Metabolism and Excretion of Normorphine in Dogs
Normorphine metabolism was studied in dogs given 20 mg of normorphine hydrochloride/kg sc. Free and conjugated normorphine excreted in the urine over 144 hr represented 32 and 32%, respectively, of the administered dose. Eighty percent of the urinary excretion of the drug occurred within 9 hr. One p...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1978-06, Vol.67 (6), p.878-880 |
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| container_title | Journal of pharmaceutical sciences |
| container_volume | 67 |
| creator | Yeh, S.Y. McQuinn, R.L. Krebs, H.A. Gorodetzky, C.W. |
| description | Normorphine metabolism was studied in dogs given 20 mg of normorphine hydrochloride/kg sc. Free and conjugated normorphine excreted in the urine over 144 hr represented 32 and 32%, respectively, of the administered dose. Eighty percent of the urinary excretion of the drug occurred within 9 hr. One percent of the administered dose was excreted as free normorphine in the feces. The urine was chromatographed on a column. Evaporation of the washing and methanolic effluent yielded a residue, which was purified by crystallization from aqueous methanol. Results of UV and IR studies, elemental analysis, and determination of normorphine and glucuronic acid content established the identity of this metabolite as normorphine 3-glucuronide. Dihydronormorphine and dehydronormorphine were detected with GLC–mass spectrometry as minor metabolites. |
| doi_str_mv | 10.1002/jps.2600670646 |
| format | Article |
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Free and conjugated normorphine excreted in the urine over 144 hr represented 32 and 32%, respectively, of the administered dose. Eighty percent of the urinary excretion of the drug occurred within 9 hr. One percent of the administered dose was excreted as free normorphine in the feces. The urine was chromatographed on a column. Evaporation of the washing and methanolic effluent yielded a residue, which was purified by crystallization from aqueous methanol. Results of UV and IR studies, elemental analysis, and determination of normorphine and glucuronic acid content established the identity of this metabolite as normorphine 3-glucuronide. Dihydronormorphine and dehydronormorphine were detected with GLC–mass spectrometry as minor metabolites.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600670646</identifier><identifier>PMID: 660482</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Animals ; Chromatography, Gas ; Dealkylation ; Dogs ; Excretion-normorphine in dogs ; Feces - analysis ; Female ; Mass Spectrometry ; metabolism and excretion in dogs ; Metabolism-normorphine in dogs ; Morphine Derivatives - metabolism ; Morphine Derivatives - urine ; Narcotic analgesics-normorphine ; Narcotic analgesics—normorphine, metabolism and excretion in Dogs ; Normorphine-metabolism and excretion in dogs</subject><ispartof>Journal of pharmaceutical sciences, 1978-06, Vol.67 (6), p.878-880</ispartof><rights>1978 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1978 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4266-2e1fd075393aa78525d9822ef35822b1649d6b4e3aa09f55e5320b6c5349c7323</citedby><cites>FETCH-LOGICAL-c4266-2e1fd075393aa78525d9822ef35822b1649d6b4e3aa09f55e5320b6c5349c7323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600670646$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600670646$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/660482$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yeh, S.Y.</creatorcontrib><creatorcontrib>McQuinn, R.L.</creatorcontrib><creatorcontrib>Krebs, H.A.</creatorcontrib><creatorcontrib>Gorodetzky, C.W.</creatorcontrib><title>Metabolism and Excretion of Normorphine in Dogs</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>Normorphine metabolism was studied in dogs given 20 mg of normorphine hydrochloride/kg sc. Free and conjugated normorphine excreted in the urine over 144 hr represented 32 and 32%, respectively, of the administered dose. Eighty percent of the urinary excretion of the drug occurred within 9 hr. One percent of the administered dose was excreted as free normorphine in the feces. The urine was chromatographed on a column. Evaporation of the washing and methanolic effluent yielded a residue, which was purified by crystallization from aqueous methanol. Results of UV and IR studies, elemental analysis, and determination of normorphine and glucuronic acid content established the identity of this metabolite as normorphine 3-glucuronide. Dihydronormorphine and dehydronormorphine were detected with GLC–mass spectrometry as minor metabolites.