Interaction of avermectins with [ 3H]β-carboline-3-carboxylate ethyl ester and [ 3H]Diazepam binding sites in rat brain cortical membranes

The binding of [ 3H]β-carboline-3-carboxylate ethyl ester ([ 3H]β-CCE), a ligand for the benzodiazepine receptor in the mammalian CNS, to rat cortical membranes, is enhanced by avermectin B 1a and its therapeutic formulation, Ivermectin. In contrast to the effects of the avermectins on [ 3H]diazepam...

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Veröffentlicht in:	European journal of pharmacology 1982-02, Vol.77 (4), p.307-312
Hauptverfasser:	Williams, Michael, Risley, Edwin A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Avermectin Benzodiazepines Binding Sites - drug effects Carbolines - metabolism Cell Membrane - metabolism Cerebral Cortex - metabolism Diazepam - metabolism Indoles - metabolism Ivermectin - analogs & derivatives Lactones - pharmacology Rats Receptors, Drug - metabolism Receptors, GABA-A β-Carbolines
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