A serial study of splenic reticuloendothelial system fc receptor functional activity in systemic lupus erythematosus
A serial study of reticuloendothelial system splenic Fc receptor function was undertaken in 13 patients with systemic lupus erythematosus (SLE). Fc receptor function was assessed by measuring the clearance half‐times of IgG‐sensitized 51Cr‐labeled autologous erythrocytes from the circulation. Prolon...
Gespeichert in:
| Veröffentlicht in: | Arthritis and rheumatism 1982-01, Vol.25 (1), p.48-54 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 54 |
|---|---|
| container_issue | 1 |
| container_start_page | 48 |
| container_title | Arthritis and rheumatism |
| container_volume | 25 |
| creator | Hamburger, Max I. Lawley, Thomas J. Kimberly, Robert P. Plotz, Paul H. Frank, Michael M. |
| description | A serial study of reticuloendothelial system splenic Fc receptor function was undertaken in 13 patients with systemic lupus erythematosus (SLE). Fc receptor function was assessed by measuring the clearance half‐times of IgG‐sensitized 51Cr‐labeled autologous erythrocytes from the circulation. Prolonged clearance half‐times were intially detected in all patients, and the magnitude of the clearance defect was significantly correlated with disease activity (P < 0.01, Spearman rank correlation) and immune complex levels (P < 0.01). Clinical course and changes in receptor functional activity over time were found to be significantly correlated. Clearance half‐times tended to return to normal in all 11 patients who clinically improved. The clearance half‐time remained unchanged in 1 patient whose disease activity was stable, and it worsened in 1 patient whose illness flared. Levels of immune complexes also changed concordantly with clearance half‐times and disease activity. These studies underscore the interrelationship between the presence of circulating immune complexes, defects in Fc receptor function that might lead to prolonged circulation of these complexes, and disease activity in SLE. |
| doi_str_mv | 10.1002/art.1780250108 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_74011953</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>15425274</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4118-cd0e3c9796c449a637db733d2d98423b60964db763dfcad4f686de5331b3a9de3</originalsourceid><addsrcrecordid>eNqFkTtLBDEURoMouj5aOyGV3azJJPNIuYgvEATResgmdzCSmYx5KPPvje6idlY3N9-5p_kQOqVkSQkpL6SPS9q0pKwIJe0OWtCqFAWhjO6iBSGEF6wS9AAdhvCa15JVbB_t16JpKeMLFFc4gDfS4hCTnrHrcZgsjEZhD9GoZB2M2sUXsN_QHCIMuP9KFUzRedynUUXjxpzK_Hg3ccZm3JJZY9OUAgY_Z8cgowspHKO9XtoAJ9t5hJ6vr54ub4v7h5u7y9V9oTilbaE0AaZEI2rFuZA1a_S6YUyXWrS8ZOuaiJrnr5rpXknN-7qtNVSM0TWTQgM7Qucb7-TdW4IQu8EEBdbKEVwKXcMJpSIf_AfSipdV2fAMLjeg8i4ED303eTNIP3eUdF99dLmP7rePfHC2Naf1APoH3xaQc7HJP4yF-R9bt3p8-uP-BDEOmds</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15425274</pqid></control><display><type>article</type><title>A serial study of splenic reticuloendothelial system fc receptor functional activity in systemic lupus erythematosus</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Alma/SFX Local Collection</source><creator>Hamburger, Max I. ; Lawley, Thomas J. ; Kimberly, Robert P. ; Plotz, Paul H. ; Frank, Michael M.</creator><creatorcontrib>Hamburger, Max I. ; Lawley, Thomas J. ; Kimberly, Robert P. ; Plotz, Paul H. ; Frank, Michael M.</creatorcontrib><description>A serial study of reticuloendothelial system splenic Fc receptor function was undertaken in 13 patients with systemic lupus erythematosus (SLE). Fc receptor function was assessed by measuring the clearance half‐times of IgG‐sensitized 51Cr‐labeled autologous erythrocytes from the circulation. Prolonged clearance half‐times were intially detected in all patients, and the magnitude of the clearance defect was significantly correlated with disease activity (P < 0.01, Spearman rank correlation) and immune complex levels (P < 0.01). Clinical course and changes in receptor functional activity over time were found to be significantly correlated. Clearance half‐times tended to return to normal in all 11 patients who clinically improved. The clearance half‐time remained unchanged in 1 patient whose disease activity was stable, and it worsened in 1 patient whose illness flared. Levels of immune complexes also changed concordantly with clearance half‐times and disease activity. These studies underscore the interrelationship between the presence of circulating immune complexes, defects in Fc receptor function that might lead to prolonged circulation of these complexes, and disease activity in SLE.