Do calcium-dependent ionic currents mediate ischemic ventricular fibrillation?

Calcium ions mediate the adverse effects of myocardial ischemia and have been implicated in the genesis of arrhythmias. Calcium influx blocking drugs protect against early ventricular arrhythmias during experimental coronary occlusion, and recent studies suggest that this effect is at least partly d...

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Veröffentlicht in:	The American journal of cardiology 1982-01, Vol.49 (3), p.606-612
Hauptverfasser:	Clusin, William T., Bristow, Michael R., Karagueuzian, Hrayr S., Katzung, Bertram G., Schroeder, John S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Coronary Circulation - drug effects Coronary Disease - metabolism Death, Sudden - etiology Diltiazem - pharmacology Heart Conduction System - drug effects Heart Conduction System - metabolism Heart Rate - drug effects Humans Ion Channels - drug effects Ion Channels - metabolism Membrane Potentials - drug effects Myocardium - metabolism Ventricular Fibrillation - metabolism Verapamil - pharmacology
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