The effects of nitric oxide on the contractility of isolated uterine and aortic rings from pregnant rats
OBJECTIVE: The object was to compare the effects of nitric oxide on isolated uterus and aorta of pregnant rats. STUDY DESIGN: Rings of uterus and thoracic aorta without endothelium from Sprague-Dawley rats at mid and late gestation were used for isometric tension recording. The concentration-respons...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1998-09, Vol.179 (3), p.721-726 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Okawa, Toshiaki Syal, Ashu S. Vedernikov, Yuri P. Saade, George R. Chwalisz, Kristof Garfield, Robert E. |
| description | OBJECTIVE: The object was to compare the effects of nitric oxide on isolated uterus and aorta of pregnant rats.
STUDY DESIGN: Rings of uterus and thoracic aorta without endothelium from Sprague-Dawley rats at mid and late gestation were used for isometric tension recording. The concentration-response curve for diethyl-amine/nitric oxide was studied in the presence or absence of oxyhemoglobin (10
–5 mol/L), or oxyhemoglobin was added after the response to diethylamine/nitric oxide.
RESULTS: Diethylamine/nitric oxide concentration dependently inhibited uterine contractions, and the effect was attenuated by previous treatment with oxyhemoglobin at mid gestation (
n = 8). The effects were negligible at late gestation (
n = 8). The relaxation of aortic rings by diethylamine/nitric oxide and its attenuation by previous treatment with oxyhemoglobin were similar at mid (
n = 6) and late (
n = 6) gestation. The sensitivity of aortic rings to diethylamine/nitric oxide is significantly higher than that of uterine rings. Oxyhemoglobin partly restored inhibited diethylamine/nitric oxide phenylephrine tension in aortic rings and had no effect on diethylamine/nitric oxide-inhibited uterine rings.
CONCLUSIONS: Uterine smooth muscle is less sensitive to nitric oxide than is aortic smooth muscle. Nitric oxide sensitivity of rat uterus but not aorta decreases toward term. (Am J Obstet Gynecol 1998;179:721-6.) |
| doi_str_mv | 10.1016/S0002-9378(98)70071-7 |
| format | Article |
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STUDY DESIGN: Rings of uterus and thoracic aorta without endothelium from Sprague-Dawley rats at mid and late gestation were used for isometric tension recording. The concentration-response curve for diethyl-amine/nitric oxide was studied in the presence or absence of oxyhemoglobin (10
–5 mol/L), or oxyhemoglobin was added after the response to diethylamine/nitric oxide.
RESULTS: Diethylamine/nitric oxide concentration dependently inhibited uterine contractions, and the effect was attenuated by previous treatment with oxyhemoglobin at mid gestation (
n = 8). The effects were negligible at late gestation (
n = 8). The relaxation of aortic rings by diethylamine/nitric oxide and its attenuation by previous treatment with oxyhemoglobin were similar at mid (
n = 6) and late (
n = 6) gestation. The sensitivity of aortic rings to diethylamine/nitric oxide is significantly higher than that of uterine rings. Oxyhemoglobin partly restored inhibited diethylamine/nitric oxide phenylephrine tension in aortic rings and had no effect on diethylamine/nitric oxide-inhibited uterine rings.
CONCLUSIONS: Uterine smooth muscle is less sensitive to nitric oxide than is aortic smooth muscle. Nitric oxide sensitivity of rat uterus but not aorta decreases toward term. (Am J Obstet Gynecol 1998;179:721-6.)</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/S0002-9378(98)70071-7</identifier><identifier>PMID: 9757978</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Mosby, Inc</publisher><subject>Animals ; Aorta ; Aorta - drug effects ; Biological and medical sciences ; Diethylamines - pharmacology ; Female ; Genital system. Reproduction ; In Vitro Techniques ; Medical sciences ; myometrium ; nitric oxide ; Nitric Oxide - pharmacology ; oxyhemoglobin ; Oxyhemoglobins - pharmacology ; Pharmacology. Drug treatments ; Pregnancy ; Pregnancy, Animal - physiology ; Rats ; Rats, Sprague-Dawley ; Uterine Contraction - drug effects ; Vasoconstriction - drug effects</subject><ispartof>American journal of obstetrics and gynecology, 1998-09, Vol.179 (3), p.721-726</ispartof><rights>1998 Mosby, Inc.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-808f845090a3d3b2c4481dfba74185cf8be0ac710324e235f421c3f02a25e6d43</citedby><cites>FETCH-LOGICAL-c455t-808f845090a3d3b2c4481dfba74185cf8be0ac710324e235f421c3f02a25e6d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0002-9378(98)70071-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2409319$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9757978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okawa, Toshiaki</creatorcontrib><creatorcontrib>Syal, Ashu S.</creatorcontrib><creatorcontrib>Vedernikov, Yuri P.</creatorcontrib><creatorcontrib>Saade, George R.</creatorcontrib><creatorcontrib>Chwalisz, Kristof</creatorcontrib><creatorcontrib>Garfield, Robert E.</creatorcontrib><title>The effects of nitric oxide on the contractility of isolated uterine and aortic rings from pregnant rats</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>OBJECTIVE: The object was to compare the effects of nitric oxide on isolated uterus and aorta of pregnant rats.
