Malignant leydig cell tumor: Clinical, histologic and electron microscopic features
A 51‐year‐old man had a malignant Leydig cell tumor of the testis with elevation of serum estrone and androstenedione as well as urine chorionic gonadotropin. The fine structural features of the neoplasm resembled those of nontumorous Leydig cells as well as cells of Leydig cell adenomas, except for...
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| Veröffentlicht in: | Cancer 1982-02, Vol.49 (4), p.714-721 |
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| container_title | Cancer |
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| creator | Feldman, P. S. Kovacs, K. Horvath, E. Adelson, G. L. |
| description | A 51‐year‐old man had a malignant Leydig cell tumor of the testis with elevation of serum estrone and androstenedione as well as urine chorionic gonadotropin. The fine structural features of the neoplasm resembled those of nontumorous Leydig cells as well as cells of Leydig cell adenomas, except for, nuclear pleomorphism, the absence of Reinke's crystals and the infrequency of microvilli. The abundance of smooth surfaced endoplasmic reticulum, well‐developed mitochondria with tubular and vesicular cristae were regarded as representing ultrastructural expressions of enhanced secretory activity and consistent with the biochemical findings of increased hormonal production by tumor cells. Since Leydig cells have distinct ultrastructural features, ultrastructural investigation represents a valuable tool in establishing the Leydig cell origin of a tummor. |
| doi_str_mv | 10.1002/1097-0142(19820215)49:4<714::AID-CNCR2820490420>3.0.CO;2-A |
| format | Article |
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S. ; Kovacs, K. ; Horvath, E. ; Adelson, G. L.</creator><creatorcontrib>Feldman, P. S. ; Kovacs, K. ; Horvath, E. ; Adelson, G. L.</creatorcontrib><description>A 51‐year‐old man had a malignant Leydig cell tumor of the testis with elevation of serum estrone and androstenedione as well as urine chorionic gonadotropin. The fine structural features of the neoplasm resembled those of nontumorous Leydig cells as well as cells of Leydig cell adenomas, except for, nuclear pleomorphism, the absence of Reinke's crystals and the infrequency of microvilli. The abundance of smooth surfaced endoplasmic reticulum, well‐developed mitochondria with tubular and vesicular cristae were regarded as representing ultrastructural expressions of enhanced secretory activity and consistent with the biochemical findings of increased hormonal production by tumor cells. Since Leydig cells have distinct ultrastructural features, ultrastructural investigation represents a valuable tool in establishing the Leydig cell origin of a tummor.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19820215)49:4<714::AID-CNCR2820490420>3.0.CO;2-A</identifier><identifier>PMID: 7055782</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Androstenedione - blood ; Chorionic Gonadotropin - urine ; Desmosomes - ultrastructure ; Endoplasmic Reticulum - ultrastructure ; Estrone - blood ; Humans ; Intercellular Junctions - ultrastructure ; Leydig Cell Tumor - blood ; Leydig Cell Tumor - pathology ; Leydig Cell Tumor - ultrastructure ; Male ; Middle Aged ; Mitochondria - ultrastructure ; Testicular Neoplasms - blood ; Testicular Neoplasms - pathology ; Testicular Neoplasms - ultrastructure ; Testis - pathology</subject><ispartof>Cancer, 1982-02, Vol.49 (4), p.714-721</ispartof><rights>Copyright © 1982 American Cancer Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3830-3eb8c4de5b2a78340920a65131981beb68c99de8d74c450d5401a69ee3e4c3793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7055782$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feldman, P. S.</creatorcontrib><creatorcontrib>Kovacs, K.</creatorcontrib><creatorcontrib>Horvath, E.</creatorcontrib><creatorcontrib>Adelson, G. L.</creatorcontrib><title>Malignant leydig cell tumor: Clinical, histologic and electron microscopic features</title><title>Cancer</title><addtitle>Cancer</addtitle><description>A 51‐year‐old man had a malignant Leydig cell tumor of the testis with elevation of serum estrone and androstenedione as well as urine chorionic gonadotropin. The fine structural features of the neoplasm resembled those of nontumorous Leydig cells as well as cells of Leydig cell adenomas, except for, nuclear pleomorphism, the absence of Reinke's crystals and the infrequency of microvilli. The abundance of smooth surfaced endoplasmic reticulum, well‐developed mitochondria with tubular and vesicular cristae were regarded as representing ultrastructural expressions of enhanced secretory activity and consistent with the biochemical findings of increased hormonal production by tumor cells. Since Leydig cells have distinct ultrastructural features, ultrastructural investigation represents a valuable tool in establishing the Leydig cell origin of a tummor.