Helper T Cell Differentiation Is Controlled by the Cell Cycle

Helper T (Th) cell differentiation is highly regulated by cytokines but initiated by mitogens. By examining gene expression in discrete generations of dividing cells, we have delineated the relationship between proliferation and differentiation. Initial expression of IL-2 is cell cycle-independent,...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 1998-08, Vol.9 (2), p.229-237
Hauptverfasser:	Bird, Jennifer J, Brown, Daniel R, Mullen, Alan C, Moskowitz, Naomi H, Mahowald, Michael A, Sider, Jenny R, Gajewski, Thomas F, Wang, Chyung-Ru, Reiner, Steven L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle - physiology Cell Differentiation - genetics Cell Lineage - genetics Cytokines - biosynthesis Cytokines - genetics Cytokines - physiology Gene Expression - genetics Immunologic Memory - genetics Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Transgenic Signal Transduction - genetics T-Lymphocytes, Helper-Inducer - cytology T-Lymphocytes, Helper-Inducer - metabolism
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