STUDY DESIGN: Rings of uterus and thoracic aorta without endothelium from Sprague-Dawley rats at mid and late gestation were used for isometric tension recording. The concentration-response curve for diethyl-amine/nitric oxide was studied in the presence or absence of oxyhemoglobin (10
–5 mol/L), or oxyhemoglobin was added after the response to diethylamine/nitric oxide.
RESULTS: Diethylamine/nitric oxide concentration dependently inhibited uterine contractions, and the effect was attenuated by previous treatment with oxyhemoglobin at mid gestation (
n = 8). The effects were negligible at late gestation (
n = 8). The relaxation of aortic rings by diethylamine/nitric oxide and its attenuation by previous treatment with oxyhemoglobin were similar at mid (
n = 6) and late (
n = 6) gestation. The sensitivity of aortic rings to diethylamine/nitric oxide is significantly higher than that of uterine rings. Oxyhemoglobin partly restored inhibited diethylamine/nitric oxide phenylephrine tension in aortic rings and had no effect on diethylamine/nitric oxide-inhibited uterine rings.
CONCLUSIONS: Uterine smooth muscle is less sensitive to nitric oxide than is aortic smooth muscle. Nitric oxide sensitivity of rat uterus but not aorta decreases toward term. (Am J Obstet Gynecol 1998;179:721-6.)</description><subject>Animals</subject><subject>Aorta</subject><subject>Aorta - drug effects</subject><subject>Biological and medical sciences</subject><subject>Diethylamines - pharmacology</subject><subject>Female</subject><subject>Genital system. Reproduction</subject><subject>In Vitro Techniques</subject><subject>Medical sciences</subject><subject>myometrium</subject><subject>nitric oxide</subject><subject>Nitric Oxide - pharmacology</subject><subject>oxyhemoglobin</subject><subject>Oxyhemoglobins - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Pregnancy</subject><subject>Pregnancy, Animal - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Uterine Contraction - drug effects</subject><subject>Vasoconstriction - drug effects</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rXCEUhqW0JJNpf0LARSjN4jZ-3auuSghtUwh00WQtjh4Tyx2dqlOaf18nM8w2Kzm8z6uHR4TOKflMCZ2ufhFC2KC5VJ-0upSESDrIN2hBiZbDpCb1Fi2OyCk6q_X3bmSanaATLUeppVqgp_snwBACuFZxDjjFVqLD-V_0gHPCrccup1asa3GO7XkHxZpn28DjbYMSE2CbPLa5tN7s82PFoeQ13hR4TDY1XGyr79G7YOcKHw7nEj18-3p_czvc_fz-4-b6bnBiHNugiApKjEQTyz1fMSeEoj6srBRUjS6oFRDrJCWcCWB8DIJRxwNhlo0wecGX6OP-3k3Jf7ZQm1nH6mCebYK8rUZyLaSaeAfHPehKrrVAMJsS17Y8G0rMzrB5MWx2-oxW5sVwry_R-eGB7WoN_tg6KO35xSG31dk5FJtcrEeMCaI51R37ssegy_gboZjqIiQHPpb-Gcbn-Moi_wEfE5hl</recordid><startdate>19980901</startdate><enddate>19980901</enddate><creator>Okawa, Toshiaki</creator><creator>Syal, Ashu S.</creator><creator>Vedernikov, Yuri P.</creator><creator>Saade, George R.</creator><creator>Chwalisz, Kristof</creator><creator>Garfield, Robert E.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980901</creationdate><title>The effects of nitric oxide on the contractility of isolated uterine and aortic rings from pregnant rats</title><author>Okawa, Toshiaki ; Syal, Ashu S. ; Vedernikov, Yuri P. ; Saade, George R. ; Chwalisz, Kristof ; Garfield, Robert E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-808f845090a3d3b2c4481dfba74185cf8be0ac710324e235f421c3f02a25e6d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Aorta</topic><topic>Aorta - drug effects</topic><topic>Biological and medical sciences</topic><topic>Diethylamines - pharmacology</topic><topic>Female</topic><topic>Genital system. Reproduction</topic><topic>In Vitro Techniques</topic><topic>Medical sciences</topic><topic>myometrium</topic><topic>nitric oxide</topic><topic>Nitric Oxide - pharmacology</topic><topic>oxyhemoglobin</topic><topic>Oxyhemoglobins - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pregnancy</topic><topic>Pregnancy, Animal - physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Uterine Contraction - drug effects</topic><topic>Vasoconstriction - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okawa, Toshiaki</creatorcontrib><creatorcontrib>Syal, Ashu S.