ALTERATION OF LYMPHOID CELLS IN AKR MICE BY TREATMENT WITH MONOCLONAL ANTIBODY AGAINST THY-1 ANTIGEN
AKR/J mice treated with high levels of monoclonal anti-Thy-1.1 antibody and C remained healthy without apparent side effects. Examination of the lymphatic organs of these mice demonstrated a selective depletion of T cells in lymph nodes and spleen. Following cessation of treatment of the levels of a...
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| Veröffentlicht in: | Transplantation 1982-03, Vol.33 (3), p.269-273 |
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| creator | TAM, MILTON R BERNSTEIN, IRWIN D NOWINSKI, ROBERT C |
| description | AKR/J mice treated with high levels of monoclonal anti-Thy-1.1 antibody and C remained healthy without apparent side effects. Examination of the lymphatic organs of these mice demonstrated a selective depletion of T cells in lymph nodes and spleen. Following cessation of treatment of the levels of anti-Thy-1.1 antibody in the circulation fell and the peripheral lymphatic organs gradually became repopulated with T cells. Depletion occurred in lymph nodes whether or not C was infused along with the antibody. Although the thymocytes of these mice were coated with anti-Thy-1.1 antibody they were not eliminated by the treatment. The elimination of peripheral but not thymic T cells suggests either a thymic barrier to the penetration of cofactors (possibly antibody-dependent effector cells) or that antibody acts by interfering with the normal traffic of peripheral T cells which normally “home” to the lymph nodes and spleen. |
| doi_str_mv | 10.1097/00007890-198203000-00012 |
| format | Article |
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Examination of the lymphatic organs of these mice demonstrated a selective depletion of T cells in lymph nodes and spleen. Following cessation of treatment of the levels of anti-Thy-1.1 antibody in the circulation fell and the peripheral lymphatic organs gradually became repopulated with T cells. Depletion occurred in lymph nodes whether or not C was infused along with the antibody. Although the thymocytes of these mice were coated with anti-Thy-1.1 antibody they were not eliminated by the treatment. The elimination of peripheral but not thymic T cells suggests either a thymic barrier to the penetration of cofactors (possibly antibody-dependent effector cells) or that antibody acts by interfering with the normal traffic of peripheral T cells which normally “home” to the lymph nodes and spleen.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/00007890-198203000-00012</identifier><identifier>PMID: 6121406</identifier><language>eng</language><publisher>United States: Copyright Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Animals ; Antibodies, Monoclonal - immunology ; Antigen-Antibody Reactions ; Antigens, Surface - immunology ; Complement System Proteins - metabolism ; Cytotoxicity, Immunologic ; Leukocyte Count ; Membrane Proteins - immunology ; Mice ; Mice, Inbred A ; Mice, Inbred AKR - immunology ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Rabbits ; T-Lymphocytes - immunology ; Thy-1 Antigens</subject><ispartof>Transplantation, 1982-03, Vol.33 (3), p.269-273</ispartof><rights>Copyright © 1982 Wolters Kluwer Health, Inc. 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Examination of the lymphatic organs of these mice demonstrated a selective depletion of T cells in lymph nodes and spleen. Following cessation of treatment of the levels of anti-Thy-1.1 antibody in the circulation fell and the peripheral lymphatic organs gradually became repopulated with T cells. Depletion occurred in lymph nodes whether or not C was infused along with the antibody. Although the thymocytes of these mice were coated with anti-Thy-1.1 antibody they were not eliminated by the treatment. The elimination of peripheral but not thymic T cells suggests either a thymic barrier to the penetration of cofactors (possibly antibody-dependent effector cells) or that antibody acts by interfering with the normal traffic of peripheral T cells which normally “home” to the lymph nodes and spleen.