</description><identifier>ISSN: 0004-3591</identifier><identifier>EISSN: 1529-0131</identifier><identifier>DOI: 10.1002/art.1780250108</identifier><identifier>PMID: 6978134</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Adult ; Antibodies, Antinuclear - analysis ; Antigen-Antibody Complex - analysis ; Complement C1 - metabolism ; DNA - immunology ; Erythrocytes - immunology ; Female ; Humans ; Immunoglobulin G - metabolism ; Lupus Erythematosus, Systemic - immunology ; Middle Aged ; Mononuclear Phagocyte System - immunology ; Receptors, Fc - physiology ; Spleen - immunology ; Spleen - physiopathology ; Time Factors</subject><ispartof>Arthritis and rheumatism, 1982-01, Vol.25 (1), p.48-54</ispartof><rights>Copyright © 1982 American College of Rheumatology</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4118-cd0e3c9796c449a637db733d2d98423b60964db763dfcad4f686de5331b3a9de3</citedby><cites>FETCH-LOGICAL-c4118-cd0e3c9796c449a637db733d2d98423b60964db763dfcad4f686de5331b3a9de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fart.1780250108$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fart.1780250108$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6978134$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hamburger, Max I.</creatorcontrib><creatorcontrib>Lawley, Thomas J.</creatorcontrib><creatorcontrib>Kimberly, Robert P.</creatorcontrib><creatorcontrib>Plotz, Paul H.</creatorcontrib><creatorcontrib>Frank, Michael M.</creatorcontrib><title>A serial study of splenic reticuloendothelial system fc receptor functional activity in systemic lupus erythematosus</title><title>Arthritis and rheumatism</title><addtitle>Arthritis Rheum</addtitle><description>A serial study of reticuloendothelial system splenic Fc receptor function was undertaken in 13 patients with systemic lupus erythematosus (SLE). Fc receptor function was assessed by measuring the clearance half‐times of IgG‐sensitized 51Cr‐labeled autologous erythrocytes from the circulation. Prolonged clearance half‐times were intially detected in all patients, and the magnitude of the clearance defect was significantly correlated with disease activity (P < 0.01, Spearman rank correlation) and immune complex levels (P < 0.01). Clinical course and changes in receptor functional activity over time were found to be significantly correlated. Clearance half‐times tended to return to normal in all 11 patients who clinically improved. The clearance half‐time remained unchanged in 1 patient whose disease activity was stable, and it worsened in 1 patient whose illness flared. Levels of immune complexes also changed concordantly with clearance half‐times and disease activity. These studies underscore the interrelationship between the presence of circulating immune complexes, defects in Fc receptor function that might lead to prolonged circulation of these complexes, and disease activity in SLE.</description><subject>Adult</subject><subject>Antibodies, Antinuclear - analysis</subject><subject>Antigen-Antibody Complex - analysis</subject><subject>Complement C1 - metabolism</subject><subject>DNA - immunology</subject><subject>Erythrocytes - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin G - metabolism</subject><subject>Lupus Erythematosus, Systemic - immunology</subject><subject>Middle Aged</subject><subject>Mononuclear Phagocyte System - immunology</subject><subject>Receptors, Fc - physiology</subject><subject>Spleen - immunology</subject><subject>Spleen - physiopathology</subject><subject>Time Factors</subject><issn>0004-3591</issn><issn>1529-0131</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTtLBDEURoMouj5aOyGV3azJJPNIuYgvEATResgmdzCSmYx5KPPvje6idlY3N9-5p_kQOqVkSQkpL6SPS9q0pKwIJe0OWtCqFAWhjO6iBSGEF6wS9AAdhvCa15JVbB_t16JpKeMLFFc4gDfS4hCTnrHrcZgsjEZhD9GoZB2M2sUXsN_QHCIMuP9KFUzRedynUUXjxpzK_Hg3ccZm3JJZY9OUAgY_Z8cgowspHKO9XtoAJ9t5hJ6vr54ub4v7h5u7y9V9oTilbaE0AaZEI2rFuZA1a_S6YUyXWrS8ZOuaiJrnr5rpXknN-7qtNVSM0TWTQgM7Qucb7-TdW4IQu8EEBdbKEVwKXcMJpSIf_AfSipdV2fAMLjeg8i4ED303eTNIP3eUdF99dLmP7rePfHC2Naf1APoH3xaQc7HJP4yF-R9bt3p8-uP-BDEOmds</recordid><startdate>198201</startdate><enddate>198201</enddate><creator>Hamburger, Max I.</creator><creator>Lawley, Thomas J.</creator><creator>Kimberly, Robert P.</creator><creator>Plotz, Paul H.</creator><creator>Frank, Michael M.