</description><subject>Animals</subject><subject>Chromatography, Gas</subject><subject>Dealkylation</subject><subject>Dogs</subject><subject>Excretion-normorphine in dogs</subject><subject>Feces - analysis</subject><subject>Female</subject><subject>Mass Spectrometry</subject><subject>metabolism and excretion in dogs</subject><subject>Metabolism-normorphine in dogs</subject><subject>Morphine Derivatives - metabolism</subject><subject>Morphine Derivatives - urine</subject><subject>Narcotic analgesics-normorphine</subject><subject>Narcotic analgesics—normorphine, metabolism and excretion in Dogs</subject><subject>Normorphine-metabolism and excretion in dogs</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDlPwzAYhi3EVY6ViSETW1ofsdOMqLRcpSDO0UqcL-CSxMFOOf49RqlADIjpG97nfSy_CO0R3CcY08G8cX0qMBYxFpFYQT3CKQ4FJvEq6nmAhoxHySbacm6OPYY530DrQuBoSHtocAFtmplSuypI6zwYvysLrTZ1YIpgZmxlbPOkawh0HRyZR7eD1oq0dLC7vNvobjK-HZ2E08vj09HhNFQRFSKkQIocx5wlLE3jIac8T4aUQsG4PxkRUZKLLAKf4qTgHDijOBOKsyhRMaNsGx103saalwW4VlbaKSjLtAazcDKOMGFe48F-ByprnLNQyMbqKrUfkmD5NZD0A8mfgXxhf2leZBXk33i3iI-TLn7TJXz8I5NnVze_1GHX1a6F9-9uap-liFnM5cPsWE7I-Qm_v7iWX28NOx78kq8arHRKQ60g1xZUK3Oj__rFJ8jFkQI</recordid><startdate>197806</startdate><enddate>197806</enddate><creator>Yeh, S.Y.</creator><creator>McQuinn, R.L.</creator><creator>Krebs, H.A.</creator><creator>Gorodetzky, C.W.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197806</creationdate><title>Metabolism and Excretion of Normorphine in Dogs</title><author>Yeh, S.Y. ; McQuinn, R.L. ; Krebs, H.A. ; Gorodetzky, C.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4266-2e1fd075393aa78525d9822ef35822b1649d6b4e3aa09f55e5320b6c5349c7323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Animals</topic><topic>Chromatography, Gas</topic><topic>Dealkylation</topic><topic>Dogs</topic><topic>Excretion-normorphine in dogs</topic><topic>Feces - analysis</topic><topic>Female</topic><topic>Mass Spectrometry</topic><topic>metabolism and excretion in dogs</topic><topic>Metabolism-normorphine in dogs</topic><topic>Morphine Derivatives - metabolism</topic><topic>Morphine Derivatives - urine</topic><topic>Narcotic analgesics-normorphine</topic><topic>Narcotic analgesics—normorphine, metabolism and excretion in Dogs</topic><topic>Normorphine-metabolism and excretion in dogs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yeh, S.Y.</creatorcontrib><creatorcontrib>McQuinn, R.L.</creatorcontrib><creatorcontrib>Krebs, H.A.</creatorcontrib><creatorcontrib>Gorodetzky, C.W.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yeh, S.Y.</au><au>McQuinn, R.L.</au><au>Krebs, H.A.</au><au>Gorodetzky, C.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolism and Excretion of Normorphine in Dogs</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1978-06</date><risdate>1978</risdate><volume>67</volume><issue>6</issue><spage>878</spage><epage>880</epage><pages>878-880</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>Normorphine metabolism was studied in dogs given 20 mg of normorphine hydrochloride/kg sc. Free and conjugated normorphine excreted in the urine over 144 hr represented 32 and 32%, respectively, of the administered dose. Eighty percent of the urinary excretion of the drug occurred within 9 hr. One percent of the administered dose was excreted as free normorphine in the feces. The urine was chromatographed on a column. Evaporation of the washing and methanolic effluent yielded a residue, which was purified by crystallization from aqueous methanol. Results of UV and IR studies, elemental analysis, and determination of normorphine and glucuronic acid content established the identity of this metabolite as normorphine 3-glucuronide. Dihydronormorphine and dehydronormorphine were detected with GLC–mass spectrometry as minor metabolites.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>660482</pmid><doi>10.1002/jps.2600670646</doi><tpages>3</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical sciences, 1978-06, Vol.67 (6), p.878-880 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | MEDLINE; Wiley Online Library; Alma/SFX Local Collection |
| subjects | Animals Chromatography, Gas Dealkylation Dogs Excretion-normorphine in dogs Feces - analysis Female Mass Spectrometry metabolism and excretion in dogs Metabolism-normorphine in dogs Morphine Derivatives - metabolism Morphine Derivatives - urine Narcotic analgesics-normorphine Narcotic analgesics—normorphine, metabolism and excretion in Dogs Normorphine-metabolism and excretion in dogs |
| title | Metabolism and Excretion of Normorphine in Dogs |
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