Toward a biochemical classification of depressive disorders, V: Heterogeneity of unipolar depressions
The authors found that the mean urinary level of 3-methoxy-4- hydroxyphenylglycol (MHPG) was significantly lower in 20 patients with bipolar manic-depressive or schizoaffective depressions than in either 50 patients with unipolar depressions or 26 age- and sex-matched control subjects. In contrast,...
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| Veröffentlicht in: | The American journal of psychiatry 1982-04, Vol.139 (4), p.471-475 |
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| container_issue | 4 |
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| container_title | The American journal of psychiatry |
| container_volume | 139 |
| creator | Schatzberg, A F Orsulak, P J Rosenbaum, A H Maruta, T Kruger, E R Cole, J O Schildkraut, J J |
| description | The authors found that the mean urinary level of 3-methoxy-4-
hydroxyphenylglycol (MHPG) was significantly lower in 20 patients with
bipolar manic-depressive or schizoaffective depressions than in either 50
patients with unipolar depressions or 26 age- and sex-matched control
subjects. In contrast, the mean MHPG levels in the total group of patients
with unipolar depressions and in any subgroup defined by Research
Diagnostic Criteria (RDC) were not significantly different from control
values. However, examination of the distribution of urinary MHPG levels in
patients with unipolar depressions in relation to other recent findings by
the authors' collaborative research group suggested the existence of at
least three biochemical subtypes of unipolar depressions that may, in part,
be differentiated on the basis of urinary MHPG levels. |
| doi_str_mv | 10.1176/ajp.139.4.471 |
| format | Article |
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hydroxyphenylglycol (MHPG) was significantly lower in 20 patients with
bipolar manic-depressive or schizoaffective depressions than in either 50
patients with unipolar depressions or 26 age- and sex-matched control
subjects. In contrast, the mean MHPG levels in the total group of patients
with unipolar depressions and in any subgroup defined by Research
Diagnostic Criteria (RDC) were not significantly different from control
values. However, examination of the distribution of urinary MHPG levels in
patients with unipolar depressions in relation to other recent findings by
the authors' collaborative research group suggested the existence of at
least three biochemical subtypes of unipolar depressions that may, in part,
be differentiated on the basis of urinary MHPG levels.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/ajp.139.4.471</identifier><identifier>PMID: 7065292</identifier><language>eng</language><publisher>United States: American Psychiatric Publishing</publisher><subject>Adult ; Bipolar Disorder - urine ; Depressive Disorder - classification ; Depressive Disorder - urine ; Glycols - urine ; Humans ; Methoxyhydroxyphenylglycol - urine ; Psychotic Disorders - urine ; Schizophrenia - urine ; Vanilmandelic Acid - urine</subject><ispartof>The American journal of psychiatry, 1982-04, Vol.139 (4), p.471-475</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a266t-ccac355da4d98cdc1ebe32d43695ee8f8ec81aeb39c48884823e7470e0e38e843</citedby><cites>FETCH-LOGICAL-a266t-ccac355da4d98cdc1ebe32d43695ee8f8ec81aeb39c48884823e7470e0e38e843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/ajp.139.4.471$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/ajp.139.4.471$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,776,780,2846,21610,27848,27903,27904,77537,77538</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7065292$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schatzberg, A F</creatorcontrib><creatorcontrib>Orsulak, P J</creatorcontrib><creatorcontrib>Rosenbaum, A H</creatorcontrib><creatorcontrib>Maruta, T</creatorcontrib><creatorcontrib>Kruger, E R</creatorcontrib><creatorcontrib>Cole, J O</creatorcontrib><creatorcontrib>Schildkraut, J J</creatorcontrib><title>Toward a biochemical classification of depressive disorders, V: Heterogeneity of unipolar depressions</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>The authors found that the mean urinary level of 3-methoxy-4-
hydroxyphenylglycol (MHPG) was significantly lower in 20 patients with
bipolar manic-depressive or schizoaffective depressions than in either 50
patients with unipolar depressions or 26 age- and sex-matched control
subjects. In contrast, the mean MHPG levels in the total group of patients
with unipolar depressions and in any subgroup defined by Research
Diagnostic Criteria (RDC) were not significantly different from control