</description><subject>Animals</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antigen-Antibody Reactions</subject><subject>Antigens, Surface - immunology</subject><subject>Complement System Proteins - metabolism</subject><subject>Cytotoxicity, Immunologic</subject><subject>Leukocyte Count</subject><subject>Membrane Proteins - immunology</subject><subject>Mice</subject><subject>Mice, Inbred A</subject><subject>Mice, Inbred AKR - immunology</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Rabbits</subject><subject>T-Lymphocytes - immunology</subject><subject>Thy-1 Antigens</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1PwyAUhonR6Pz4CSZceVflAKXtJda6NXatmRizK8I2iB-dm2WL8d-LbnpnJCEEzvNCOA9CGMg5kCy5IGEkaUYiyFJKWNhFYQLdQT2IGY8EScku6hHCIQLGkgN06P1zQGKWJPtoXwAFTkQPzWSlipFUZVPj5hpX4-HtoCmvcF5U1R0uayxvRnhY5gW-HGM1KqQaFrXCD6Ua4GFTN3nV1LLCslblZXM1xrIvy_pOYTUYR_B93C_qY7TnTOvtyXY9QvfXhcoHUdX0y1xW0ZQzQSMKmYkdmznqHHDjXMaTmZgQQ60jYCGdWLBGZCkxjNCEB5qHzCQNP7aCx-wInW3uXXaLt7X1Kz1_8lPbtubVLtZeJzw0gDLxLwgxzxgVJIDpBpx2C-876_Sye5qb7kMD0V8m9I8J_WtCf5sI0dPtG-vJ3M5-g9vWhzrf1N8X7cp2_qVdv9tOP1rTrh71X4LZJ8xKiMA</recordid><startdate>198203</startdate><enddate>198203</enddate><creator>TAM, MILTON R</creator><creator>BERNSTEIN, IRWIN D</creator><creator>NOWINSKI, ROBERT C</creator><general>Copyright Wolters Kluwer Health, Inc. All rights reserved</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>198203</creationdate><title>ALTERATION OF LYMPHOID CELLS IN AKR MICE BY TREATMENT WITH MONOCLONAL ANTIBODY AGAINST THY-1 ANTIGEN</title><author>TAM, MILTON R ; BERNSTEIN, IRWIN D ; NOWINSKI, ROBERT C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4362-219a5f3df2ff14aff947d6b0a2ef01e18be1ea6980a302749a54219b8534e6453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Antigen-Antibody Reactions</topic><topic>Antigens, Surface - immunology</topic><topic>Complement System Proteins - metabolism</topic><topic>Cytotoxicity, Immunologic</topic><topic>Leukocyte Count</topic><topic>Membrane Proteins - immunology</topic><topic>Mice</topic><topic>Mice, Inbred A</topic><topic>Mice, Inbred AKR - immunology</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Rabbits</topic><topic>T-Lymphocytes - immunology</topic><topic>Thy-1 Antigens</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TAM, MILTON R</creatorcontrib><creatorcontrib>BERNSTEIN, IRWIN D</creatorcontrib><creatorcontrib>NOWINSKI, ROBERT C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TAM, MILTON R</au><au>BERNSTEIN, IRWIN D</au><au>NOWINSKI, ROBERT C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ALTERATION OF LYMPHOID CELLS IN AKR MICE BY TREATMENT WITH MONOCLONAL ANTIBODY AGAINST THY-1 ANTIGEN</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>1982-03</date><risdate>1982</risdate><volume>33</volume><issue>3</issue><spage>269</spage><epage>273</epage><pages>269-273</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><abstract>AKR/J mice treated with high levels of monoclonal anti-Thy-1.1 antibody and C remained healthy without apparent side effects. Examination of the lymphatic organs of these mice demonstrated a selective depletion of T cells in lymph nodes and spleen. Following cessation of treatment of the levels of anti-Thy-1.1 antibody in the circulation fell and the peripheral lymphatic organs gradually became repopulated with T cells. Depletion occurred in lymph nodes whether or not C was infused along with the antibody. Although the thymocytes of these mice were coated with anti-Thy-1.1 antibody they were not eliminated by the treatment. The elimination of peripheral but not thymic T cells suggests either a thymic barrier to the penetration of cofactors (possibly antibody-dependent effector cells) or that antibody acts by interfering with the normal traffic of peripheral T cells which normally “home” to the lymph nodes and spleen.</abstract><cop>United States</cop><pub>Copyright Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>6121406</pmid><doi>10.1097/00007890-198203000-00012</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-1337 |
| ispartof | Transplantation, 1982-03, Vol.33 (3), p.269-273 |
| issn | 0041-1337 1534-6080 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Antibodies, Monoclonal - immunology Antigen-Antibody Reactions Antigens, Surface - immunology Complement System Proteins - metabolism Cytotoxicity, Immunologic Leukocyte Count Membrane Proteins - immunology Mice Mice, Inbred A Mice, Inbred AKR - immunology Mice, Inbred BALB C Mice, Inbred C57BL Rabbits T-Lymphocytes - immunology Thy-1 Antigens |
| title | ALTERATION OF LYMPHOID CELLS IN AKR MICE BY TREATMENT WITH MONOCLONAL ANTIBODY AGAINST THY-1 ANTIGEN |
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