Increased Collateral Arterial and Venous Endothelial Cell Turnover After Renal Artery Stenosis in the Dog
Renal artery stenosis was induced in dogs and collateral arterial formation assessed by serial angiography and histology. Endothelial cell turnover was estimated by radioautography in five normal and five collateral-forming kidneys 18-39 days following stenosis with tritiated thymidine. Normal arter...
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| Veröffentlicht in: | Investigative radiology 1978-03, Vol.13 (2), p.143-149 |
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| container_title | Investigative radiology |
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| creator | COWAN, DOUGLAS F HOLLENBERG, NORMAN K CONNELLY, CAROLYN M WILLIAMS, DEBORAH H ABRAMS, HERBERT L |
| description | Renal artery stenosis was induced in dogs and collateral arterial formation assessed by serial angiography and histology. Endothelial cell turnover was estimated by radioautography in five normal and five collateral-forming kidneys 18-39 days following stenosis with tritiated thymidine. Normal arterial endothelial labeling was 0.1% with a highly significant (p |
| doi_str_mv | 10.1097/00004424-197803000-00008 |
| format | Article |
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Endothelial cell turnover was estimated by radioautography in five normal and five collateral-forming kidneys 18-39 days following stenosis with tritiated thymidine. Normal arterial endothelial labeling was 0.1% with a highly significant (p<0.0005), 55-fold increase in endothelial labeling in arterial collateral vessels. A smaller but statistically significant increase in the labeling index was also found in endothelial cells of the renal vein, from a normal of 0.065% to 0.4% (p<0.005). An excellent correlation was found between endothelial cell labeling in small arteries and the renal veins (r=0.97; p<0.01). A marked increase in epithelial cell labeling of the ureters draining the stenotic kidneys was also evident (p<0.005). Thus, collateral vessel development is characterized by active DNA synthesis in cellular elements, and a humoral factor is implicated in the vascular response.</description><identifier>ISSN: 0020-9996</identifier><identifier>EISSN: 1536-0210</identifier><identifier>DOI: 10.1097/00004424-197803000-00008</identifier><identifier>PMID: 659085</identifier><language>eng</language><publisher>United States: Lippincott-Raven Publishers</publisher><subject>Angiography ; Animals ; Cell Division ; Collateral Circulation ; DNA - biosynthesis ; Dogs ; Renal Artery - diagnostic imaging ; Renal Artery - physiopathology ; Renal Artery Obstruction - diagnostic imaging ; Renal Artery Obstruction - physiopathology ; Renal Veins - diagnostic imaging ; Renal Veins - physiopathology ; Space life sciences</subject><ispartof>Investigative radiology, 1978-03, Vol.13 (2), p.143-149</ispartof><rights>Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3548-4948a354ce132e9345698efaed62597776c752584a02326c86f562792874e6533</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/659085$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>COWAN, DOUGLAS F</creatorcontrib><creatorcontrib>HOLLENBERG, NORMAN K</creatorcontrib><creatorcontrib>CONNELLY, CAROLYN M</creatorcontrib><creatorcontrib>WILLIAMS, DEBORAH H</creatorcontrib><creatorcontrib>ABRAMS, HERBERT L</creatorcontrib><title>Increased Collateral Arterial and Venous Endothelial Cell Turnover After Renal Artery Stenosis in the Dog</title><title>Investigative radiology</title><addtitle>Invest Radiol</addtitle><description>Renal artery stenosis was induced in dogs and collateral arterial formation assessed by serial angiography and histology. Endothelial cell turnover was estimated by radioautography in five normal and five collateral-forming kidneys 18-39 days following stenosis with tritiated thymidine. Normal arterial endothelial labeling was 0.1% with a highly significant (p<0.0005), 55-fold increase in endothelial labeling in arterial collateral vessels. A smaller but statistically significant increase in the labeling index was also found in endothelial cells of the renal vein, from a normal of 0.065% to 0.4% (p<0.005). An excellent correlation was found between endothelial cell labeling in small arteries and the renal veins (r=0.97; p<0.01). A marked increase in epithelial cell labeling of the ureters draining the stenotic kidneys was also evident (p<0.005). Thus, collateral vessel development is characterized by active DNA synthesis in cellular elements, and a humoral factor is implicated in the vascular response.