Blockade of neuronal tryptamine receptors by metoclopramide

Metoclopramide (0.13, 0.51, 2.0 and 8.1 × 10 −6 M) caused parallel, rightward, shifts in the dose response curves to 5-HT on the isolated rabbit heart. A sinificant straight line relationship was found between log (5-HT dr−1) and log [metoclopramide] (molar) with a slope of 1.08 ± 0.13 and giving a...

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Veröffentlicht in:	European journal of pharmacology 1978-05, Vol.49 (1), p.109-112
Hauptverfasser:	Fozard, John R., Mobarok Ali, Abu T.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT Animals Cardiac sympathetic nerves Dimethylphenylpiperazinium Iodide - pharmacology Female Heart - innervation Heart Rate - drug effects In Vitro Techniques Male Metoclopramide Metoclopramide - pharmacology Myocardial Contraction - drug effects Neuronal tryptamine receptors Neurons - drug effects Rabbits Receptors, Serotonin - drug effects Serotonin - pharmacology Sympathetic Nervous System - drug effects
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