Dehydroepiandrosterone and androstenediol in human primary breast tumours

Dehydroepiandrosterone (DHA) and 5-androstene- 3β,- 17β-diol have been measured in a series of primary human breast tumours. All the tissues contained significant quantities of DHA and there was a negative correlation of these values with the age of the patient. Only just over one half of the tumour...

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Veröffentlicht in:	European journal of cancer 1978-05, Vol.14 (5), p.549-553
Hauptverfasser:	Maynard, P.V., Bird, Margaret, Basu, P.K., Shields, R., Griffiths, K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aged Androstenediols - analysis Breast Neoplasms - analysis Dehydroepiandrosterone - analysis Female Humans Middle Aged Receptors, Estrogen - analysis
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container_end_page	553
container_issue	5
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container_title	European journal of cancer
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creator	Maynard, P.V. Bird, Margaret Basu, P.K. Shields, R. Griffiths, K.
description	Dehydroepiandrosterone (DHA) and 5-androstene- 3β,- 17β-diol have been measured in a series of primary human breast tumours. All the tissues contained significant quantities of DHA and there was a negative correlation of these values with the age of the patient. Only just over one half of the tumours contained detectable levels of androstenediol but there was an over-all correlation of this steroid with the DHA, although concentrations of DHA were generally much greater. No relationship between the steroid content of the tumour and the oestrogen receptor levels was established although receptor was not measurable in the relatively small number of tumours which contained high levels of either steroid. Quantities of endogenous C 19 -steroids would seem to be high enough to exert some influence on the activity of the oestrogen receptor in vivo.
doi_str_mv	10.1016/0014-2964(78)90259-1
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All the tissues contained significant quantities of DHA and there was a negative correlation of these values with the age of the patient. Only just over one half of the tumours contained detectable levels of androstenediol but there was an over-all correlation of this steroid with the DHA, although concentrations of DHA were generally much greater. No relationship between the steroid content of the tumour and the oestrogen receptor levels was established although receptor was not measurable in the relatively small number of tumours which contained high levels of either steroid. Quantities of endogenous C 19 -steroids would seem to be high enough to exert some influence on the activity of the oestrogen receptor in vivo.</description><identifier>ISSN: 0014-2964</identifier><identifier>DOI: 10.1016/0014-2964(78)90259-1</identifier><identifier>PMID: 148361</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Age Factors ; Aged ; Androstenediols - analysis ; Breast Neoplasms - analysis ; Dehydroepiandrosterone - analysis ; Female ; Humans ; Middle Aged ; Receptors, Estrogen - analysis</subject><ispartof>European journal of cancer, 1978-05, Vol.14 (5), p.549-553</ispartof><rights>1978</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-c2e61b36f1e632f2587227e97fd4e25e999fb1c4983a76b092f3be41ea8506d83</citedby><cites>FETCH-LOGICAL-c356t-c2e61b36f1e632f2587227e97fd4e25e999fb1c4983a76b092f3be41ea8506d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/148361$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maynard, P.V.</creatorcontrib><creatorcontrib>Bird, Margaret</creatorcontrib><creatorcontrib>Basu, P.K.</creatorcontrib><creatorcontrib>Shields, R.</creatorcontrib><creatorcontrib>Griffiths, K.