Motor collateral sprouting through an end-to-side nerve repair
The outcome of end-to-side repair of peripheral nerves was investigated. The sciatic nerve in 10 male Sprague-Dawley rats was dissected to its tibioperoneal junction. The nerve to the medial gastrocnemius muscle, branching from the tibial nerve, was ligated at its origin and divided. Its distal end...
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| Veröffentlicht in: | The Journal of hand surgery (American ed.) 1998-09, Vol.23 (5), p.844-851 |
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| container_title | The Journal of hand surgery (American ed.) |
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| creator | Tham, Stephen K.Y. Morrison, Wayne A. |
| description | The outcome of end-to-side repair of peripheral nerves was investigated. The sciatic nerve in 10 male Sprague-Dawley rats was dissected to its tibioperoneal junction. The nerve to the medial gastrocnemius muscle, branching from the tibial nerve, was ligated at its origin and divided. Its distal end was sutured to an epineurial window on the side of the intact tibial nerve 1 cm distally. At 12 weeks, physiologic evaluation of the medial gastrocnemius muscle and analyses of histologic preparations of nerve and muscle were performed. The results showed that reinnervation successfully occurred in 8 rat media gastrocnemii. The mean weight of the reinnervated medial gastrocnemius was 73% of the contralateral normal muscle, the mean muscle fiber cross-sectional area of the reinnervated muscle was 72%, and the force of contraction was 60%. Analyses of histologic preparations revealed evidence of myelinated axons in the medial gastrocnemius nerve and no evidence of damage to axons of the donor tibial nerve. |
| doi_str_mv | 10.1016/S0363-5023(98)80161-5 |
| format | Article |
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The sciatic nerve in 10 male Sprague-Dawley rats was dissected to its tibioperoneal junction. The nerve to the medial gastrocnemius muscle, branching from the tibial nerve, was ligated at its origin and divided. Its distal end was sutured to an epineurial window on the side of the intact tibial nerve 1 cm distally. At 12 weeks, physiologic evaluation of the medial gastrocnemius muscle and analyses of histologic preparations of nerve and muscle were performed. The results showed that reinnervation successfully occurred in 8 rat media gastrocnemii. The mean weight of the reinnervated medial gastrocnemius was 73% of the contralateral normal muscle, the mean muscle fiber cross-sectional area of the reinnervated muscle was 72%, and the force of contraction was 60%. Analyses of histologic preparations revealed evidence of myelinated axons in the medial gastrocnemius nerve and no evidence of damage to axons of the donor tibial nerve.</description><identifier>ISSN: 0363-5023</identifier><identifier>EISSN: 1531-6564</identifier><identifier>DOI: 10.1016/S0363-5023(98)80161-5</identifier><identifier>PMID: 9763260</identifier><identifier>CODEN: JHSUDV</identifier><language>eng</language><publisher>New york, NY: Elsevier Inc</publisher><subject>Anastomosis, Surgical - methods ; Animals ; Biological and medical sciences ; Disease Models, Animal ; Male ; Medical sciences ; Motor Neurons - physiology ; Muscle Contraction - physiology ; Nerve Regeneration - physiology ; Psoas Muscles - innervation ; Psoas Muscles - pathology ; Rats ; Rats, Sprague-Dawley ; Reference Values ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology. Biomaterials. Equipments ; Tibial Nerve - pathology ; Tibial Nerve - physiology ; Tibial Nerve - surgery</subject><ispartof>The Journal of hand surgery (American ed.), 1998-09, Vol.23 (5), p.844-851</ispartof><rights>1998 The American Society for Surgery of the Hand.</rights><rights>1998 INIST-CNRS</rights><rights>Copyright Churchill Livingstone Inc., Medical Publishers Sep 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-581ad496feffdf3ff50a6ad2c98c4918d0f87a446ce256c00946c98cabe005923</citedby><cites>FETCH-LOGICAL-c511t-581ad496feffdf3ff50a6ad2c98c4918d0f87a446ce256c00946c98cabe005923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0363-5023(98)80161-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2389640$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9763260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tham, Stephen K.Y.</creatorcontrib><creatorcontrib>Morrison, Wayne A.</creatorcontrib><title>Motor collateral sprouting through an end-to-side nerve repair</title><title>The Journal of hand surgery (American ed.)</title><addtitle>J Hand Surg Am</addtitle><description>The outcome of end-to-side repair of peripheral nerves was investigated. The sciatic nerve in 10 male Sprague-Dawley rats was dissected to its tibioperoneal junction. The nerve to the medial gastrocnemius muscle, branching from the tibial nerve, was ligated at its origin and divided. Its distal end was sutured to an epineurial window on the side of the intact tibial nerve 1 cm distally. At 12 weeks, physiologic evaluation of the medial gastrocnemius muscle and analyses of histologic preparations of nerve and muscle were performed. The results showed that reinnervation successfully occurred in 8 rat media gastrocnemii. The mean weight of the reinnervated medial gastrocnemius was 73% of the contralateral normal muscle, the mean muscle fiber cross-sectional area of the reinnervated muscle was 72%, and the force of contraction was 60%. Analyses of histologic preparations revealed evidence of myelinated axons in the medial gastrocnemius nerve and no evidence of damage to axons of the donor tibial nerve.