Sequential perioperative lactate determination. Physiological and clinical implications
Sequential arterial blood lactate concentrations were determined pre-, intra-, and postoperatively in 12 high risk surgical patients. These levels were correlated with simultaneous measurements of arterial blood pressure, cardiac index (CI), and oxygen consumption (Vo2). There was a marked increase...
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| Veröffentlicht in: | Critical care medicine 1982-02, Vol.10 (2), p.96-99 |
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| creator | WAXMAN, KENNETH NOLAN, LORENE S SHOEMAKER, WILLIAM C |
| description | Sequential arterial blood lactate concentrations were determined pre-, intra-, and postoperatively in 12 high risk surgical patients. These levels were correlated with simultaneous measurements of arterial blood pressure, cardiac index (CI), and oxygen consumption (Vo2). There was a marked increase in lactate values intraoperatively. This increase did not correspond to decreases in either mean arterial pressure (MAP) or CI, but did appear to correlate with decreased intraoperative Vo2. Postoperatively, lactate levels remained elevated, and this elevation appeared to correlate with an estimation of intraoperative oxygen deficit. CI and Vo2 were increased postoperatively; the data support the hypothesis that these postoperative increases in CI and Vo2 represent physiological compensations for intraoperative oxygen deficits. Clinically, determinations of lactate values may prove useful in titrating postoperative therapy to support needed physiological compensations. |
| doi_str_mv | 10.1097/00003246-198202000-00005 |
| format | Article |
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CI and Vo2 were increased postoperatively; the data support the hypothesis that these postoperative increases in CI and Vo2 represent physiological compensations for intraoperative oxygen deficits. Clinically, determinations of lactate values may prove useful in titrating postoperative therapy to support needed physiological compensations.</description><identifier>ISSN: 0090-3493</identifier><identifier>EISSN: 1530-0293</identifier><identifier>DOI: 10.1097/00003246-198202000-00005</identifier><identifier>PMID: 7060384</identifier><language>eng</language><publisher>United States: Williams & Wilkins</publisher><subject>Adult ; Aged ; Blood Pressure ; Cardiac Output ; Female ; Humans ; Intraoperative Period ; Lactates - blood ; Male ; Middle Aged ; Oxygen Consumption ; Postoperative Care ; Postoperative Period</subject><ispartof>Critical care medicine, 1982-02, Vol.10 (2), p.96-99</ispartof><rights>Williams & Wilkins 1982. 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Physiological and clinical implications</title><title>Critical care medicine</title><addtitle>Crit Care Med</addtitle><description>Sequential arterial blood lactate concentrations were determined pre-, intra-, and postoperatively in 12 high risk surgical patients. These levels were correlated with simultaneous measurements of arterial blood pressure, cardiac index (CI), and oxygen consumption (Vo2). There was a marked increase in lactate values intraoperatively. This increase did not correspond to decreases in either mean arterial pressure (MAP) or CI, but did appear to correlate with decreased intraoperative Vo2. Postoperatively, lactate levels remained elevated, and this elevation appeared to correlate with an estimation of intraoperative oxygen deficit. CI and Vo2 were increased postoperatively; the data support the hypothesis that these postoperative increases in CI and Vo2 represent physiological compensations for intraoperative oxygen deficits. Clinically, determinations of lactate values may prove useful in titrating postoperative therapy to support needed physiological compensations.</description><subject>Adult</subject><subject>Aged</subject><subject>Blood Pressure</subject><subject>Cardiac Output</subject><subject>Female</subject><subject>Humans</subject><subject>Intraoperative Period</subject><subject>Lactates - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oxygen Consumption</subject><subject>Postoperative Care</subject><subject>Postoperative Period</subject><issn>0090-3493</issn><issn>1530-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UV1PwyAUJUYz5_QnmPTJt04opcCjWfxKlmiixkdC6a1D6Yelddm_l25zb_JwuefccyAcEIoInhMs-TUOiyZpFhMpEpwEFI8UO0JTwmgAiaTHaIqxxDFNJT1FZ95_YkxSxukETTjOMBXpFL2_wPcAdW-1i1robBOK7u0PRE6bXvcQFdBDV9k6sE09j55XG28b13xYEyy6LiLjbL0FtmpdaEadP0cnpXYeLvb7DL3d3b4uHuLl0_3j4mYZG8oYiw0GQbnkZcZSwjmlmueECp4bU-YZlJRlXLMk1CIrRMF4kQLgRMu8NJlICzpDV7tz264JD_G9qqw34JyuoRm84lRKkXEWhGInNF3jfQelajtb6W6jCFZjpuovU3XIdEuN1sv9HUNeQXEw7kMM83Q3XzcuZOW_3LCGTq1Au36l_vsq-guvn4K2</recordid><startdate>198202</startdate><enddate>198202</enddate><creator>WAXMAN, KENNETH</creator><creator>NOLAN, LORENE S</creator><creator>SHOEMAKER, WILLIAM C</creator><general>Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198202</creationdate><title>Sequential perioperative lactate determination. Physiological and clinical implications</title><author>WAXMAN, KENNETH ; NOLAN, LORENE S ; SHOEMAKER, WILLIAM C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3555-c0e83797f65417733a7b1387bccfb6ef3567a52567d6d8d57d4ee02a9bfc684d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Blood Pressure</topic><topic>Cardiac Output</topic><topic>Female</topic><topic>Humans</topic><topic>Intraoperative Period</topic><topic>Lactates - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oxygen Consumption</topic><topic>Postoperative Care</topic><topic>Postoperative Period</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WAXMAN, KENNETH</creatorcontrib><creatorcontrib>NOLAN, LORENE S</creatorcontrib><creatorcontrib>SHOEMAKER, WILLIAM C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WAXMAN, KENNETH</au><au>NOLAN, LORENE S</au><au>SHOEMAKER, WILLIAM C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sequential perioperative lactate determination. Physiological and clinical implications</atitle><jtitle>Critical care medicine</jtitle><addtitle>Crit Care Med</addtitle><date>1982-02</date><risdate>1982</risdate><volume>10</volume><issue>2</issue><spage>96</spage><epage>99</epage><pages>96-99</pages><issn>0090-3493</issn><eissn>1530-0293</eissn><abstract>Sequential arterial blood lactate concentrations were determined pre-, intra-, and postoperatively in 12 high risk surgical patients. These levels were correlated with simultaneous measurements of arterial blood pressure, cardiac index (CI), and oxygen consumption (Vo2). There was a marked increase in lactate values intraoperatively. This increase did not correspond to decreases in either mean arterial pressure (MAP) or CI, but did appear to correlate with decreased intraoperative Vo2. Postoperatively, lactate levels remained elevated, and this elevation appeared to correlate with an estimation of intraoperative oxygen deficit. CI and Vo2 were increased postoperatively; the data support the hypothesis that these postoperative increases in CI and Vo2 represent physiological compensations for intraoperative oxygen deficits. Clinically, determinations of lactate values may prove useful in titrating postoperative therapy to support needed physiological compensations.</abstract><cop>United States</cop><pub>Williams & Wilkins</pub><pmid>7060384</pmid><doi>10.1097/00003246-198202000-00005</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0090-3493 |
| ispartof | Critical care medicine, 1982-02, Vol.10 (2), p.96-99 |
| issn | 0090-3493 1530-0293 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73998675 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Aged Blood Pressure Cardiac Output Female Humans Intraoperative Period Lactates - blood Male Middle Aged Oxygen Consumption Postoperative Care Postoperative Period |
| title | Sequential perioperative lactate determination. Physiological and clinical implications |
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