Blockade of neuronal tryptamine receptors by metoclopramide
Metoclopramide (0.13, 0.51, 2.0 and 8.1 × 10 −6 M) caused parallel, rightward, shifts in the dose response curves to 5-HT on the isolated rabbit heart. A sinificant straight line relationship was found between log (5-HT dr−1) and log [metoclopramide] (molar) with a slope of 1.08 ± 0.13 and giving a...
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| Veröffentlicht in: | European journal of pharmacology 1978-05, Vol.49 (1), p.109-112 |
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| container_title | European journal of pharmacology |
| container_volume | 49 |
| creator | Fozard, John R. Mobarok Ali, Abu T.M. |
| description | Metoclopramide (0.13, 0.51, 2.0 and 8.1 × 10
−6 M) caused parallel, rightward, shifts in the dose response curves to 5-HT on the isolated rabbit heart. A sinificant straight line relationship was found between log (5-HT dr−1) and log [metoclopramide] (molar) with a slope of 1.08 ± 0.13 and giving a pA
2 value of 7.20. Metoclopramide did not significantly alter responses to noradrenaline and was 575 times less effective as an inhibitor of DMPP than 5-HT. The results indicate that metoclopramide is a potent, surmountable and selective antagonist of tryptamine receptors on rabbit cardiac sympathetic nerves. |
| doi_str_mv | 10.1016/0014-2999(78)90228-5 |
| format | Article |
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2 value of 7.20. Metoclopramide did not significantly alter responses to noradrenaline and was 575 times less effective as an inhibitor of DMPP than 5-HT. The results indicate that metoclopramide is a potent, surmountable and selective antagonist of tryptamine receptors on rabbit cardiac sympathetic nerves.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(78)90228-5</identifier><identifier>PMID: 658121</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>5-HT ; Animals ; Cardiac sympathetic nerves ; Dimethylphenylpiperazinium Iodide - pharmacology ; Female ; Heart - innervation ; Heart Rate - drug effects ; In Vitro Techniques ; Male ; Metoclopramide ; Metoclopramide - pharmacology ; Myocardial Contraction - drug effects ; Neuronal tryptamine receptors ; Neurons - drug effects ; Rabbits ; Receptors, Serotonin - drug effects ; Serotonin - pharmacology ; Sympathetic Nervous System - drug effects</subject><ispartof>European journal of pharmacology, 1978-05, Vol.49 (1), p.109-112</ispartof><rights>1978</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-d41f5cd645aff490e9aa731c2ae3d3d88cb5fb4101a354066bddd47ab9719f543</citedby><cites>FETCH-LOGICAL-c356t-d41f5cd645aff490e9aa731c2ae3d3d88cb5fb4101a354066bddd47ab9719f543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0014299978902285$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/658121$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fozard, John R.</creatorcontrib><creatorcontrib>Mobarok Ali, Abu T.M.</creatorcontrib><title>Blockade of neuronal tryptamine receptors by metoclopramide</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>Metoclopramide (0.13, 0.51, 2.0 and 8.1 × 10
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2 value of 7.20. Metoclopramide did not significantly alter responses to noradrenaline and was 575 times less effective as an inhibitor of DMPP than 5-HT. The results indicate that metoclopramide is a potent, surmountable and selective antagonist of tryptamine receptors on rabbit cardiac sympathetic nerves.