Betazole-induced GIP secretion is not mediated by gastric HCl

Betazole, a pyrazole analogue of histamine, as well as pentagastrin and HCl stimulate GIP secretion. We have asked the question as to whether betazole acts directly or via the production of HCl. Eight normal subjects and 4 patients with achlorhydria secondary to pernicious anemia were given betazole...

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Veröffentlicht in:	Metabolism, clinical and experimental clinical and experimental, 1982-04, Vol.31 (4), p.380-382
Hauptverfasser:	Spitz, I.M., Novis, B.H., Ebert, R., Trestian, S., LeRoith, D., Creutzfeldt, W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Achlorhydria - blood Adolescent Adult Anemia, Pernicious - complications Betazole Blood Pressure - drug effects Cimetidine - pharmacology Gastric Acid - metabolism Gastric Inhibitory Polypeptide - blood Gastric Inhibitory Polypeptide - metabolism Gastritis, Atrophic - complications Gastrointestinal Hormones - metabolism Humans Male Middle Aged Pyrazoles Time Factors
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