><creatorcontrib>Felig, Philip</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolism, clinical and experimental</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tamborlane, William V.</au><au>Sherwin, Robert S.</au><au>Hendler, Rosa</au><au>Felig, Philip</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biphasic effect of somatostatin on oral glucose tolerance in maturity-onset diabetes</atitle><jtitle>Metabolism, clinical and experimental</jtitle><addtitle>Metabolism</addtitle><date>1978-07</date><risdate>1978</risdate><volume>27</volume><issue>7</issue><spage>849</spage><epage>853</epage><pages>849-853</pages><issn>0026-0495</issn><eissn>1532-8600</eissn><abstract>Oral glucose tolerance was examined in five maturity-onset diabetics during the infusion of somatostatin or saline. Somatostatin inhibited glucose-stimulated insulin release and reduced plasma glucagon by 50%–65%. The rise in plasma glucose after glucose ingestion was initially (at 30–120 min) reduced by somatostatin. However, beyond 3 hr, plasma glucose levels were
50–200 mg
100 ml
higher, with somatostatin reaching concentrations at 6 hr that were twofold higher than those observed with saline (
p < 0.005). The degree of late glucose intolerance was inversely related to postglucose plasma insulin concentrations (
p < 0.01). These findings demonstrate a biphasic effect of somatostatin on oral glucose tolerance in maturity-onset diabetes. The exaggerated late hyperglycemia is related to suppression of insulin secretion. The initial blunting of postprandial hyperglycemia may reflect decreased carbohydrate absorption and/or hypoglucagonemia-mediated enhancement of glucose disposal.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>661568</pmid><doi>10.1016/0026-0495(78)90219-6</doi><tpages>5</tpages></addata></record> |
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| ispartof | Metabolism, clinical and experimental, 1978-07, Vol.27 (7), p.849-853 |
| issn | 0026-0495 1532-8600 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Blood Glucose - metabolism Diabetes Mellitus - metabolism Female Glucagon - blood Glucose - metabolism Glucose Tolerance Test Humans Insulin - blood Male Middle Aged Somatostatin - pharmacology |
| title | Biphasic effect of somatostatin on oral glucose tolerance in maturity-onset diabetes |
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