Effects of Single Large Doses of Phenytoin on Glucose Homeostasis-a Preliminary Report
: The effects of a loading dose of 15 mg/kg phenytoin by iv infusion on the serum levels of insulin, glucagon, and glucose were investigated in five fasting healthy male volunteers between the ages of 23 and 35 years. Serum glucose concentrations rose immediately after the infusion of phenytoin foll...
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| Veröffentlicht in: | Journal of clinical pharmacology 1982-02, Vol.22 (2-3), p.79-81 |
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| container_end_page | 81 |
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| container_issue | 2-3 |
| container_start_page | 79 |
| container_title | Journal of clinical pharmacology |
| container_volume | 22 |
| creator | BANNER JR, WILLIAM JOHNSON, DAVID G. WALSON, PHILIP D. JUNG, DONALD |
| description | : The effects of a loading dose of 15 mg/kg phenytoin by iv infusion on the serum levels of insulin, glucagon, and glucose were investigated in five fasting healthy male volunteers between the ages of 23 and 35 years. Serum glucose concentrations rose immediately after the infusion of phenytoin followed by a significant increase in serum insulin values (P < 0.05). A slight elevation in mean glucagon concentrations after the infusion was not statistically significant. Further studies are indicated to determine whether phenytoin as used in the treatment of status epilepticus may aggravate the hyperglycemia associated with seizures. |
| doi_str_mv | 10.1002/j.1552-4604.1982.tb02652.x |
| format | Article |
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Serum glucose concentrations rose immediately after the infusion of phenytoin followed by a significant increase in serum insulin values (P < 0.05). A slight elevation in mean glucagon concentrations after the infusion was not statistically significant. Further studies are indicated to determine whether phenytoin as used in the treatment of status epilepticus may aggravate the hyperglycemia associated with seizures.</description><identifier>ISSN: 0091-2700</identifier><identifier>EISSN: 1552-4604</identifier><identifier>DOI: 10.1002/j.1552-4604.1982.tb02652.x</identifier><identifier>PMID: 7040499</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Blood Glucose - metabolism ; Glucagon - blood ; Homeostasis - drug effects ; Humans ; Insulin - pharmacology ; Male ; Phenytoin - pharmacology ; Time Factors</subject><ispartof>Journal of clinical pharmacology, 1982-02, Vol.22 (2-3), p.79-81</ispartof><rights>1982 American College of Clinical Pharmacology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4092-38dbf4b22e3793840330142ead0327c7d82df48f01d8aa3180d2fa7a0957faac3</citedby><cites>FETCH-LOGICAL-c4092-38dbf4b22e3793840330142ead0327c7d82df48f01d8aa3180d2fa7a0957faac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fj.1552-4604.1982.tb02652.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fj.1552-4604.1982.tb02652.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7040499$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BANNER JR, WILLIAM</creatorcontrib><creatorcontrib>JOHNSON, DAVID G.</creatorcontrib><creatorcontrib>WALSON, PHILIP D.</creatorcontrib><creatorcontrib>JUNG, DONALD</creatorcontrib><title>Effects of Single Large Doses of Phenytoin on Glucose Homeostasis-a Preliminary Report</title><title>Journal of clinical pharmacology</title><addtitle>J Clin Pharmacol</addtitle><description>: The effects of a loading dose of 15 mg/kg phenytoin by iv infusion on the serum levels of insulin, glucagon, and glucose were investigated in five fasting healthy male volunteers between the ages of 23 and 35 years. Serum glucose concentrations rose immediately after the infusion of phenytoin followed by a significant increase in serum insulin values (P < 0.05). A slight elevation in mean glucagon concentrations after the infusion was not statistically significant. Further studies are indicated to determine whether phenytoin as used in the treatment of status epilepticus may aggravate the hyperglycemia associated with seizures.