Field efficacy of doramectin pour-on against naturally-acquired, gastrointestinal nematodes of cattle in North America
Seven studies were conducted under field conditions in North America to evaluate the therapeutic efficacy of doramectin in a pour-on formulation at a dosage of 500 μg/kg (1 ml/10 kg) for cattle harboring naturally-acquired infections of gastrointestinal nematodes, including species of Haemonchus, Os...
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| Veröffentlicht in: | Veterinary parasitology 1998-06, Vol.77 (4), p.259-265 |
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| creator | Conder, G.A. Rooney, K.A. Illyes, E.F. Keller, D.S. Meinert, T.R. Logan, N.B. |
| description | Seven studies were conducted under field conditions in North America to evaluate the therapeutic efficacy of doramectin in a pour-on formulation at a dosage of 500
μg/kg (1
ml/10
kg) for cattle harboring naturally-acquired infections of gastrointestinal nematodes, including species of
Haemonchus, Ostertagia, Trichostrongylus, Bunostomum, Cooperia, and
Oesophagostomum. In each study, 40 to 100 cattle were randomly allocated to a saline- or doramectin-treated group in a tiered manner based on Day −7 bodyweight. On Day 0, the cattle received either saline or doramectin topically, according to their treatment group. Weather and safety observations were made following treatment. No adverse reaction to treatment was observed at any time during these studies. Fecal egg count (FEC) determinations were carried out on each animal on Days −7, 0, 7, 14, and 21. Reductions in FEC for the doramectin-treated animals compared to saline-treated cattle were ≥96.0% by Day −7 and ≥99.0% on Days 14 and 21 for each study. Across all studies regardless of weather conditions, the reduction by Day 21 for the doramectin-treated animals compared to saline controls was 99.7% (
p≤0.0001) and compared to pretreatment levels in doramectin-treated cattle was 99.9% (
p≤0.0001). Doramectin pour-on should provide a useful new treatment for controlling nematode parasites of cattle. |
| doi_str_mv | 10.1016/S0304-4017(98)00110-1 |
| format | Article |
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μg/kg (1
ml/10
kg) for cattle harboring naturally-acquired infections of gastrointestinal nematodes, including species of
Haemonchus, Ostertagia, Trichostrongylus, Bunostomum, Cooperia, and
Oesophagostomum. In each study, 40 to 100 cattle were randomly allocated to a saline- or doramectin-treated group in a tiered manner based on Day −7 bodyweight. On Day 0, the cattle received either saline or doramectin topically, according to their treatment group. Weather and safety observations were made following treatment. No adverse reaction to treatment was observed at any time during these studies. Fecal egg count (FEC) determinations were carried out on each animal on Days −7, 0, 7, 14, and 21. Reductions in FEC for the doramectin-treated animals compared to saline-treated cattle were ≥96.0% by Day −7 and ≥99.0% on Days 14 and 21 for each study. Across all studies regardless of weather conditions, the reduction by Day 21 for the doramectin-treated animals compared to saline controls was 99.7% (
p≤0.0001) and compared to pretreatment levels in doramectin-treated cattle was 99.9% (
