Sequence of RNA segment 7 of the influenza B virus genome: Partial amino acid homology between the membrane proteins (M 1) of Influenza A and B viruses and conservation of a second open reading frame
The complete nucleotide sequence of a cloned full-length DNA copy of genome RNA segment 7 of influenza B/Lee/40 virus has been determined. The messenger RNA (∼ 1175 viral nucleotides) for the nonglycosylated membrane protein of the virus (M 1) is capable of coding for a protein of 248 amino acids, o...
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Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 1982-01, Vol.116 (2), p.581-588 |
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description | The complete nucleotide sequence of a cloned full-length DNA copy of genome RNA segment 7 of influenza B/Lee/40 virus has been determined. The messenger RNA (∼ 1175 viral nucleotides) for the nonglycosylated membrane protein of the virus (M
1) is capable of coding for a protein of 248 amino acids, of which 63 are conserved between influenza A and B viruses. An internal hydrophobic domain, which includes three cysteine residues in the same positions, is also conserved between the M
1 proteins of the two viruses and may be of functional significance. A second coding region overlaps that of the influenza B M
1 protein by 86 amino acids. This region could code for a maximum of 195 amino acids in the +2 reading frame, depending on whether or not the mRNA is spliced and the location of the initiating methionine residue. This region is likely to code for a protein analogous to the influenza A virus M
2 protein. No obvious homology has been detected in the deduced amino sequences of the M
2 proteins of the two viruses. The size of the M
1 coding regions is conserved between influenza A and B viruses, however the B virus segment 7 is larger, with the difference largely due to a longer M
2 coding region. |
doi_str_mv | 10.1016/0042-6822(82)90150-7 |
format | Article |
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1) is capable of coding for a protein of 248 amino acids, of which 63 are conserved between influenza A and B viruses. An internal hydrophobic domain, which includes three cysteine residues in the same positions, is also conserved between the M
1 proteins of the two viruses and may be of functional significance. A second coding region overlaps that of the influenza B M
1 protein by 86 amino acids. This region could code for a maximum of 195 amino acids in the +2 reading frame, depending on whether or not the mRNA is spliced and the location of the initiating methionine residue. This region is likely to code for a protein analogous to the influenza A virus M
2 protein. No obvious homology has been detected in the deduced amino sequences of the M
2 proteins of the two viruses. The size of the M
1 coding regions is conserved between influenza A and B viruses, however the B virus segment 7 is larger, with the difference largely due to a longer M
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1) is capable of coding for a protein of 248 amino acids, of which 63 are conserved between influenza A and B viruses. An internal hydrophobic domain, which includes three cysteine residues in the same positions, is also conserved between the M
1 proteins of the two viruses and may be of functional significance. A second coding region overlaps that of the influenza B M
1 protein by 86 amino acids. This region could code for a maximum of 195 amino acids in the +2 reading frame, depending on whether or not the mRNA is spliced and the location of the initiating methionine residue. This region is likely to code for a protein analogous to the influenza A virus M
2 protein. No obvious homology has been detected in the deduced amino sequences of the M
2 proteins of the two viruses. The size of the M
1 coding regions is conserved between influenza A and B viruses, however the B virus segment 7 is larger, with the difference largely due to a longer M