</creatorcontrib><title>Dehydroepiandrosterone and androstenediol in human primary breast tumours</title><title>European journal of cancer</title><addtitle>Eur J Cancer</addtitle><description>Dehydroepiandrosterone (DHA) and 5-androstene- 3β,- 17β-diol have been measured in a series of primary human breast tumours. All the tissues contained significant quantities of DHA and there was a negative correlation of these values with the age of the patient. Only just over one half of the tumours contained detectable levels of androstenediol but there was an over-all correlation of this steroid with the DHA, although concentrations of DHA were generally much greater. No relationship between the steroid content of the tumour and the oestrogen receptor levels was established although receptor was not measurable in the relatively small number of tumours which contained high levels of either steroid. Quantities of endogenous C 19 -steroids would seem to be high enough to exert some influence on the activity of the oestrogen receptor in vivo.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Androstenediols - analysis</subject><subject>Breast Neoplasms - analysis</subject><subject>Dehydroepiandrosterone - analysis</subject><subject>Female</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Receptors, Estrogen - analysis</subject><issn>0014-2964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDlPxDAQhV1wL_yDLVIhKAK-4qNBQsu10ko0UFuOM9Ea5VjsBGn_Pd4D6KhGM2_e08yH0JTgG4KJuMWY8Jxqwa-kutaYFjonB-j0d3yCzmL8wJgqXtBjdES4YoKcovkDLNdV6GHlbZdqHCD0HWSpyX4GHVS-bzLfZcuxtV22Cr61YZ2VAWwcsmFs-zHEc3RY2ybCxb5O0PvT49vsJV-8Ps9n94vcsUIMuaMgSMlETUAwWtNCSUolaFlXHGgBWuu6JI5rxawUJda0ZiVwAlYVWFSKTdDlLncV-s8R4mBaHx00je2gH6ORTMuCUJoW-W7RpS9igNrsDzcEmw00s6FjNnSMVGYLzZBkm-7zx7KF6s-0JZbku50M6ccvD8FE56FziVEAN5iq9__nfwNIzH4t</recordid><startdate>197805</startdate><enddate>197805</enddate><creator>Maynard, P.V.</creator><creator>Bird, Margaret</creator><creator>Basu, P.K.</creator><creator>Shields, R.</creator><creator>Griffiths, K.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197805</creationdate><title>Dehydroepiandrosterone and androstenediol in human primary breast tumours</title><author>Maynard, P.V. ; Bird, Margaret ; Basu, P.K. ; Shields, R. ; Griffiths, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-c2e61b36f1e632f2587227e97fd4e25e999fb1c4983a76b092f3be41ea8506d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Androstenediols - analysis</topic><topic>Breast Neoplasms - analysis</topic><topic>Dehydroepiandrosterone - analysis</topic><topic>Female</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Receptors, Estrogen - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maynard, P.V.</creatorcontrib><creatorcontrib>Bird, Margaret</creatorcontrib><creatorcontrib>Basu, P.K.</creatorcontrib><creatorcontrib>Shields, R.</creatorcontrib><creatorcontrib>Griffiths, K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maynard, P.V.</au><au>Bird, Margaret</au><au>Basu, P.K.</au><au>Shields, R.</au><au>Griffiths, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dehydroepiandrosterone and androstenediol in human primary breast tumours</atitle><jtitle>European journal of cancer</jtitle><addtitle>Eur J Cancer</addtitle><date>1978-05</date><risdate>1978</risdate><volume>14</volume><issue>5</issue><spage>549</spage><epage>553</epage><pages>549-553</pages><issn>0014-2964</issn><abstract>Dehydroepiandrosterone (DHA) and 5-androstene- 3β,- 17β-diol have been measured in a series of primary human breast tumours. All the tissues contained significant quantities of DHA and there was a negative correlation of these values with the age of the patient. Only just over one half of the tumours contained detectable levels of androstenediol but there was an over-all correlation of this steroid with the DHA, although concentrations of DHA were generally much greater. No relationship between the steroid content of the tumour and the oestrogen receptor levels was established although receptor was not measurable in the relatively small number of tumours which contained high levels of either steroid. Quantities of endogenous C 19 -steroids would seem to be high enough to exert some influence on the activity of the oestrogen receptor in vivo.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>148361</pmid><doi>10.1016/0014-2964(78)90259-1</doi><tpages>5</tpages></addata></record>
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subjects	Adult Age Factors Aged Androstenediols - analysis Breast Neoplasms - analysis Dehydroepiandrosterone - analysis Female Humans Middle Aged Receptors, Estrogen - analysis
title	Dehydroepiandrosterone and androstenediol in human primary breast tumours
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