</description><subject>Anastomosis, Surgical - methods</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Disease Models, Animal</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Motor Neurons - physiology</subject><subject>Muscle Contraction - physiology</subject><subject>Nerve Regeneration - physiology</subject><subject>Psoas Muscles - innervation</subject><subject>Psoas Muscles - pathology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reference Values</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology. Biomaterials. Equipments</subject><subject>Tibial Nerve - pathology</subject><subject>Tibial Nerve - physiology</subject><subject>Tibial Nerve - surgery</subject><issn>0363-5023</issn><issn>1531-6564</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMoWqs_QVhERA-ryWaTJhdFil-geFDPISYTm7Ld1GS34L83taUHL54yZJ4Z3nkQOiL4gmDCL18x5bRkuKJnUpyL_EVKtoUGhFFScsbrbTTYIHtoP6UpxpmibBftyhGnFccDdPUcuhALE5pGdxB1U6R5DH3n28-im-Tqc1LotoDWll0ok7dQtBAXUESYax8P0I7TTYLD9TtE73e3b-OH8unl_nF881QaRkhXMkG0rSV34Jx11DmGNde2MlKYWhJhsRMjXdfcQMW4wVjmMvf0B2DMZEWH6HS1N4f76iF1auaTgRy6hdAnNaIyHyRoBo__gNPQxzZnUxXBOQKXJENsBZkYUorg1Dz6mY7fimC1lKt-5aqlOSWF-pWrWJ47Wi_vP2ZgN1Nrm7l_su7rZHTjom6NTxusokLyeoldrzDIxhYeokrGQ2vA-gimUzb4f4L8ANMzlOk</recordid><startdate>19980901</startdate><enddate>19980901</enddate><creator>Tham, Stephen K.Y.</creator><creator>Morrison, Wayne A.</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Science Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>19980901</creationdate><title>Motor collateral sprouting through an end-to-side nerve repair</title><author>Tham, Stephen K.Y. ; Morrison, Wayne A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-581ad496feffdf3ff50a6ad2c98c4918d0f87a446ce256c00946c98cabe005923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Anastomosis, Surgical - methods</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Disease Models, Animal</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Motor Neurons - physiology</topic><topic>Muscle Contraction - physiology</topic><topic>Nerve Regeneration - physiology</topic><topic>Psoas Muscles - innervation</topic><topic>Psoas Muscles - pathology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reference Values</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Technology. Biomaterials. Equipments</topic><topic>Tibial Nerve - pathology</topic><topic>Tibial Nerve - physiology</topic><topic>Tibial Nerve - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tham, Stephen K.Y.</creatorcontrib><creatorcontrib>Morrison, Wayne A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of hand surgery (American ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tham, Stephen K.Y.</au><au>Morrison, Wayne A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Motor collateral sprouting through an end-to-side nerve repair</atitle><jtitle>The Journal of hand surgery (American ed.)</jtitle><addtitle>J Hand Surg Am</addtitle><date>1998-09-01</date><risdate>1998</risdate><volume>23</volume><issue>5</issue><spage>844</spage><epage>851</epage><pages>844-851</pages><issn>0363-5023</issn><eissn>1531-6564</eissn><coden>JHSUDV</coden><abstract>The outcome of end-to-side repair of peripheral nerves was investigated. The sciatic nerve in 10 male Sprague-Dawley rats was dissected to its tibioperoneal junction. The nerve to the medial gastrocnemius muscle, branching from the tibial nerve, was ligated at its origin and divided. Its distal end was sutured to an epineurial window on the side of the intact tibial nerve 1 cm distally. At 12 weeks, physiologic evaluation of the medial gastrocnemius muscle and analyses of histologic preparations of nerve and muscle were performed. The results showed that reinnervation successfully occurred in 8 rat media gastrocnemii. The mean weight of the reinnervated medial gastrocnemius was 73% of the contralateral normal muscle, the mean muscle fiber cross-sectional area of the reinnervated muscle was 72%, and the force of contraction was 60%. Analyses of histologic preparations revealed evidence of myelinated axons in the medial gastrocnemius nerve and no evidence of damage to axons of the donor tibial nerve.</abstract><cop>New york, NY</cop><pub>Elsevier Inc</pub><pmid>9763260</pmid><doi>10.1016/S0363-5023(98)80161-5</doi><tpages>8</tpages></addata></record> |
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| ispartof | The Journal of hand surgery (American ed.), 1998-09, Vol.23 (5), p.844-851 |
| issn | 0363-5023 1531-6564 |
| language | eng |
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| subjects | Anastomosis, Surgical - methods Animals Biological and medical sciences Disease Models, Animal Male Medical sciences Motor Neurons - physiology Muscle Contraction - physiology Nerve Regeneration - physiology Psoas Muscles - innervation Psoas Muscles - pathology Rats Rats, Sprague-Dawley Reference Values Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Tibial Nerve - pathology Tibial Nerve - physiology Tibial Nerve - surgery |
| title | Motor collateral sprouting through an end-to-side nerve repair |
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