Soluble IL-1 receptor type I binds to human dermal fibroblasts and induces calcium flux

Soluble cytokine receptors appear to modify ligand concentrations by stabilizing ligands or by specifically inhibiting interactions of ligands with their membrane-bound receptors. Here we describe a new function of the soluble interleukin-1 receptor type I (IL-1sR I). This receptor induced a transie...

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Veröffentlicht in:	FEBS letters 1998-09, Vol.434 (3), p.283-288
Hauptverfasser:	Spörri, Bernhard, Wiesmann, Ueli N., Ochsenbein, Regula M., Loetscher, Marcel, Waelti, Ernst R., Lottaz, Daniel, Bickel, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	BK, bradykinin Calcium Calcium - metabolism Cells, Cultured Fibroblast Fibroblasts - metabolism Humans IL-1, interleukin-1 IL-1R I, type I IL-1 receptor IL-1R-AcP, IL-1R accessory protein IL-1ra, interleukin-1 receptor antagonist IL-1sR I, soluble IL-1 receptor type I IL-6Rα, soluble IL-6 receptor α chain Interleukin-1 Interleukin-1 - metabolism Interleukin-6 - genetics Interleukin-8 - genetics Ion Transport Protein Binding Receptors, Interleukin-1 - metabolism RNA, Messenger - genetics Signal transduction Skin - cytology Skin - metabolism Soluble receptor Up-Regulation
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