values. However, examination of the distribution of urinary MHPG levels in
patients with unipolar depressions in relation to other recent findings by
the authors' collaborative research group suggested the existence of at
least three biochemical subtypes of unipolar depressions that may, in part,
be differentiated on the basis of urinary MHPG levels.</description><subject>Adult</subject><subject>Bipolar Disorder - urine</subject><subject>Depressive Disorder - classification</subject><subject>Depressive Disorder - urine</subject><subject>Glycols - urine</subject><subject>Humans</subject><subject>Methoxyhydroxyphenylglycol - urine</subject><subject>Psychotic Disorders - urine</subject><subject>Schizophrenia - urine</subject><subject>Vanilmandelic Acid - urine</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><recordid>eNptkMtLxDAQxoMouj6OHoWC4EHsmlebxJuILxC8qHgL2WSqWbpNTVrF_97ILiLiaV6_-Wb4ENoneEqIqE_NvJ8SpqZ8ygVZQxNSsaoUlMp1NMEY01JV7HkLbac0zyVmgm6iTYHriio6QfAQPkx0hSlmPthXWHhr2sK2JiXf5HzwoStCUzjoI-TeOxTOpxAdxHRSPJ0VNzBADC_QgR8-v8mx831oTfxZCV3aRRuNaRPsreIOery6fLi4Ke_ur28vzu9KQ-t6KK01llWVM9wpaZ0lMANGHWe1qgBkI8FKYmDGlOVSSi4pA8EFBgxMguRsBx0tdfsY3kZIg174ZKFtTQdhTFowJRkWKoOHf8B5GGOXf9OEEVxjQhTJVLmkbAwpRWh0H_3CxE9NsP42X2fz84LSXGfzM3-wUh1nC3A_9MrtPD9ezk3f-18X_xX7At0Njv0</recordid><startdate>198204</startdate><enddate>198204</enddate><creator>Schatzberg, A F</creator><creator>Orsulak, P J</creator><creator>Rosenbaum, A H</creator><creator>Maruta, T</creator><creator>Kruger, E R</creator><creator>Cole, J O</creator><creator>Schildkraut, J J</creator><general>American Psychiatric Publishing</general><general>American Psychiatric Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>HAWNG</scope><scope>HBMBR</scope><scope>IBDFT</scope><scope>K30</scope><scope>PAAUG</scope><scope>PAWHS</scope><scope>PAWZZ</scope><scope>PAXOH</scope><scope>PBHAV</scope><scope>PBQSW</scope><scope>PBYQZ</scope><scope>PCIWU</scope><scope>PCMID</scope><scope>PCZJX</scope><scope>PDGRG</scope><scope>PDWWI</scope><scope>PETMR</scope><scope>PFVGT</scope><scope>PGXDX</scope><scope>PIHIL</scope><scope>PISVA</scope><scope>PJCTQ</scope><scope>PJTMS</scope><scope>PLCHJ</scope><scope>PMHAD</scope><scope>PNQDJ</scope><scope>POUND</scope><scope>PPLAD</scope><scope>PQAPC</scope><scope>PQCAN</scope><scope>PQCMW</scope><scope>PQEME</scope><scope>PQHKH</scope><scope>PQMID</scope><scope>PQNCT</scope><scope>PQNET</scope><scope>PQSCT</scope><scope>PQSET</scope><scope>PSVJG</scope><scope>PVMQY</scope><scope>PZGFC</scope><scope>7X8</scope></search><sort><creationdate>198204</creationdate><title>Toward a biochemical classification of depressive disorders, V: Heterogeneity of unipolar depressions</title><author>Schatzberg, A F ; Orsulak, P J ; Rosenbaum, A H ; Maruta, T ; Kruger, E R ; Cole, J O ; Schildkraut, J J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a266t-ccac355da4d98cdc1ebe32d43695ee8f8ec81aeb39c48884823e7470e0e38e843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Adult</topic><topic>Bipolar Disorder - 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hydroxyphenylglycol (MHPG) was significantly lower in 20 patients with
bipolar manic-depressive or schizoaffective depressions than in either 50
patients with unipolar depressions or 26 age- and sex-matched control
subjects. In contrast, the mean MHPG levels in the total group of patients
with unipolar depressions and in any subgroup defined by Research
Diagnostic Criteria (RDC) were not significantly different from control
values. However, examination of the distribution of urinary MHPG levels in
patients with unipolar depressions in relation to other recent findings by
the authors' collaborative research group suggested the existence of at
least three biochemical subtypes of unipolar depressions that may, in part,
be differentiated on the basis of urinary MHPG levels.</abstract><cop>United States</cop><pub>American Psychiatric Publishing</pub><pmid>7065292</pmid><doi>10.1176/ajp.139.4.471</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | The American journal of psychiatry, 1982-04, Vol.139 (4), p.471-475 |
| issn | 0002-953X 1535-7228 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73983079 |
| source | MEDLINE; Psychiatry Legacy Collection Online Journals 1844-1996; Periodicals Index Online |
| subjects | Adult Bipolar Disorder - urine Depressive Disorder - classification Depressive Disorder - urine Glycols - urine Humans Methoxyhydroxyphenylglycol - urine Psychotic Disorders - urine Schizophrenia - urine Vanilmandelic Acid - urine |
| title | Toward a biochemical classification of depressive disorders, V: Heterogeneity of unipolar depressions |
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