Sequential Expression of Immunoglobulin on Developing Mouse B Lymphocytes: A Systematic Survey That Suggests a Model for the Generation of Immunoglobulin Isotype Diversity

Paired immunofluorescent staining with antibodies specific for the major isotypes of mouse immunoglobulin was used to study the ontogenetic expression of diversity of cell surface immunoglobulin. The first B lymphocytes to emerge, derived from cytoplasmic IgM+ precursors, express sIgM exclusively. B...

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Veröffentlicht in:	The Journal of immunology (1950) 1978-06, Vol.120 (6), p.2041-2049
Hauptverfasser:	Abney, Erika R, Cooper, Max D, Kearney, John F, Lawton, Alexander R, Parkhouse, R. M. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals B-Lymphocytes - immunology Fluorescent Antibody Technique Goats Immunoglobulin A Immunoglobulin Allotypes Immunoglobulin D Immunoglobulin M Mice Mice, Inbred BALB C Mice, Inbred CBA Models, Biological Rabbits Receptors, Antigen, B-Cell Time Factors
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