</description><subject>Angiography</subject><subject>Animals</subject><subject>Cell Division</subject><subject>Collateral Circulation</subject><subject>DNA - biosynthesis</subject><subject>Dogs</subject><subject>Renal Artery - diagnostic imaging</subject><subject>Renal Artery - physiopathology</subject><subject>Renal Artery Obstruction - diagnostic imaging</subject><subject>Renal Artery Obstruction - physiopathology</subject><subject>Renal Veins - diagnostic imaging</subject><subject>Renal Veins - physiopathology</subject><subject>Space life sciences</subject><issn>0020-9996</issn><issn>1536-0210</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UclOwzAQtRBbWf6Ag0_cAt6XY1VWCQmJ7WqZZEIDblLsBMTf49Llhi8zfvPeeOYZIUzJGSVWn5N8hGCioFYbwvOtWEBmC42o5KogjJJtNCKEkcJaq_bRQUrvmcE04XtoV0lLjByh5rYtI_gEFZ50Ifgeog94HHNscuLbCr9A2w0JX7ZV108hLOAJhICfhth2XxDxuM5s_ADtWvmDH_ssSk3CTYuzCF90b0dop_YhwfEqHqLnq8unyU1xd399OxnfFSWXwhTCCuNzVgLlDCwXUlkDtYdKMWm11qrUkkkjPGGcqdKoWiqmLTNagJKcH6LTZd957D4HSL2bNanMA_sW8h5Oc2uppSQTzZJYxi6lCLWbx2bm44-jxC1MdmuT3cbkP8hk6cnqjeF1BtVGuHQ1l8Wy_N2FbEf6CMM3RDcFH_qp--_r-C__m4VD</recordid><startdate>197803</startdate><enddate>197803</enddate><creator>COWAN, DOUGLAS F</creator><creator>HOLLENBERG, NORMAN K</creator><creator>CONNELLY, CAROLYN M</creator><creator>WILLIAMS, DEBORAH H</creator><creator>ABRAMS, HERBERT L</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197803</creationdate><title>Increased Collateral Arterial and Venous Endothelial Cell Turnover After Renal Artery Stenosis in the Dog</title><author>COWAN, DOUGLAS F ; HOLLENBERG, NORMAN K ; CONNELLY, CAROLYN M ; WILLIAMS, DEBORAH H ; ABRAMS, HERBERT L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3548-4948a354ce132e9345698efaed62597776c752584a02326c86f562792874e6533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Angiography</topic><topic>Animals</topic><topic>Cell Division</topic><topic>Collateral Circulation</topic><topic>DNA - biosynthesis</topic><topic>Dogs</topic><topic>Renal Artery - diagnostic imaging</topic><topic>Renal Artery - physiopathology</topic><topic>Renal Artery Obstruction - diagnostic imaging</topic><topic>Renal Artery Obstruction - physiopathology</topic><topic>Renal Veins - diagnostic imaging</topic><topic>Renal Veins - physiopathology</topic><topic>Space life sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>COWAN, DOUGLAS F</creatorcontrib><creatorcontrib>HOLLENBERG, NORMAN K</creatorcontrib><creatorcontrib>CONNELLY, CAROLYN M</creatorcontrib><creatorcontrib>WILLIAMS, DEBORAH H</creatorcontrib><creatorcontrib>ABRAMS, HERBERT L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>COWAN, DOUGLAS F</au><au>HOLLENBERG, NORMAN K</au><au>CONNELLY, CAROLYN M</au><au>WILLIAMS, DEBORAH H</au><au>ABRAMS, HERBERT L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased Collateral Arterial and Venous Endothelial Cell Turnover After Renal Artery Stenosis in the Dog</atitle><jtitle>Investigative radiology</jtitle><addtitle>Invest Radiol</addtitle><date>1978-03</date><risdate>1978</risdate><volume>13</volume><issue>2</issue><spage>143</spage><epage>149</epage><pages>143-149</pages><issn>0020-9996</issn><eissn>1536-0210</eissn><abstract>Renal artery stenosis was induced in dogs and collateral arterial formation assessed by serial angiography and histology. Endothelial cell turnover was estimated by radioautography in five normal and five collateral-forming kidneys 18-39 days following stenosis with tritiated thymidine. Normal arterial endothelial labeling was 0.1% with a highly significant (p<0.0005), 55-fold increase in endothelial labeling in arterial collateral vessels. A smaller but statistically significant increase in the labeling index was also found in endothelial cells of the renal vein, from a normal of 0.065% to 0.4% (p<0.005). An excellent correlation was found between endothelial cell labeling in small arteries and the renal veins (r=0.97; p<0.01). A marked increase in epithelial cell labeling of the ureters draining the stenotic kidneys was also evident (p<0.005). Thus, collateral vessel development is characterized by active DNA synthesis in cellular elements, and a humoral factor is implicated in the vascular response.</abstract><cop>United States</cop><pub>Lippincott-Raven Publishers</pub><pmid>659085</pmid><doi>10.1097/00004424-197803000-00008</doi><tpages>7</tpages></addata></record> |
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| ispartof | Investigative radiology, 1978-03, Vol.13 (2), p.143-149 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Angiography Animals Cell Division Collateral Circulation DNA - biosynthesis Dogs Renal Artery - diagnostic imaging Renal Artery - physiopathology Renal Artery Obstruction - diagnostic imaging Renal Artery Obstruction - physiopathology Renal Veins - diagnostic imaging Renal Veins - physiopathology Space life sciences |
| title | Increased Collateral Arterial and Venous Endothelial Cell Turnover After Renal Artery Stenosis in the Dog |
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