Effects of steroid sex hormones and adriamycin on human bladder cancer cells in culture

The effects of steroid sex hormones on the established cell lines derived from human urinary bladder cancer, T24, and from human transitional cell cancer of the urinary tract, 253J, were examined using the colony formation method. Of the seven kinds of steroid hormones tested, estradiol-17 beta was...

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Veröffentlicht in:	Acta medica Okayama 1982-02, Vol.36 (1), p.61-66
Hauptverfasser:	Yoshimoto, J, Matsumura, Y, Tanahashi, T, Ohmori, H, Tokiwa, T, Sato, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Carcinoma, Transitional Cell - drug therapy Carcinoma, Transitional Cell - pathology Cell Division - drug effects Cell Line Doxorubicin - administration & dosage Drug Therapy, Combination Estradiol - administration & dosage Female Gonadal Steroid Hormones - administration & dosage Humans Male Middle Aged Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - pathology Urologic Neoplasms - drug therapy Urologic Neoplasms - pathology
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Zusammenfassung:	The effects of steroid sex hormones on the established cell lines derived from human urinary bladder cancer, T24, and from human transitional cell cancer of the urinary tract, 253J, were examined using the colony formation method. Of the seven kinds of steroid hormones tested, estradiol-17 beta was intensively cytotoxic for both cells. The cytotoxic effect was depended on the dose and time of treatment. The combined effect of Adriamycin and estradiol-17 beta on T24 cells could be recognized at low concentrations of Adriamycin (less than or equal to 10(-3) micrograms/ml) after exposure for 24 h.
ISSN:	0386-300X