</creator><general>John Wiley & Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>198201</creationdate><title>A serial study of splenic reticuloendothelial system fc receptor functional activity in systemic lupus erythematosus</title><author>Hamburger, Max I. ; Lawley, Thomas J. ; Kimberly, Robert P. ; Plotz, Paul H. ; Frank, Michael M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4118-cd0e3c9796c449a637db733d2d98423b60964db763dfcad4f686de5331b3a9de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Adult</topic><topic>Antibodies, Antinuclear - analysis</topic><topic>Antigen-Antibody Complex - analysis</topic><topic>Complement C1 - metabolism</topic><topic>DNA - immunology</topic><topic>Erythrocytes - immunology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin G - metabolism</topic><topic>Lupus Erythematosus, Systemic - immunology</topic><topic>Middle Aged</topic><topic>Mononuclear Phagocyte System - immunology</topic><topic>Receptors, Fc - physiology</topic><topic>Spleen - immunology</topic><topic>Spleen - physiopathology</topic><topic>Time Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Hamburger, Max I.</creatorcontrib><creatorcontrib>Lawley, Thomas J.</creatorcontrib><creatorcontrib>Kimberly, Robert P.</creatorcontrib><creatorcontrib>Plotz, Paul H.</creatorcontrib><creatorcontrib>Frank, Michael M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Arthritis and rheumatism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hamburger, Max I.</au><au>Lawley, Thomas J.</au><au>Kimberly, Robert P.</au><au>Plotz, Paul H.</au><au>Frank, Michael M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A serial study of splenic reticuloendothelial system fc receptor functional activity in systemic lupus erythematosus</atitle><jtitle>Arthritis and rheumatism</jtitle><addtitle>Arthritis Rheum</addtitle><date>1982-01</date><risdate>1982</risdate><volume>25</volume><issue>1</issue><spage>48</spage><epage>54</epage><pages>48-54</pages><issn>0004-3591</issn><eissn>1529-0131</eissn><abstract>A serial study of reticuloendothelial system splenic Fc receptor function was undertaken in 13 patients with systemic lupus erythematosus (SLE). Fc receptor function was assessed by measuring the clearance half‐times of IgG‐sensitized 51Cr‐labeled autologous erythrocytes from the circulation. Prolonged clearance half‐times were intially detected in all patients, and the magnitude of the clearance defect was significantly correlated with disease activity (P < 0.01, Spearman rank correlation) and immune complex levels (P < 0.01). Clinical course and changes in receptor functional activity over time were found to be significantly correlated. Clearance half‐times tended to return to normal in all 11 patients who clinically improved. The clearance half‐time remained unchanged in 1 patient whose disease activity was stable, and it worsened in 1 patient whose illness flared. Levels of immune complexes also changed concordantly with clearance half‐times and disease activity. These studies underscore the interrelationship between the presence of circulating immune complexes, defects in Fc receptor function that might lead to prolonged circulation of these complexes, and disease activity in SLE.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>6978134</pmid><doi>10.1002/art.1780250108</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0004-3591 |
| ispartof | Arthritis and rheumatism, 1982-01, Vol.25 (1), p.48-54 |
| issn | 0004-3591 1529-0131 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74011953 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Adult Antibodies, Antinuclear - analysis Antigen-Antibody Complex - analysis Complement C1 - metabolism DNA - immunology Erythrocytes - immunology Female Humans Immunoglobulin G - metabolism Lupus Erythematosus, Systemic - immunology Middle Aged Mononuclear Phagocyte System - immunology Receptors, Fc - physiology Spleen - immunology Spleen - physiopathology Time Factors |
| title | A serial study of splenic reticuloendothelial system fc receptor functional activity in systemic lupus erythematosus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T11%3A07%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20serial%20study%20of%20splenic%20reticuloendothelial%20system%20fc%20receptor%20functional%20activity%20in%20systemic%20lupus%20erythematosus&rft.jtitle=Arthritis%20and%20rheumatism&rft.au=Hamburger,%20Max%20I.&rft.date=1982-01&rft.volume=25&rft.issue=1&rft.spage=48&rft.epage=54&rft.pages=48-54&rft.issn=0004-3591&rft.eissn=1529-0131&rft_id=info:doi/10.1002/art.1780250108&rft_dat=%3Cproquest_cross%3E15425274%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15425274&rft_id=info:pmid/6978134&rfr_iscdi=true |