</creatorcontrib><creatorcontrib>Vedernikov, Yuri P.</creatorcontrib><creatorcontrib>Saade, George R.</creatorcontrib><creatorcontrib>Chwalisz, Kristof</creatorcontrib><creatorcontrib>Garfield, Robert E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okawa, Toshiaki</au><au>Syal, Ashu S.</au><au>Vedernikov, Yuri P.</au><au>Saade, George R.</au><au>Chwalisz, Kristof</au><au>Garfield, Robert E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of nitric oxide on the contractility of isolated uterine and aortic rings from pregnant rats</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1998-09-01</date><risdate>1998</risdate><volume>179</volume><issue>3</issue><spage>721</spage><epage>726</epage><pages>721-726</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>OBJECTIVE: The object was to compare the effects of nitric oxide on isolated uterus and aorta of pregnant rats.
STUDY DESIGN: Rings of uterus and thoracic aorta without endothelium from Sprague-Dawley rats at mid and late gestation were used for isometric tension recording. The concentration-response curve for diethyl-amine/nitric oxide was studied in the presence or absence of oxyhemoglobin (10
–5 mol/L), or oxyhemoglobin was added after the response to diethylamine/nitric oxide.
RESULTS: Diethylamine/nitric oxide concentration dependently inhibited uterine contractions, and the effect was attenuated by previous treatment with oxyhemoglobin at mid gestation (
n = 8). The effects were negligible at late gestation (
n = 8). The relaxation of aortic rings by diethylamine/nitric oxide and its attenuation by previous treatment with oxyhemoglobin were similar at mid (
n = 6) and late (
n = 6) gestation. The sensitivity of aortic rings to diethylamine/nitric oxide is significantly higher than that of uterine rings. Oxyhemoglobin partly restored inhibited diethylamine/nitric oxide phenylephrine tension in aortic rings and had no effect on diethylamine/nitric oxide-inhibited uterine rings.
CONCLUSIONS: Uterine smooth muscle is less sensitive to nitric oxide than is aortic smooth muscle. Nitric oxide sensitivity of rat uterus but not aorta decreases toward term. (Am J Obstet Gynecol 1998;179:721-6.)</abstract><cop>Philadelphia, PA</cop><pub>Mosby, Inc</pub><pmid>9757978</pmid><doi>10.1016/S0002-9378(98)70071-7</doi><tpages>6</tpages></addata></record> |
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| ispartof | American journal of obstetrics and gynecology, 1998-09, Vol.179 (3), p.721-726 |
| issn | 0002-9378 1097-6868 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73947863 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Aorta Aorta - drug effects Biological and medical sciences Diethylamines - pharmacology Female Genital system. Reproduction In Vitro Techniques Medical sciences myometrium nitric oxide Nitric Oxide - pharmacology oxyhemoglobin Oxyhemoglobins - pharmacology Pharmacology. Drug treatments Pregnancy Pregnancy, Animal - physiology Rats Rats, Sprague-Dawley Uterine Contraction - drug effects Vasoconstriction - drug effects |
| title | The effects of nitric oxide on the contractility of isolated uterine and aortic rings from pregnant rats |
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