p≤0.0001). Doramectin pour-on should provide a useful new treatment for controlling nematode parasites of cattle.</description><identifier>ISSN: 0304-4017</identifier><identifier>EISSN: 1873-2550</identifier><identifier>DOI: 10.1016/S0304-4017(98)00110-1</identifier><identifier>PMID: 9763316</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject><![CDATA[AMERICA DEL NORTE ; AMERIQUE DU NORD ; Animals ; ANTHELMINTHIQUE ; ANTHELMINTICS ; Anthelmintics - administration & dosage ; Anthelmintics - pharmacology ; Anthelmintics - therapeutic use ; ANTIHELMINTICOS ; APPAREIL DIGESTIF ; BOVIN ; CATTLE ; Cattle Diseases - parasitology ; Cattle Diseases - prevention & control ; Cattle nematode ; DIGESTIVE SYSTEM ; Doramectin ; DRUGS ; Efficacy ; Endectocide ; Feces - parasitology ; GANADO BOVINO ; Intestinal Diseases, Parasitic - prevention & control ; Intestinal Diseases, Parasitic - veterinary ; Ivermectin - administration & dosage ; Ivermectin - analogs & derivatives ; Ivermectin - pharmacology ; Ivermectin - therapeutic use ; MEDICAMENT ; MEDICAMENTOS ; NEMATODA ; NORTH AMERICA ; Parasite Egg Count - veterinary ; Pour-on ; Random Allocation ; SISTEMA DIGESTIVO ; Trichostrongyloidea - drug effects ; Trichostrongyloidiasis - prevention & control ; Trichostrongyloidiasis - veterinary ; United States ; Weather ; Weight Gain]]></subject><ispartof>Veterinary parasitology, 1998-06, Vol.77 (4), p.259-265</ispartof><rights>1998 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-1ebf5112d748c63b80f022bfbce7fa81f6ca1c0ac87a596bfa24fedb07eb46b63</citedby><cites>FETCH-LOGICAL-c382t-1ebf5112d748c63b80f022bfbce7fa81f6ca1c0ac87a596bfa24fedb07eb46b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0304-4017(98)00110-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9763316$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Conder, G.A.</creatorcontrib><creatorcontrib>Rooney, K.A.</creatorcontrib><creatorcontrib>Illyes, E.F.</creatorcontrib><creatorcontrib>Keller, D.S.</creatorcontrib><creatorcontrib>Meinert, T.R.</creatorcontrib><creatorcontrib>Logan, N.B.</creatorcontrib><title>Field efficacy of doramectin pour-on against naturally-acquired, gastrointestinal nematodes of cattle in North America</title><title>Veterinary parasitology</title><addtitle>Vet Parasitol</addtitle><description>Seven studies were conducted under field conditions in North America to evaluate the therapeutic efficacy of doramectin in a pour-on formulation at a dosage of 500
μg/kg (1
ml/10
kg) for cattle harboring naturally-acquired infections of gastrointestinal nematodes, including species of
Haemonchus, Ostertagia, Trichostrongylus, Bunostomum, Cooperia, and
Oesophagostomum. In each study, 40 to 100 cattle were randomly allocated to a saline- or doramectin-treated group in a tiered manner based on Day −7 bodyweight. On Day 0, the cattle received either saline or doramectin topically, according to their treatment group. Weather and safety observations were made following treatment. No adverse reaction to treatment was observed at any time during these studies. Fecal egg count (FEC) determinations were carried out on each animal on Days −7, 0, 7, 14, and 21. Reductions in FEC for the doramectin-treated animals compared to saline-treated cattle were ≥96.0% by Day −7 and ≥99.0% on Days 14 and 21 for each study. Across all studies regardless of weather conditions, the reduction by Day 21 for the doramectin-treated animals compared to saline controls was 99.7% (
p≤0.0001) and compared to pretreatment levels in doramectin-treated cattle was 99.9% (
p≤0.0001). Doramectin pour-on should provide a useful new treatment for controlling nematode parasites of cattle.</description><subject>AMERICA DEL NORTE</subject><subject>AMERIQUE DU NORD</subject><subject>Animals</subject><subject>ANTHELMINTHIQUE</subject><subject>ANTHELMINTICS</subject><subject>Anthelmintics - administration & dosage</subject><subject>Anthelmintics - pharmacology</subject><subject>Anthelmintics - therapeutic use</subject><subject>ANTIHELMINTICOS</subject><subject>APPAREIL DIGESTIF</subject><subject>BOVIN</subject><subject>CATTLE</subject><subject>Cattle Diseases - parasitology</subject><subject>Cattle Diseases - prevention & control</subject><subject>Cattle nematode</subject><subject>DIGESTIVE