Substrate and sequence specificity of a eukaryotic DNA methylase

In eukaryotic DNA, 50–90% of the dinucleotide sequence C-G is methylated. Most methylated sites are apparently placed at fixed locations in the genome and this methylation pattern is faithfully inherited from generation to generation 1 . Holliday and Pugh 2 and Riggs 3 have suggested that methyl moi...

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Veröffentlicht in:	Nature (London) 1982-02, Vol.295 (5850), p.620-622
Hauptverfasser:	Gruenbaum, Yosef, Cedar, Howard, Razin, Aharon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence DNA (Cytosine-5-)-Methyltransferases - metabolism Humanities and Social Sciences Kinetics L Cells (Cell Line) - enzymology letter Methyltransferases - metabolism Mice multidisciplinary Neoplasms, Experimental - enzymology Protein Biosynthesis Science Science (multidisciplinary) Substrate Specificity
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