Conduction velocity in nerve fibres with axonal atrophy due to chronic β,β′-iminodiproprionitrile (IDPN)
Serial measurements of maximal motor nerve conduction velocity and muscle action potential amplitude were made on 2 groups of rats for up to 16 months. Group A received 0.05% IDPN in drinking water. Group B received a single injection of 1 g/kg i.p. In the chronically intoxicated animals conduction...
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| Veröffentlicht in: | Journal of the neurological sciences 1982-01, Vol.53 (2), p.159-167 |
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| creator | Höfinger, Eva Le Quesne, Pamela M. Gajree, Tarlok |
| description | Serial measurements of maximal motor nerve conduction velocity and muscle action potential amplitude were made on 2 groups of rats for up to 16 months. Group A received 0.05% IDPN in drinking water. Group B received a single injection of 1 g/kg i.p. In the chronically intoxicated animals conduction velocity progressively fell compared with control animals, from a reduction of 7% after 4 months to 22% after 13 months. There was no reduction in muscle action potential amplitude. Marked axonal atrophy was found in distal ventral roots. Many grossly dilated axons were present in proximal ventral roots.
In the animals which received a single dose of IDPN no electrophysiological changes were found. A few dilated axons were present in proximal ventral roots. but changes were less severe than in Group A. No distal axonal atrophy was demonstrated. |
| doi_str_mv | 10.1016/0022-510X(82)90002-8 |
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In the animals which received a single dose of IDPN no electrophysiological changes were found. A few dilated axons were present in proximal ventral roots. but changes were less severe than in Group A. No distal axonal atrophy was demonstrated.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/0022-510X(82)90002-8</identifier><identifier>PMID: 7057208</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Axons - drug effects ; Dose-Response Relationship, Drug ; Evoked Potentials - drug effects ; Hindlimb - innervation ; Motor Neurons - drug effects ; Muscles - innervation ; Nerve Degeneration - drug effects ; Nerve Fibers - drug effects ; Nerve Fibers, Myelinated - drug effects ; Neural Conduction - drug effects ; Nitriles - pharmacology ; Rats ; Rats, Inbred Strains ; Spinal Cord - drug effects ; Spinal Nerve Roots - drug effects ; Tibial Nerve - drug effects</subject><ispartof>Journal of the neurological sciences, 1982-01, Vol.53 (2), p.159-167</ispartof><rights>1982</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-c2e6ef3284608a793f5fe3b5e5c27dd048e3ccae74bc73fb81657417f386069b3</citedby><cites>FETCH-LOGICAL-c388t-c2e6ef3284608a793f5fe3b5e5c27dd048e3ccae74bc73fb81657417f386069b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0022-510X(82)90002-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7057208$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Höfinger, Eva</creatorcontrib><creatorcontrib>Le Quesne, Pamela M.</creatorcontrib><creatorcontrib>Gajree, Tarlok</creatorcontrib><title>Conduction velocity in nerve fibres with axonal atrophy due to chronic β,β′-iminodiproprionitrile (IDPN)</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>Serial measurements of maximal motor nerve conduction velocity and muscle action potential amplitude were made on 2 groups of rats for up to 16 months. Group A received 0.05% IDPN in drinking water. Group B received a single injection of 1 g/kg i.p. In the chronically intoxicated animals conduction velocity progressively fell compared with control animals, from a reduction of 7% after 4 months to 22% after 13 months. There was no reduction in muscle action potential amplitude. Marked axonal atrophy was found in distal ventral roots. Many grossly dilated axons were present in proximal ventral roots.