</description><subject>5-HT</subject><subject>Animals</subject><subject>Cardiac sympathetic nerves</subject><subject>Dimethylphenylpiperazinium Iodide - pharmacology</subject><subject>Female</subject><subject>Heart - innervation</subject><subject>Heart Rate - drug effects</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Metoclopramide</subject><subject>Metoclopramide - pharmacology</subject><subject>Myocardial Contraction - drug effects</subject><subject>Neuronal tryptamine receptors</subject><subject>Neurons - drug effects</subject><subject>Rabbits</subject><subject>Receptors, Serotonin - drug effects</subject><subject>Serotonin - pharmacology</subject><subject>Sympathetic Nervous System - drug effects</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxDAYhYN4G0ffYBZdiS6qSZo0DcKADt5gwI2uQ5r8gWrb1KQV5u3t2GGWrs7iXOB8CC0IviGY5LcYE5ZSKeWVKK4lprRI-QGakULIFAtCD9FsHzlFZzF-Yoy5pPwEHee8IJTM0N1D7c2XtpB4l7QwBN_qOunDput1U7WQBDDQ9T7EpNwkDfTe1L4Lo2fhHB05XUe42OkcfTw9vq9e0vXb8-vqfp2ajOd9ahlx3Nicce0ckxik1iIjhmrIbGaLwpTclWy8pDPOcJ6X1lomdCkFkY6zbI4up90u-O8BYq-aKhqoa92CH6ISDFNBmRiDbAqa4GMM4FQXqkaHjSJYbZGpLQ-15aFEof6QKT7WFrv9oWzA7ksTo9FeTjaMH38qCCqaCloDthrh9Mr66v_9X2TAeyI</recordid><startdate>19780501</startdate><enddate>19780501</enddate><creator>Fozard, John R.</creator><creator>Mobarok Ali, Abu T.M.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19780501</creationdate><title>Blockade of neuronal tryptamine receptors by metoclopramide</title><author>Fozard, John R. ; Mobarok Ali, Abu T.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-d41f5cd645aff490e9aa731c2ae3d3d88cb5fb4101a354066bddd47ab9719f543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>5-HT</topic><topic>Animals</topic><topic>Cardiac sympathetic nerves</topic><topic>Dimethylphenylpiperazinium Iodide - pharmacology</topic><topic>Female</topic><topic>Heart - innervation</topic><topic>Heart Rate - drug effects</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Metoclopramide</topic><topic>Metoclopramide - pharmacology</topic><topic>Myocardial Contraction - drug effects</topic><topic>Neuronal tryptamine receptors</topic><topic>Neurons - drug effects</topic><topic>Rabbits</topic><topic>Receptors, Serotonin - drug effects</topic><topic>Serotonin - pharmacology</topic><topic>Sympathetic Nervous System - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fozard, John R.</creatorcontrib><creatorcontrib>Mobarok Ali, Abu T.M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fozard, John R.</au><au>Mobarok Ali, Abu T.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blockade of neuronal tryptamine receptors by metoclopramide</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1978-05-01</date><risdate>1978</risdate><volume>49</volume><issue>1</issue><spage>109</spage><epage>112</epage><pages>109-112</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>Metoclopramide (0.13, 0.51, 2.0 and 8.1 × 10
−6 M) caused parallel, rightward, shifts in the dose response curves to 5-HT on the isolated rabbit heart. A sinificant straight line relationship was found between log (5-HT dr−1) and log [metoclopramide] (molar) with a slope of 1.08 ± 0.13 and giving a pA
2 value of 7.20. Metoclopramide did not significantly alter responses to noradrenaline and was 575 times less effective as an inhibitor of DMPP than 5-HT. The results indicate that metoclopramide is a potent, surmountable and selective antagonist of tryptamine receptors on rabbit cardiac sympathetic nerves.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>658121</pmid><doi>10.1016/0014-2999(78)90228-5</doi><tpages>4</tpages></addata></record> |
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| ispartof | European journal of pharmacology, 1978-05, Vol.49 (1), p.109-112 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 5-HT Animals Cardiac sympathetic nerves Dimethylphenylpiperazinium Iodide - pharmacology Female Heart - innervation Heart Rate - drug effects In Vitro Techniques Male Metoclopramide Metoclopramide - pharmacology Myocardial Contraction - drug effects Neuronal tryptamine receptors Neurons - drug effects Rabbits Receptors, Serotonin - drug effects Serotonin - pharmacology Sympathetic Nervous System - drug effects |
| title | Blockade of neuronal tryptamine receptors by metoclopramide |
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