The effectiveness of prophylactic brain irradiation in small cell carcinoma of the lung. A Southwest Oncology Group Study
Brain involvement in small cell carcinoma of the lung is a common phenomenon occurring in from 29 to 45% of patients. Because of this, it was suggested that prophylactic brain irradiation be made a part of treatment plans for small cell carcinoma. In December 1974, the Southwest Oncology Group (SWOG...
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| Veröffentlicht in: | Cancer 1978-06, Vol.41 (6), p.2149-2153 |
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| container_issue | 6 |
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| container_title | Cancer |
| container_volume | 41 |
| creator | Moore, Terence N. Livingston, Robert Heilbrun, Lance Eltringham, James Skinner, Odis White, Joel Tesh, Donald |
| description | Brain involvement in small cell carcinoma of the lung is a common phenomenon occurring in from 29 to 45% of patients. Because of this, it was suggested that prophylactic brain irradiation be made a part of treatment plans for small cell carcinoma. In December 1974, the Southwest Oncology Group (SWOG) began treating patients with combination chemotherapy and irradiation of both the primary lesion and whole brain. In two years, there were 390 patients entered into the study. In patients with extensive disease only 6 of 152 prophylactically irradiated patients developed CNS signs or symptoms of CNS recurrence. In limited disease, 6 of 88 prophylactically treated patients had CNS recurrence and in only 4 was this the site of initial failure. We feel prophylactic brain irradiation in small cell carcinoma of the lung is of benefit. |
| doi_str_mv | 10.1002/1097-0142(197806)41:6<2149::AID-CNCR2820410611>3.0.CO;2-P |
| format | Article |
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A Southwest Oncology Group Study</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Moore, Terence N. ; Livingston, Robert ; Heilbrun, Lance ; Eltringham, James ; Skinner, Odis ; White, Joel ; Tesh, Donald</creator><creatorcontrib>Moore, Terence N. ; Livingston, Robert ; Heilbrun, Lance ; Eltringham, James ; Skinner, Odis ; White, Joel ; Tesh, Donald</creatorcontrib><description>Brain involvement in small cell carcinoma of the lung is a common phenomenon occurring in from 29 to 45% of patients. Because of this, it was suggested that prophylactic brain irradiation be made a part of treatment plans for small cell carcinoma. In December 1974, the Southwest Oncology Group (SWOG) began treating patients with combination chemotherapy and irradiation of both the primary lesion and whole brain. In two years, there were 390 patients entered into the study. In patients with extensive disease only 6 of 152 prophylactically irradiated patients developed CNS signs or symptoms of CNS recurrence. In limited disease, 6 of 88 prophylactically treated patients had CNS recurrence and in only 4 was this the site of initial failure. We feel prophylactic brain irradiation in small cell carcinoma of the lung is of benefit.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(197806)41:6<2149::AID-CNCR2820410611>3.0.CO;2-P</identifier><identifier>PMID: 207406</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Brain Neoplasms - prevention & control ; Brain Neoplasms - radiotherapy ; Carcinoma, Small Cell - radiotherapy ; Female ; Humans ; Lung Neoplasms - radiotherapy ; Male ; Neoplasm Metastasis - prevention & control ; Neoplasm Metastasis - radiotherapy ; Radiotherapy Dosage ; Recurrence ; Remission, Spontaneous ; Time Factors</subject><ispartof>Cancer, 1978-06, Vol.41 (6), p.2149-2153</ispartof><rights>Copyright © 1978 American Cancer Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4621-9d0e788979fe4833108af9e6db7e14891b8228b69d6950dc89e8841aef396a543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/207406$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moore, Terence N.</creatorcontrib><creatorcontrib>Livingston, Robert</creatorcontrib><creatorcontrib>Heilbrun, Lance</creatorcontrib><creatorcontrib>Eltringham, James</creatorcontrib><creatorcontrib>Skinner, Odis</creatorcontrib><creatorcontrib>White, Joel</creatorcontrib><creatorcontrib>Tesh, Donald</creatorcontrib><title>The effectiveness of prophylactic brain irradiation in small cell carcinoma of the lung. A Southwest Oncology Group Study</title><title>Cancer</title><addtitle>Cancer</addtitle><description>Brain involvement in small cell carcinoma of the lung is a common phenomenon occurring in from 29 to 45% of patients. Because of this, it was suggested that prophylactic brain irradiation be made a part of treatment plans for small cell carcinoma. In December 1974, the Southwest Oncology Group (SWOG) began treating patients with combination chemotherapy and irradiation of both the primary lesion and whole brain. In two years, there were 390 patients entered into the study. In patients with extensive disease only 6 of 152 prophylactically irradiated patients developed CNS signs or symptoms of CNS recurrence. In limited disease, 6 of 88 prophylactically treated patients had CNS recurrence and in only 4 was this the site of initial failure. We feel prophylactic brain irradiation in small cell carcinoma of the lung is of benefit.