</description><subject>Androstenedione - blood</subject><subject>Chorionic Gonadotropin - urine</subject><subject>Desmosomes - ultrastructure</subject><subject>Endoplasmic Reticulum - ultrastructure</subject><subject>Estrone - blood</subject><subject>Humans</subject><subject>Intercellular Junctions - ultrastructure</subject><subject>Leydig Cell Tumor - blood</subject><subject>Leydig Cell Tumor - pathology</subject><subject>Leydig Cell Tumor - ultrastructure</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mitochondria - ultrastructure</subject><subject>Testicular Neoplasms - blood</subject><subject>Testicular Neoplasms - pathology</subject><subject>Testicular Neoplasms - ultrastructure</subject><subject>Testis - pathology</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkFuLFDEQRoMo67j6E4R-EgV7rNymk1GEsb0trA54AfGlSKdrxkhfxk43sv_eNDMu6IPgUwin8tWXw9gLDksOIJ5wsEUOXImH3BoBgutHyq7Vs4Kr9Xpz8TIv35cfRCLKghLwXC5hWW6finxzgy2uH99kCwAwuVbyy212J8bv6VoILc_YWQFaF0Ys2Md3rgn7znVj1tBVHfaZp6bJxqnth3VWNqEL3jWPs28hjn3T74PPXFdn1JAfh77L2uCHPvr-kMCO3DgNFO-yWzvXRLp3Os_Z59evPpVv88vtm4tyc5l7aSTkkirjVU26Eq4wUoEV4Faay_RpXlG1Mt7amkxdKK801FoBdytLJEl5WVh5zh4ccw9D_2OiOGIb4lzfddRPEQtplbHapMGvx8G5axxoh4chtG64Qg44G8dZGs7S8LdxVBYVJuOIyTj-aRwlApZbFLhJ4fdPLaaqpfo6-qQ4cTrynyEZ_q_N_1z8F5G_ANa6nac</recordid><startdate>19820215</startdate><enddate>19820215</enddate><creator>Feldman, P. S.</creator><creator>Kovacs, K.</creator><creator>Horvath, E.</creator><creator>Adelson, G. L.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19820215</creationdate><title>Malignant leydig cell tumor: Clinical, histologic and electron microscopic features</title><author>Feldman, P. S. ; Kovacs, K. ; Horvath, E. ; Adelson, G. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3830-3eb8c4de5b2a78340920a65131981beb68c99de8d74c450d5401a69ee3e4c3793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Androstenedione - blood</topic><topic>Chorionic Gonadotropin - urine</topic><topic>Desmosomes - ultrastructure</topic><topic>Endoplasmic Reticulum - ultrastructure</topic><topic>Estrone - blood</topic><topic>Humans</topic><topic>Intercellular Junctions - ultrastructure</topic><topic>Leydig Cell Tumor - blood</topic><topic>Leydig Cell Tumor - pathology</topic><topic>Leydig Cell Tumor - ultrastructure</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mitochondria - ultrastructure</topic><topic>Testicular Neoplasms - blood</topic><topic>Testicular Neoplasms - pathology</topic><topic>Testicular Neoplasms - ultrastructure</topic><topic>Testis - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feldman, P. S.</creatorcontrib><creatorcontrib>Kovacs, K.</creatorcontrib><creatorcontrib>Horvath, E.</creatorcontrib><creatorcontrib>Adelson, G. L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feldman, P. S.</au><au>Kovacs, K.</au><au>Horvath, E.</au><au>Adelson, G. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Malignant leydig cell tumor: Clinical, histologic and electron microscopic features</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1982-02-15</date><risdate>1982</risdate><volume>49</volume><issue>4</issue><spage>714</spage><epage>721</epage><pages>714-721</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>A 51‐year‐old man had a malignant Leydig cell tumor of the testis with elevation of serum estrone and androstenedione as well as urine chorionic gonadotropin. The fine structural features of the neoplasm resembled those of nontumorous Leydig cells as well as cells of Leydig cell adenomas, except for, nuclear pleomorphism, the absence of Reinke's crystals and the infrequency of microvilli. The abundance of smooth surfaced endoplasmic reticulum, well‐developed mitochondria with tubular and vesicular cristae were regarded as representing ultrastructural expressions of enhanced secretory activity and consistent with the biochemical findings of increased hormonal production by tumor cells. Since Leydig cells have distinct ultrastructural features, ultrastructural investigation represents a valuable tool in establishing the Leydig cell origin of a tummor.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>7055782</pmid><doi>10.1002/1097-0142(19820215)49:4<714::AID-CNCR2820490420>3.0.CO;2-A</doi><tpages>8</tpages></addata></record> |
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| ispartof | Cancer, 1982-02, Vol.49 (4), p.714-721 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Androstenedione - blood Chorionic Gonadotropin - urine Desmosomes - ultrastructure Endoplasmic Reticulum - ultrastructure Estrone - blood Humans Intercellular Junctions - ultrastructure Leydig Cell Tumor - blood Leydig Cell Tumor - pathology Leydig Cell Tumor - ultrastructure Male Middle Aged Mitochondria - ultrastructure Testicular Neoplasms - blood Testicular Neoplasms - pathology Testicular Neoplasms - ultrastructure Testis - pathology |
| title | Malignant leydig cell tumor: Clinical, histologic and electron microscopic features |
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