Inhibitory effects of various 5-halogenated derivatives of 1-.beta.-D-arabinofuranosyluracil 5'-triphosphate on DNA polymerases from murine cells and oncornavirus: substituent effects on inhibitory action

The effects of four 5-halogenated derivatives of 1- beta -D-arabinofuranosyluracil 5'-triphosphate (aUTP) on the activity of DNA polymerases from mouse cells and oncornavirus were examined. The newly synthesized and tested compounds in this study were 1- beta -D-arabinofuranosyl-5-fluorouracil...

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Veröffentlicht in:	Biochemistry (Easton) 1982-03, Vol.21 (5), p.1019-1024
Hauptverfasser:	Ono, Katsuhiko, Ogasawara, Masako, Ohashi, Atsuko, Matsukage, Akio, Takahashi, Taijo, Nakayama, Chikao, Saneyoshi, Mineo
Format:	Artikel
Sprache:	eng
Schlagworte:	1- beta -D-arabinofuranosyluracil 5'-triphosphate Animals Arabinofuranosyluracil - pharmacology Arabinonucleotides - pharmacology cell lines DNA polymerase Kinetics Mice Nucleic Acid Synthesis Inhibitors oncornavirus Reverse Transcriptase Inhibitors Structure-Activity Relationship Uridine - analogs & derivatives Uridine Triphosphate - analogs & derivatives
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