Specificity of the cyclic GMP-binding activity and of a cyclic GMP-dependent cyclic GMP phosphodiesterase in Dictyostelium discoideum

The nucleotide specificity of the cyclic GMP-binding activity in a homogenate of Dictyostelium discoideum was determined by competition of cyclic GMP derivatives with [8-3H]-cyclic GMP for the binding sites. The results indicate that cyclic GMP is bound to the binding proteins by hydrogen bonds at N...

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Veröffentlicht in:	Molecular and cellular endocrinology 1982-02, Vol.25 (2), p.171-182
Hauptverfasser:	van Haastert, P J, van Walsum, H, van der Meer, R C, Bulgakov, R, Konijn, T M
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-GMP Phosphodiesterases - metabolism Binding Sites Carrier Proteins - metabolism Cyclic GMP - analogs & derivatives Cyclic GMP - metabolism Dictyostelium - metabolism Dictyostelium discoideum Enzyme Activation Enzyme Inhibitors Substrate Specificity
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