2 coding region.</description><subject>Amino Acid Sequence</subject><subject>Base Sequence</subject><subject>DNA Restriction Enzymes</subject><subject>Genes, Viral</subject><subject>Genetic Code</subject><subject>Humans</subject><subject>influenza A virus</subject><subject>Influenza A virus - genetics</subject><subject>influenza B virus</subject><subject>Models, Genetic</subject><subject>Orthomyxoviridae - genetics</subject><subject>Viral Matrix Proteins</subject><subject>Viral Proteins - analysis</subject><subject>Viral Proteins - genetics</subject><issn>0042-6822</issn><issn>1096-0341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUtuOFCEQJUazjqt_oAlPZvehFWi6oX3YZNx42WS9xMszoaF6FtPACD1j1h_0t6RnxnlUn0hVnTqHqjoIPabkGSW0fU4IZ1UrGTuT7LwjtCGVuIMWlHRtRWpO76LFEXIfPcj5GymxEOQEnbRMSMG6Bfr1Gb5vIBjAccCf3i9xhpWHMGExJ6YbwC4MY0H81Pgl3rq0yXgFIXp4gT_qNDk9Yu1diFgbZ_FN9HGMq1vcw_QDIOwYPPg-6QB4neIELmR89g7T81ng6ki-xDrYPxKQd5GJIUPa6snFMKN1-V3JWRzXhTqBti6s8JC0h4fo3qDHDI8O7yn6-vrVl8u31fWHN1eXy-vK1DWfqloYwVkNQhrGrORN19W9GezQcWtaTVtJBJESWsLapmmo7AbWy75mXOvesL4-RU_3vGWWsrg8Ke-ygXEs88VNVoITKttO_BNIG87LCeT_ACklzczI90CTYs4JBrVOzut0qyhRsyPUfG41n1tJpnaOUHPbkwP_pvdgj00HC5T6xb4OZW1bB0ll42ZHWJfATMpG93eB34YwxXo</recordid><startdate>19820101</startdate><enddate>19820101</enddate><creator>Briedis, Dalius J.</creator><creator>Lamb, Robert A.</creator><creator>Choppin, Purnell W.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19820101</creationdate><title>Sequence of RNA segment 7 of the influenza B virus genome: Partial amino acid homology between the membrane proteins (M 1) of Influenza A and B viruses and conservation of a second open reading frame</title><author>Briedis, Dalius J. ; Lamb, Robert A. ; Choppin, Purnell W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c334t-37c7423e78c22d845993bcfdf94dc6a16807088e6026555189f2b8b324aabc2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Amino Acid Sequence</topic><topic>Base Sequence</topic><topic>DNA Restriction Enzymes</topic><topic>Genes, Viral</topic><topic>Genetic Code</topic><topic>Humans</topic><topic>influenza A virus</topic><topic>Influenza A virus - genetics</topic><topic>influenza B virus</topic><topic>Models, Genetic</topic><topic>Orthomyxoviridae - genetics</topic><topic>Viral Matrix Proteins</topic><topic>Viral Proteins - analysis</topic><topic>Viral Proteins - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Briedis, Dalius J.</creatorcontrib><creatorcontrib>Lamb, Robert A.</creatorcontrib><creatorcontrib>Choppin, Purnell W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Virology (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Briedis, Dalius J.</au><au>Lamb, Robert A.</au><au>Choppin, Purnell W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sequence of RNA segment 7 of the influenza B virus genome: Partial amino acid homology between the membrane proteins (M 1) of Influenza A and B viruses and conservation of a second open reading frame</atitle><jtitle>Virology (New York, N.Y.)</jtitle><addtitle>Virology</addtitle><date>1982-01-01</date><risdate>1982</risdate><volume>116</volume><issue>2</issue><spage>581</spage><epage>588</epage><pages>581-588</pages><issn>0042-6822</issn><eissn>1096-0341</eissn><abstract>The complete nucleotide sequence of a cloned full-length DNA copy of genome RNA segment 7 of influenza B/Lee/40 virus has been determined. The messenger RNA (∼ 1175 viral nucleotides) for the nonglycosylated membrane protein of the virus (M
1) is capable of coding for a protein of 248 amino acids, of which 63 are conserved between influenza A and B viruses. An internal hydrophobic domain, which includes three cysteine residues in the same positions, is also conserved between the M
1 proteins of the two viruses and may be of functional significance. A second coding region overlaps that of the influenza B M
1 protein by 86 amino acids. This region could code for a maximum of 195 amino acids in the +2 reading frame, depending on whether or not the mRNA is spliced and the location of the initiating methionine residue. This region is likely to code for a protein analogous to the influenza A virus M
2 protein. No obvious homology has been detected in the deduced amino sequences of the M
2 proteins of the two viruses. The size of the M
1 coding regions is conserved between influenza A and B viruses, however the B virus segment 7 is larger, with the difference largely due to a longer M
2 coding region.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6278729</pmid><doi>10.1016/0042-6822(82)90150-7</doi><tpages>8</tpages></addata></record> |
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source | MEDLINE; Elsevier ScienceDirect Journals Complete; EZB-FREE-00999 freely available EZB journals |
subjects | Amino Acid Sequence Base Sequence DNA Restriction Enzymes Genes, Viral Genetic Code Humans influenza A virus Influenza A virus - genetics influenza B virus Models, Genetic Orthomyxoviridae - genetics Viral Matrix Proteins Viral Proteins - analysis Viral Proteins - genetics |
title | Sequence of RNA segment 7 of the influenza B virus genome: Partial amino acid homology between the membrane proteins (M 1) of Influenza A and B viruses and conservation of a second open reading frame |
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