Renal transplantation in Alport's syndrome: anti-glomerular basement membrane glomerulonephritis in the allograft
Eleven patients with Alport's syndrome had renal transplantation between 1963 and 1980. The mean follow-up is 6 years (6 months to 14 years). All 11 patients are currently alive. Ten have functioning grafts, and in nine the serum creatinine concentration is less than 2 mg/dl. Three patients rec...
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| Veröffentlicht in: | Mayo Clinic proceedings 1982-01, Vol.57 (1), p.35-43 |
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| creator | Milliner, D S Pierides, A M Holley, K E |
| description | Eleven patients with Alport's syndrome had renal transplantation between 1963 and 1980. The mean follow-up is 6 years (6 months to 14 years). All 11 patients are currently alive. Ten have functioning grafts, and in nine the serum creatinine concentration is less than 2 mg/dl. Three patients received a second allograft. Histologic study of the allografts that were lost revealed a diffuse crescentic glomerulonephritis with strongly positive linear IgG staining of the glomerular basement membrane in the allografts of two of the three patients; circulating antiglomerular basement membrane antibodies were present in one patient. These two patients had successful retransplantation and they remain well 1 1/2 and 4 1/2 years later. Renal transplantation in patients with Alport's syndrome is a worthwhile and very satisfactory procedure. |
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The mean follow-up is 6 years (6 months to 14 years). All 11 patients are currently alive. Ten have functioning grafts, and in nine the serum creatinine concentration is less than 2 mg/dl. Three patients received a second allograft. Histologic study of the allografts that were lost revealed a diffuse crescentic glomerulonephritis with strongly positive linear IgG staining of the glomerular basement membrane in the allografts of two of the three patients; circulating antiglomerular basement membrane antibodies were present in one patient. These two patients had successful retransplantation and they remain well 1 1/2 and 4 1/2 years later. Renal transplantation in patients with Alport's syndrome is a worthwhile and very satisfactory procedure.</description><identifier>ISSN: 0025-6196</identifier><identifier>PMID: 7033680</identifier><language>eng</language><publisher>England</publisher><subject>Adolescent ; Adult ; Basement Membrane - immunology ; Basement Membrane - pathology ; Evaluation Studies as Topic ; Female ; Glomerulonephritis - etiology ; Glomerulonephritis - immunology ; Glomerulonephritis - pathology ; Graft Rejection ; Humans ; Kidney - immunology ; Kidney Glomerulus - immunology ; Kidney Glomerulus - pathology ; Kidney Transplantation ; Male ; Middle Aged ; Nephritis, Hereditary - immunology ; Nephritis, Hereditary - surgery ; Reoperation ; Transplantation, Homologous</subject><ispartof>Mayo Clinic proceedings, 1982-01, Vol.57 (1), p.35-43</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7033680$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Milliner, D S</creatorcontrib><creatorcontrib>Pierides, A M</creatorcontrib><creatorcontrib>Holley, K E</creatorcontrib><title>Renal transplantation in Alport's syndrome: anti-glomerular basement membrane glomerulonephritis in the allograft</title><title>Mayo Clinic proceedings</title><addtitle>Mayo Clin Proc</addtitle><description>Eleven patients with Alport's syndrome had renal transplantation between 1963 and 1980. The mean follow-up is 6 years (6 months to 14 years). All 11 patients are currently alive. Ten have functioning grafts, and in nine the serum creatinine concentration is less than 2 mg/dl. Three patients received a second allograft. Histologic study of the allografts that were lost revealed a diffuse crescentic glomerulonephritis with strongly positive linear IgG staining of the glomerular basement membrane in the allografts of two of the three patients; circulating antiglomerular basement membrane antibodies were present in one patient. These two patients had successful retransplantation and they remain well 1 1/2 and 4 1/2 years later. Renal transplantation in patients with Alport's syndrome is a worthwhile and very satisfactory procedure.