SYSTEM</subject><subject>Doramectin</subject><subject>DRUGS</subject><subject>Efficacy</subject><subject>Endectocide</subject><subject>Feces - parasitology</subject><subject>GANADO BOVINO</subject><subject>Intestinal Diseases, Parasitic - prevention & control</subject><subject>Intestinal Diseases, Parasitic - veterinary</subject><subject>Ivermectin - administration & dosage</subject><subject>Ivermectin - analogs & derivatives</subject><subject>Ivermectin - pharmacology</subject><subject>Ivermectin - therapeutic use</subject><subject>MEDICAMENT</subject><subject>MEDICAMENTOS</subject><subject>NEMATODA</subject><subject>NORTH AMERICA</subject><subject>Parasite Egg Count - veterinary</subject><subject>Pour-on</subject><subject>Random Allocation</subject><subject>SISTEMA DIGESTIVO</subject><subject>Trichostrongyloidea - drug effects</subject><subject>Trichostrongyloidiasis - prevention & control</subject><subject>Trichostrongyloidiasis - veterinary</subject><subject>United States</subject><subject>Weather</subject><subject>Weight Gain</subject><issn>0304-4017</issn><issn>1873-2550</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhkVpSDdpf0JAp9JA3cz426cSQpMWluSQ9izG8mirYlsbSQ7sv682u6THnubwfszwjBAXCF8QsL56hALKrARsPnXtJQAiZPhGrLBtiiyvKngrVq-Wd-IshD8AUELdnIrTrqmLAuuVeL61PA6SjbGa9E46IwfnaWId7Sy3bvGZmyVtyM4hypni4mkcdxnpp8V6Hj7LDYXonZ0jhxShUc48UXQDh32ZphhHlqnr3vn4W15P7NOm9-LE0Bj4w3Gei1-3337efM_WD3c_bq7XmS7aPGbIvakQ86EpW10XfQsG8rw3vebGUIum1oQaSLcNVV3dG8pLw0MPDfdl3dfFufh46N1697SkC9Vkg-ZxpJndElRTdGWHZZGM1cGovQvBs1FbbyfyO4Wg9rzVC2-1h6m6Vr3wVphyF8cFSz_x8Jo6Av6nG3KKNt4Gdb_GruvSLwDbpH896JwoPFv2KmjLs-Yh0dVRDc7-54K_7uabKA</recordid><startdate>19980630</startdate><enddate>19980630</enddate><creator>Conder, G.A.</creator><creator>Rooney, K.A.</creator><creator>Illyes, E.F.</creator><creator>Keller, D.S.</creator><creator>Meinert, T.R.</creator><creator>Logan, N.B.</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980630</creationdate><title>Field efficacy of doramectin pour-on against naturally-acquired, gastrointestinal nematodes of cattle in North America</title><author>Conder, G.A. ; Rooney, K.A. ; Illyes, E.F. ; Keller, D.S. ; Meinert, T.R. ; Logan, N.B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-1ebf5112d748c63b80f022bfbce7fa81f6ca1c0ac87a596bfa24fedb07eb46b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>AMERICA DEL NORTE</topic><topic>AMERIQUE DU NORD</topic><topic>Animals</topic><topic>ANTHELMINTHIQUE</topic><topic>ANTHELMINTICS</topic><topic>Anthelmintics - administration & dosage</topic><topic>Anthelmintics - pharmacology</topic><topic>Anthelmintics - therapeutic use</topic><topic>ANTIHELMINTICOS</topic><topic>APPAREIL DIGESTIF</topic><topic>BOVIN</topic><topic>CATTLE</topic><topic>Cattle Diseases - parasitology</topic><topic>Cattle Diseases - prevention & control</topic><topic>Cattle nematode</topic><topic>DIGESTIVE SYSTEM</topic><topic>Doramectin</topic><topic>DRUGS</topic><topic>Efficacy</topic><topic>Endectocide</topic><topic>Feces - parasitology</topic><topic>GANADO BOVINO</topic><topic>Intestinal Diseases, Parasitic - prevention & control</topic><topic>Intestinal Diseases, Parasitic - veterinary</topic><topic>Ivermectin - administration & dosage</topic><topic>Ivermectin - analogs & derivatives</topic><topic>Ivermectin - pharmacology</topic><topic>Ivermectin - therapeutic use</topic><topic>MEDICAMENT</topic><topic>MEDICAMENTOS</topic><topic>NEMATODA</topic><topic>NORTH AMERICA</topic><topic>Parasite Egg Count - veterinary</topic><topic>Pour-on</topic><topic>Random Allocation</topic><topic>SISTEMA DIGESTIVO</topic><topic>Trichostrongyloidea - drug effects</topic><topic>Trichostrongyloidiasis - prevention & control</topic><topic>Trichostrongyloidiasis - veterinary</topic><topic>United States</topic><topic>Weather</topic><topic>Weight Gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Conder, G.A.