Evoked potential alterations following prenatal methyl mercury exposure
Pregnant hooded rats were administered either 5 mg/kg CH 3 Hg or 0 mg/kg CH 3 Hg by gastric intubation on day seven of gestation. Female offspring were implanted with recording electrodes 60 days after birth and had their cortically recorded visual evoked potentials studied at four different flash i...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1978-02, Vol.8 (2), p.137-141 |
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| container_title | Pharmacology, biochemistry and behavior |
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| creator | Dyer, Robert S. Eccles, Christine U. Annau, Zoltan |
| description | Pregnant hooded rats were administered either 5 mg/kg CH
3 Hg or 0 mg/kg CH
3 Hg by gastric intubation on day seven of gestation. Female offspring were implanted with recording electrodes 60 days after birth and had their cortically recorded visual evoked potentials studied at four different flash intensities. Mercury exposed animals had higher P1-N1 and N1-P2 amplitudes and shorter P2 and N2 latencies than controls. The data provides evidence that a single ingestion of CH
3 Hg by pregnant rats is sufficient to produce long term alterations in CNS activity. |
| doi_str_mv | 10.1016/0091-3057(78)90330-1 |
| format | Article |
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3 Hg or 0 mg/kg CH
3 Hg by gastric intubation on day seven of gestation. Female offspring were implanted with recording electrodes 60 days after birth and had their cortically recorded visual evoked potentials studied at four different flash intensities. Mercury exposed animals had higher P1-N1 and N1-P2 amplitudes and shorter P2 and N2 latencies than controls. The data provides evidence that a single ingestion of CH
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3 Hg or 0 mg/kg CH
3 Hg by gastric intubation on day seven of gestation. Female offspring were implanted with recording electrodes 60 days after birth and had their cortically recorded visual evoked potentials studied at four different flash intensities. Mercury exposed animals had higher P1-N1 and N1-P2 amplitudes and shorter P2 and N2 latencies than controls. The data provides evidence that a single ingestion of CH
3 Hg by pregnant rats is sufficient to produce long term alterations in CNS activity.</description><subject>Animals</subject><subject>Evoked Potentials - drug effects</subject><subject>Female</subject><subject>Females</subject><subject>Hooded rats</subject><subject>Maternal-Fetal Exchange</subject><subject>Methyl mercury</subject><subject>Methylmercury Compounds - pharmacology</subject><subject>Photic Stimulation</subject><subject>Pregnancy</subject><subject>Prenatal</subject><subject>Rats</subject><subject>Toxicity</subject><subject>Visual evoked potentials</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLlOxDAURS3ENix_QJEKQRHwix07aZAQYpOQaKC2HPsFDJk42A4wf0-GQVNS3eIu0j2EHAE9AwrinNIackZLeSKr05oyRnPYIDOoJMtLkHKTzNaRXbIX4xullBdC7pDtUpQ1gxm5vf7072izwSfsk9NdpruEQSfn-5i1vuv8l-tfsiFgr9NkzzG9LpYSzBgWGX4PPo4BD8hWq7uIh3-6T55vrp-u7vKHx9v7q8uH3LBSpLwoa2p1w61hBeVQtLbRwIVtqgqQW8FrA21DgdclVIVojODAK8oM0wIKwdg-OV7tDsF_jBiTmrtosOt0j36MSrK6pLUUU5Cvgib4GAO2aghursNCAVVLfGrJRi3ZKFmpX3wKptrR3_7YzNGuSytek32xsnH6-OkwqGgc9gatC2iSst79v_8D32R-rQ</recordid><startdate>197802</startdate><enddate>197802</enddate><creator>Dyer, Robert S.</creator><creator>Eccles, Christine U.</creator><creator>Annau, Zoltan</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197802</creationdate><title>Evoked potential alterations following prenatal methyl mercury exposure</title><author>Dyer, Robert S. ; Eccles, Christine U. ; Annau, Zoltan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-2590dab4dc320412fdba146db881e4d649c1fb014951826bc6414803c3a612633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Animals</topic><topic>Evoked Potentials - drug effects</topic><topic>Female</topic><topic>Females</topic><topic>Hooded rats</topic><topic>Maternal-Fetal Exchange</topic><topic>Methyl mercury</topic><topic>Methylmercury Compounds - pharmacology</topic><topic>Photic Stimulation</topic><topic>Pregnancy</topic><topic>Prenatal</topic><topic>Rats</topic><topic>Toxicity</topic><topic>Visual evoked potentials</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dyer, Robert S.</creatorcontrib><creatorcontrib>Eccles, Christine U.</creatorcontrib><creatorcontrib>Annau, Zoltan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dyer, Robert S.</au><au>Eccles, Christine U.</au><au>Annau, Zoltan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evoked potential alterations following prenatal methyl mercury exposure</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1978-02</date><risdate>1978</risdate><volume>8</volume><issue>2</issue><spage>137</spage><epage>141</epage><pages>137-141</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><abstract>Pregnant hooded rats were administered either 5 mg/kg CH
3 Hg or 0 mg/kg CH
3 Hg by gastric intubation on day seven of gestation. Female offspring were implanted with recording electrodes 60 days after birth and had their cortically recorded visual evoked potentials studied at four different flash intensities. Mercury exposed animals had higher P1-N1 and N1-P2 amplitudes and shorter P2 and N2 latencies than controls. The data provides evidence that a single ingestion of CH
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| fulltext | fulltext |
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| ispartof | Pharmacology, biochemistry and behavior, 1978-02, Vol.8 (2), p.137-141 |
| issn | 0091-3057 1873-5177 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Evoked Potentials - drug effects Female Females Hooded rats Maternal-Fetal Exchange Methyl mercury Methylmercury Compounds - pharmacology Photic Stimulation Pregnancy Prenatal Rats Toxicity Visual evoked potentials |
| title | Evoked potential alterations following prenatal methyl mercury exposure |
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