</description><subject>Adult</subject><subject>Blood Glucose - metabolism</subject><subject>Glucagon - blood</subject><subject>Homeostasis - drug effects</subject><subject>Humans</subject><subject>Insulin - pharmacology</subject><subject>Male</subject><subject>Phenytoin - pharmacology</subject><subject>Time Factors</subject><issn>0091-2700</issn><issn>1552-4604</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE2P0zAQhi0EWsrCT0CyOHBLGH-kjjmBuksLqpaKBXZvlpuMF5ck7tqpaP89Ca165zTWvDPPWA8hbxjkDIC_2-SsKHgmpyBzpkue92vg04Ln-ydkco6ekgmAZhlXAM_Ji5Q2AGwqC3ZBLhRIkFpPyM9r57DqEw2O3vruoUG6tPEB6VVI-K-7-oXdoQ--o6Gj82ZXDQFdhBZD6m3yKbN0FbHxre9sPNBvuA2xf0meOdskfHWql-THp-vvs0W2_Dr_PPu4zCoJmmeirNdOrjlHobQoJQgBTHK0NQiuKlWXvHaydMDq0lrBSqi5s8qCLpSzthKX5O2Ru43hcYepN61PFTaN7TDsklESWFloOQy-Pw5WMaQU0Zlt9O3wYcPAjFLNxozmzGjOjFLNSarZD8uvT1d26xbr8-rJ4pB_OOZ_fIOH_yCbL7PVYnwOiOyI8KnH_Rlh428zVUIV5u5mbrS-l7dsdmOk-AtI15Yk</recordid><startdate>198202</startdate><enddate>198202</enddate><creator>BANNER JR, WILLIAM</creator><creator>JOHNSON, DAVID G.</creator><creator>WALSON, PHILIP D.</creator><creator>JUNG, DONALD</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198202</creationdate><title>Effects of Single Large Doses of Phenytoin on Glucose Homeostasis-a Preliminary Report</title><author>BANNER JR, WILLIAM ; JOHNSON, DAVID G. ; WALSON, PHILIP D. ; JUNG, DONALD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4092-38dbf4b22e3793840330142ead0327c7d82df48f01d8aa3180d2fa7a0957faac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Adult</topic><topic>Blood Glucose - metabolism</topic><topic>Glucagon - blood</topic><topic>Homeostasis - drug effects</topic><topic>Humans</topic><topic>Insulin - pharmacology</topic><topic>Male</topic><topic>Phenytoin - pharmacology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BANNER JR, WILLIAM</creatorcontrib><creatorcontrib>JOHNSON, DAVID G.</creatorcontrib><creatorcontrib>WALSON, PHILIP D.</creatorcontrib><creatorcontrib>JUNG, DONALD</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BANNER JR, WILLIAM</au><au>JOHNSON, DAVID G.</au><au>WALSON, PHILIP D.</au><au>JUNG, DONALD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Single Large Doses of Phenytoin on Glucose Homeostasis-a Preliminary Report</atitle><jtitle>Journal of clinical pharmacology</jtitle><addtitle>J Clin Pharmacol</addtitle><date>1982-02</date><risdate>1982</risdate><volume>22</volume><issue>2-3</issue><spage>79</spage><epage>81</epage><pages>79-81</pages><issn>0091-2700</issn><eissn>1552-4604</eissn><abstract>: The effects of a loading dose of 15 mg/kg phenytoin by iv infusion on the serum levels of insulin, glucagon, and glucose were investigated in five fasting healthy male volunteers between the ages of 23 and 35 years. Serum glucose concentrations rose immediately after the infusion of phenytoin followed by a significant increase in serum insulin values (P < 0.05). A slight elevation in mean glucagon concentrations after the infusion was not statistically significant. Further studies are indicated to determine whether phenytoin as used in the treatment of status epilepticus may aggravate the hyperglycemia associated with seizures.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>7040499</pmid><doi>10.1002/j.1552-4604.1982.tb02652.x</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-2700 |
| ispartof | Journal of clinical pharmacology, 1982-02, Vol.22 (2-3), p.79-81 |
| issn | 0091-2700 1552-4604 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Blood Glucose - metabolism Glucagon - blood Homeostasis - drug effects Humans Insulin - pharmacology Male Phenytoin - pharmacology Time Factors |
| title | Effects of Single Large Doses of Phenytoin on Glucose Homeostasis-a Preliminary Report |
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