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Basement Membrane - immunology</subject><subject>Basement Membrane - pathology</subject><subject>Evaluation Studies as Topic</subject><subject>Female</subject><subject>Glomerulonephritis - etiology</subject><subject>Glomerulonephritis - immunology</subject><subject>Glomerulonephritis - pathology</subject><subject>Graft Rejection</subject><subject>Humans</subject><subject>Kidney - immunology</subject><subject>Kidney Glomerulus - immunology</subject><subject>Kidney Glomerulus - pathology</subject><subject>Kidney Transplantation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nephritis, Hereditary - immunology</subject><subject>Nephritis, Hereditary - surgery</subject><subject>Reoperation</subject><subject>Transplantation, Homologous</subject><issn>0025-6196</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kE1LAzEYhHNQaq3-BCEnPS1kk2Y38VaKX1AQRM9Lkn3TruRjm2QP_feuWE8zMMMDMxdoSQjlVVPL5gpd5_xNCGmlXC_QoiWMNYIs0fEDgnK4JBXy6FQoqgwx4CHgjRtjKg8Z51PoU_TwiOd4qPZu9mlyKmGtMngIBXvweiYA_g9jgPGQhjLkX1Q5AFbOxX1SttygS6tchtuzrtDX89Pn9rXavb-8bTe7aqSkKZUkRlhuad2YmmnCgdZGC8Ot5lwzqhTltTCCSWEaCdL2WgKnUolea2oFYyt0_8cdUzxOkEvnh2zAzSMhTrlrmWzqtSBz8e5cnLSHvhvT4FU6deeP2A-Yv2Uc</recordid><startdate>198201</startdate><enddate>198201</enddate><creator>Milliner, D S</creator><creator>Pierides, A M</creator><creator>Holley, K E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198201</creationdate><title>Renal transplantation in Alport's syndrome: anti-glomerular basement membrane glomerulonephritis in the allograft</title><author>Milliner, D S ; Pierides, A M ; Holley, K E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p206t-90c8f5f216c13b05e21cb8c5fb55b32aa2518c8398c69e9fdb9e529a8dbb2f833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Basement Membrane - immunology</topic><topic>Basement Membrane - pathology</topic><topic>Evaluation Studies as Topic</topic><topic>Female</topic><topic>Glomerulonephritis - etiology</topic><topic>Glomerulonephritis - immunology</topic><topic>Glomerulonephritis - pathology</topic><topic>Graft Rejection</topic><topic>Humans</topic><topic>Kidney - immunology</topic><topic>Kidney Glomerulus - immunology</topic><topic>Kidney Glomerulus - pathology</topic><topic>Kidney Transplantation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nephritis, Hereditary - immunology</topic><topic>Nephritis, Hereditary - surgery</topic><topic>Reoperation</topic><topic>Transplantation, Homologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Milliner, D S</creatorcontrib><creatorcontrib>Pierides, A M</creatorcontrib><creatorcontrib>Holley, K E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Mayo Clinic proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Milliner, D S</au><au>Pierides, A M</au><au>Holley, K E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renal transplantation in Alport's syndrome: anti-glomerular basement membrane glomerulonephritis in the allograft</atitle><jtitle>Mayo Clinic proceedings</jtitle><addtitle>Mayo Clin Proc</addtitle><date>1982-01</date><risdate>1982</risdate><volume>57</volume><issue>1</issue><spage>35</spage><epage>43</epage><pages>35-43</pages><issn>0025-6196</issn><abstract>Eleven patients with Alport's syndrome had renal transplantation between 1963 and 1980. The mean follow-up is 6 years (6 months to 14 years). All 11 patients are currently alive. Ten have functioning grafts, and in nine the serum creatinine concentration is less than 2 mg/dl. Three patients received a second allograft. Histologic study of the allografts that were lost revealed a diffuse crescentic glomerulonephritis with strongly positive linear IgG staining of the glomerular basement membrane in the allografts of two of the three patients; circulating antiglomerular basement membrane antibodies were present in one patient. These two patients had successful retransplantation and they remain well 1 1/2 and 4 1/2 years later. Renal transplantation in patients with Alport's syndrome is a worthwhile and very satisfactory procedure.</abstract><cop>England</cop><pmid>7033680</pmid><tpages>9</tpages></addata></record> |
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| ispartof | Mayo Clinic proceedings, 1982-01, Vol.57 (1), p.35-43 |
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| subjects | Adolescent Adult Basement Membrane - immunology Basement Membrane - pathology Evaluation Studies as Topic Female Glomerulonephritis - etiology Glomerulonephritis - immunology Glomerulonephritis - pathology Graft Rejection Humans Kidney - immunology Kidney Glomerulus - immunology Kidney Glomerulus - pathology Kidney Transplantation Male Middle Aged Nephritis, Hereditary - immunology Nephritis, Hereditary - surgery Reoperation Transplantation, Homologous |
| title | Renal transplantation in Alport's syndrome: anti-glomerular basement membrane glomerulonephritis in the allograft |
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