Interleukin-18: Perspectives on the Newest Interleukin
Just over two years ago the newest member of the interleukin family of cytokines, IL-18, was molecularly cloned. IL-18 was originally identified as a result of its ability to induce interferon gamma production, however with the advent of its cloning and the production of recombinant protein a number...
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| Veröffentlicht in: | Cytokine & growth factor reviews 1998-06, Vol.9 (2), p.109-116 |
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| creator | Gillespie, Matthew T Horwood, Nicole J |
| description | Just over two years ago the newest member of the interleukin family of cytokines, IL-18, was molecularly cloned. IL-18 was originally identified as a result of its ability to induce interferon gamma production, however with the advent of its cloning and the production of recombinant protein a number of other biological actions have since been identified. Recently the receptor for IL-18 was also characterised. Due to the structural and biological properties shared between IL-18 and IL-1 and their respective receptors, questions relating to IL-18 activities are being answered at a rapid pace. This article addresses the biology of IL-18 in both disease and non-disease states. |
| doi_str_mv | 10.1016/S1359-6101(98)00004-5 |
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IL-18 was originally identified as a result of its ability to induce interferon gamma production, however with the advent of its cloning and the production of recombinant protein a number of other biological actions have since been identified. Recently the receptor for IL-18 was also characterised. Due to the structural and biological properties shared between IL-18 and IL-1 and their respective receptors, questions relating to IL-18 activities are being answered at a rapid pace. This article addresses the biology of IL-18 in both disease and non-disease states.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Autoimmunity</subject><subject>Cytokines</subject><subject>Diabetes Mellitus, Type 1 - immunology</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>IGI</subject><subject>IL-18</subject><subject>Interferon gamma</subject><subject>Interleukin-1 - genetics</subject><subject>Interleukin-1 - physiology</subject><subject>Interleukin-18 - genetics</subject><subject>Interleukin-18 - physiology</subject><subject>Interleukin-18 Receptor alpha Subunit</subject><subject>Molecular Sequence Data</subject><subject>Neoplasms, Experimental - immunology</subject><subject>Osteoclasts - cytology</subject><subject>Receptors, Interleukin - physiology</subject><subject>Receptors, Interleukin-18</subject><subject>T-cells</subject><subject>T-Lymphocytes - immunology</subject><issn>1359-6101</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRb0AlVL4hEpZIVgE7Dh-sUGo4lGpAiRgbaXxWBjSpNhJEX-P01YVu3phj2bunWsdhMYEXxJM-NUroUylPNbnSl7gePKUHaDhrn2EjkP47PuU4QEaKMFygdkQ8Wndgq-g-3J1SuR18gI-LKFs3QpC0tRJ-wHJE_xAaJN_0hN0aIsqwOn2HaH3-7u3yWM6e36YTm5naUkVaVNFBRc5zxmnlhso5kA50HhTJnNqTAYYpMz53GZWECIVlqUyRcaEkqCspSN0ttm79M13Fz-hFy6UUFVFDU0XtKAxImN0r5AIwjIuWRSyjbD0TQgerF56tyj8ryZY9zD1GqbuqWkl9Rqm7n3jbUA3X4DZubYk4_xmM4eIY-XA61A6qEswzkec2jRuT8IfY-iEOA</recordid><startdate>19980601</startdate><enddate>19980601</enddate><creator>Gillespie, Matthew T</creator><creator>Horwood, Nicole J</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19980601</creationdate><title>Interleukin-18: Perspectives on the Newest Interleukin</title><author>Gillespie, Matthew T ; Horwood, Nicole J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-93767464563f6deabe36e3be335843dd2e0e8846bf2f7118908c9da25798e9ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Autoimmunity</topic><topic>Cytokines</topic><topic>Diabetes Mellitus, Type 1 - immunology</topic><topic>Gene Expression</topic><topic>Humans</topic><topic>IGI</topic><topic>IL-18</topic><topic>Interferon gamma</topic><topic>Interleukin-1 - genetics</topic><topic>Interleukin-1 - physiology</topic><topic>Interleukin-18 - genetics</topic><topic>Interleukin-18 - physiology</topic><topic>Interleukin-18 Receptor alpha Subunit</topic><topic>Molecular Sequence Data</topic><topic>Neoplasms, Experimental - immunology</topic><topic>Osteoclasts - cytology</topic><topic>Receptors, Interleukin - physiology</topic><topic>Receptors, Interleukin-18</topic><topic>T-cells</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gillespie, Matthew T</creatorcontrib><creatorcontrib>Horwood, Nicole J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cytokine & growth factor reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gillespie, Matthew T</au><au>Horwood, Nicole J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-18: Perspectives on the Newest Interleukin</atitle><jtitle>Cytokine & growth factor reviews</jtitle><addtitle>Cytokine Growth Factor Rev</addtitle><date>1998-06-01</date><risdate>1998</risdate><volume>9</volume><issue>2</issue><spage>109</spage><epage>116</epage><pages>109-116</pages><issn>1359-6101</issn><abstract>Just over two years ago the newest member of the interleukin family of cytokines, IL-18, was molecularly cloned. 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| fulltext | fulltext |
| identifier | ISSN: 1359-6101 |
| ispartof | Cytokine & growth factor reviews, 1998-06, Vol.9 (2), p.109-116 |
| issn | 1359-6101 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Amino Acid Sequence Animals Autoimmunity Cytokines Diabetes Mellitus, Type 1 - immunology Gene Expression Humans IGI IL-18 Interferon gamma Interleukin-1 - genetics Interleukin-1 - physiology Interleukin-18 - genetics Interleukin-18 - physiology Interleukin-18 Receptor alpha Subunit Molecular Sequence Data Neoplasms, Experimental - immunology Osteoclasts - cytology Receptors, Interleukin - physiology Receptors, Interleukin-18 T-cells T-Lymphocytes - immunology |
| title | Interleukin-18: Perspectives on the Newest Interleukin |
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