</creatorcontrib><creatorcontrib>Rooney, K.A.</creatorcontrib><creatorcontrib>Illyes, E.F.</creatorcontrib><creatorcontrib>Keller, D.S.</creatorcontrib><creatorcontrib>Meinert, T.R.</creatorcontrib><creatorcontrib>Logan, N.B.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Conder, G.A.</au><au>Rooney, K.A.</au><au>Illyes, E.F.</au><au>Keller, D.S.</au><au>Meinert, T.R.</au><au>Logan, N.B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Field efficacy of doramectin pour-on against naturally-acquired, gastrointestinal nematodes of cattle in North America</atitle><jtitle>Veterinary parasitology</jtitle><addtitle>Vet Parasitol</addtitle><date>1998-06-30</date><risdate>1998</risdate><volume>77</volume><issue>4</issue><spage>259</spage><epage>265</epage><pages>259-265</pages><issn>0304-4017</issn><eissn>1873-2550</eissn><abstract>Seven studies were conducted under field conditions in North America to evaluate the therapeutic efficacy of doramectin in a pour-on formulation at a dosage of 500
μg/kg (1
ml/10
kg) for cattle harboring naturally-acquired infections of gastrointestinal nematodes, including species of
Haemonchus, Ostertagia, Trichostrongylus, Bunostomum, Cooperia, and
Oesophagostomum. In each study, 40 to 100 cattle were randomly allocated to a saline- or doramectin-treated group in a tiered manner based on Day −7 bodyweight. On Day 0, the cattle received either saline or doramectin topically, according to their treatment group. Weather and safety observations were made following treatment. No adverse reaction to treatment was observed at any time during these studies. Fecal egg count (FEC) determinations were carried out on each animal on Days −7, 0, 7, 14, and 21. Reductions in FEC for the doramectin-treated animals compared to saline-treated cattle were ≥96.0% by Day −7 and ≥99.0% on Days 14 and 21 for each study. Across all studies regardless of weather conditions, the reduction by Day 21 for the doramectin-treated animals compared to saline controls was 99.7% (
p≤0.0001) and compared to pretreatment levels in doramectin-treated cattle was 99.9% (
p≤0.0001). Doramectin pour-on should provide a useful new treatment for controlling nematode parasites of cattle.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>9763316</pmid><doi>10.1016/S0304-4017(98)00110-1</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-4017 |
| ispartof | Veterinary parasitology, 1998-06, Vol.77 (4), p.259-265 |
| issn | 0304-4017 1873-2550 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73949143 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | AMERICA DEL NORTE AMERIQUE DU NORD Animals ANTHELMINTHIQUE ANTHELMINTICS Anthelmintics - administration & dosage Anthelmintics - pharmacology Anthelmintics - therapeutic use ANTIHELMINTICOS APPAREIL DIGESTIF BOVIN CATTLE Cattle Diseases - parasitology Cattle Diseases - prevention & control Cattle nematode DIGESTIVE SYSTEM Doramectin DRUGS Efficacy Endectocide Feces - parasitology GANADO BOVINO Intestinal Diseases, Parasitic - prevention & control Intestinal Diseases, Parasitic - veterinary Ivermectin - administration & dosage Ivermectin - analogs & derivatives Ivermectin - pharmacology Ivermectin - therapeutic use MEDICAMENT MEDICAMENTOS NEMATODA NORTH AMERICA Parasite Egg Count - veterinary Pour-on Random Allocation SISTEMA DIGESTIVO Trichostrongyloidea - drug effects Trichostrongyloidiasis - prevention & control Trichostrongyloidiasis - veterinary United States Weather Weight Gain |
| title | Field efficacy of doramectin pour-on against naturally-acquired, gastrointestinal nematodes of cattle in North America |
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