In the animals which received a single dose of IDPN no electrophysiological changes were found. A few dilated axons were present in proximal ventral roots. but changes were less severe than in Group A. No distal axonal atrophy was demonstrated.</description><subject>Animals</subject><subject>Axons - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Evoked Potentials - drug effects</subject><subject>Hindlimb - innervation</subject><subject>Motor Neurons - drug effects</subject><subject>Muscles - innervation</subject><subject>Nerve Degeneration - drug effects</subject><subject>Nerve Fibers - drug effects</subject><subject>Nerve Fibers, Myelinated - drug effects</subject><subject>Neural Conduction - drug effects</subject><subject>Nitriles - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Spinal Cord - drug effects</subject><subject>Spinal Nerve Roots - drug effects</subject><subject>Tibial Nerve - drug effects</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxi0EareFNwDJJ9RKDfhPEk8uSGjbQqWqcACJm5U4E62rrF1sZ2FvfaZ9kD5EnwQvu-oRTqPR_OabmW8Iec3ZO854_Z4xIYqKsx8nIE4bltMCnpEZBwVFBSCfk9kTckiOYrzNTA3QHJADxSolGMzIOPeun0yy3tEVjt7YtKbWUYdhhXSwXcBIf9m0oO1v79qRtin4u8Wa9hPS5KlZBO-soQ-bs4fN4_2msEvrfG_vMhWyqE3BjkhPrs6_3py-JC-Gdoz4ah-PyffLi2_zz8X1l09X84_XhZEAqTACaxykgLJm0KpGDtWAsquwMkL1PSsBpTEtqrIzSg4d8LpSJVeDhJrVTSePydudbt7i54Qx6aWNBsexdeinqJVsQEjF_gvyqmwkr2UGyx1ogo8x4KDzdcs2rDVnevsNvbVab63WIPTfb2jIbW_2-lO3xP6paW9_rn_Y1TG7sbIYdDQWncHeBjRJ997-e8AfB6-clA</recordid><startdate>19820101</startdate><enddate>19820101</enddate><creator>Höfinger, Eva</creator><creator>Le Quesne, Pamela M.</creator><creator>Gajree, Tarlok</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19820101</creationdate><title>Conduction velocity in nerve fibres with axonal atrophy due to chronic β,β′-iminodiproprionitrile (IDPN)</title><author>Höfinger, Eva ; Le Quesne, Pamela M. ; Gajree, Tarlok</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-c2e6ef3284608a793f5fe3b5e5c27dd048e3ccae74bc73fb81657417f386069b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Animals</topic><topic>Axons - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Evoked Potentials - drug effects</topic><topic>Hindlimb - innervation</topic><topic>Motor Neurons - drug effects</topic><topic>Muscles - innervation</topic><topic>Nerve Degeneration - drug effects</topic><topic>Nerve Fibers - drug effects</topic><topic>Nerve Fibers, Myelinated - drug effects</topic><topic>Neural Conduction - drug effects</topic><topic>Nitriles - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Spinal Cord - drug effects</topic><topic>Spinal Nerve Roots - drug effects</topic><topic>Tibial Nerve - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Höfinger, Eva</creatorcontrib><creatorcontrib>Le Quesne, Pamela M.</creatorcontrib><creatorcontrib>Gajree, Tarlok</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Höfinger, Eva</au><au>Le Quesne, Pamela M.</au><au>Gajree, Tarlok</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Conduction velocity in nerve fibres with axonal atrophy due to chronic β,β′-iminodiproprionitrile (IDPN)</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>1982-01-01</date><risdate>1982</risdate><volume>53</volume><issue>2</issue><spage>159</spage><epage>167</epage><pages>159-167</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><abstract>Serial measurements of maximal motor nerve conduction velocity and muscle action potential amplitude were made on 2 groups of rats for up to 16 months. Group A received 0.05% IDPN in drinking water. Group B received a single injection of 1 g/kg i.p. In the chronically intoxicated animals conduction velocity progressively fell compared with control animals, from a reduction of 7% after 4 months to 22% after 13 months. There was no reduction in muscle action potential amplitude. Marked axonal atrophy was found in distal ventral roots. Many grossly dilated axons were present in proximal ventral roots.
In the animals which received a single dose of IDPN no electrophysiological changes were found. A few dilated axons were present in proximal ventral roots. but changes were less severe than in Group A. No distal axonal atrophy was demonstrated.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>7057208</pmid><doi>10.1016/0022-510X(82)90002-8</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of the neurological sciences, 1982-01, Vol.53 (2), p.159-167 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Axons - drug effects Dose-Response Relationship, Drug Evoked Potentials - drug effects Hindlimb - innervation Motor Neurons - drug effects Muscles - innervation Nerve Degeneration - drug effects Nerve Fibers - drug effects Nerve Fibers, Myelinated - drug effects Neural Conduction - drug effects Nitriles - pharmacology Rats Rats, Inbred Strains Spinal Cord - drug effects Spinal Nerve Roots - drug effects Tibial Nerve - drug effects |
| title | Conduction velocity in nerve fibres with axonal atrophy due to chronic β,β′-iminodiproprionitrile (IDPN) |
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