</description><subject>Brain Neoplasms - prevention & control</subject><subject>Brain Neoplasms - radiotherapy</subject><subject>Carcinoma, Small Cell - radiotherapy</subject><subject>Female</subject><subject>Humans</subject><subject>Lung Neoplasms - radiotherapy</subject><subject>Male</subject><subject>Neoplasm Metastasis - prevention & control</subject><subject>Neoplasm Metastasis - radiotherapy</subject><subject>Radiotherapy Dosage</subject><subject>Recurrence</subject><subject>Remission, Spontaneous</subject><subject>Time Factors</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVUU1v1DAQtRBfS-EfcPAJwSHL2PE69oKQVgFKpYqtaJHgNHISpxuUxIudUOXf4yhVJTggcbE9fjPvzcwjZMdgzQD4awY6S4AJ_pLpTIF8JdhWvuVM6O12d_Y-yT_nX7jiIBhIxt6la1jn-zc8ubhHVne198kKAFSyEem3x-RJCD9imPFN-og85JAJkCsyXR0stXVty6H5ZXsbAnU1PXp3PEytiZ8lLbxpetp4b6rGDI2L756GzrQtLe18GF82vevMXDlEunbsr9d0Ry_dOBxubBjovi9d664neurdeKSXw1hNT8mD2rTBPru9T8jXjx-u8k_J-f70LN-dJ6WQnCW6ApsppTNdW6HSlIEytbayKjLLhNKsUJyrQupK6g1UpdJWKcGMrVMtTRz9hLxYeONQP8fYDXZNmBs3vXVjwLgHLqNSTPy-JJbeheBtjUffdMZPyABnV3DeLM6bxcUVFAwlzq4gRlfwT1cwRcB8jxwvIvfz2ybGorPVHfNiQ4SrBb5pWjv9j-4_Zf9C0t_un6oq</recordid><startdate>197806</startdate><enddate>197806</enddate><creator>Moore, Terence N.</creator><creator>Livingston, Robert</creator><creator>Heilbrun, Lance</creator><creator>Eltringham, James</creator><creator>Skinner, Odis</creator><creator>White, Joel</creator><creator>Tesh, Donald</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197806</creationdate><title>The effectiveness of prophylactic brain irradiation in small cell carcinoma of the lung. A Southwest Oncology Group Study</title><author>Moore, Terence N. ; Livingston, Robert ; Heilbrun, Lance ; Eltringham, James ; Skinner, Odis ; White, Joel ; Tesh, Donald</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4621-9d0e788979fe4833108af9e6db7e14891b8228b69d6950dc89e8841aef396a543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Brain Neoplasms - prevention & control</topic><topic>Brain Neoplasms - radiotherapy</topic><topic>Carcinoma, Small Cell - radiotherapy</topic><topic>Female</topic><topic>Humans</topic><topic>Lung Neoplasms - radiotherapy</topic><topic>Male</topic><topic>Neoplasm Metastasis - prevention & control</topic><topic>Neoplasm Metastasis - radiotherapy</topic><topic>Radiotherapy Dosage</topic><topic>Recurrence</topic><topic>Remission, Spontaneous</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moore, Terence N.</creatorcontrib><creatorcontrib>Livingston, Robert</creatorcontrib><creatorcontrib>Heilbrun, Lance</creatorcontrib><creatorcontrib>Eltringham, James</creatorcontrib><creatorcontrib>Skinner, Odis</creatorcontrib><creatorcontrib>White, Joel</creatorcontrib><creatorcontrib>Tesh, Donald</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moore, Terence N.</au><au>Livingston, Robert</au><au>Heilbrun, Lance</au><au>Eltringham, James</au><au>Skinner, Odis</au><au>White, Joel</au><au>Tesh, Donald</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effectiveness of prophylactic brain irradiation in small cell carcinoma of the lung. A Southwest Oncology Group Study</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1978-06</date><risdate>1978</risdate><volume>41</volume><issue>6</issue><spage>2149</spage><epage>2153</epage><pages>2149-2153</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>Brain involvement in small cell carcinoma of the lung is a common phenomenon occurring in from 29 to 45% of patients. Because of this, it was suggested that prophylactic brain irradiation be made a part of treatment plans for small cell carcinoma. In December 1974, the Southwest Oncology Group (SWOG) began treating patients with combination chemotherapy and irradiation of both the primary lesion and whole brain. In two years, there were 390 patients entered into the study. In patients with extensive disease only 6 of 152 prophylactically irradiated patients developed CNS signs or symptoms of CNS recurrence. In limited disease, 6 of 88 prophylactically treated patients had CNS recurrence and in only 4 was this the site of initial failure. We feel prophylactic brain irradiation in small cell carcinoma of the lung is of benefit.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>207406</pmid><doi>10.1002/1097-0142(197806)41:6<2149::AID-CNCR2820410611>3.0.CO;2-P</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer, 1978-06, Vol.41 (6), p.2149-2153 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Brain Neoplasms - prevention & control Brain Neoplasms - radiotherapy Carcinoma, Small Cell - radiotherapy Female Humans Lung Neoplasms - radiotherapy Male Neoplasm Metastasis - prevention & control Neoplasm Metastasis - radiotherapy Radiotherapy Dosage Recurrence Remission, Spontaneous Time Factors |
| title | The effectiveness of prophylactic brain irradiation in small cell carcinoma of the lung. A Southwest Oncology Group Study |
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