A community based study of vitamin A and vitamin E status of adolescent girls living in the Shire valley, Southern Malawi
To assess vitamin A and E status and anaemia in non-pregnant Malawian adolescent girls. A cross-sectional study in rural village communities in the Shire Valley, Southern Malawi. Adolescent girls, n = 118, aged between 10 and 19 y, 112 of whom were unmarried. Socio-demographic information was collec...
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Veröffentlicht in: | European journal of clinical nutrition 1998-09, Vol.52 (9), p.637-642 |
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creator | FAZIO-TIRROZZO, G BRABIN, L BRABIN, B AGBAJE, O HARPER, G BROADHEAD, R |
description | To assess vitamin A and E status and anaemia in non-pregnant Malawian adolescent girls.
A cross-sectional study in rural village communities in the Shire Valley, Southern Malawi.
Adolescent girls, n = 118, aged between 10 and 19 y, 112 of whom were unmarried.
Socio-demographic information was collected by questionnaire, heights and weights were measured. Vitamin A was assessed by the Modified Relative Dose Response (MRDR) test, in addition to serum retinol values. Blood samples were collected 4-5 h after administration of 3,4-didehydroretinyl acetate. Retinol and alpha-tocopherol levels were measured by HPLC. Serum retinol results for non-pregnant girls were compared with values for 43 adolescent pregnant girls which were available from a previous study.
26.6% of non-pregnant girls had serum retinol values < 0.70 micromol/L; 40.2% had an MRDR ratio > 0.060. In 59.3%, serum tocopherol levels were < 11.5 micromol/L and the tocopherol/cholesterol ratio was < 2.2 in 23.9%. 11.3% had a haemoglobin > or = 12 g/dl. Vitamin A levels were significantly related to age, and younger girls were more likely to be deficient. Significant correlations were found between serum retinol, MRDR values and serum tocopherol. Girls with a low body mass index for age had tocopherol cholesterol ratios < 2.2. Low serum retinol values occurred significantly more often in stunted girls (P=0.01). Serum retinol values of adolescent pregnant girls were significantly lower than those of non-pregnant adolescents (P=0.002).
Vitamin A and E deficiency and anaemia were common in adolescent non-pregnant girls, and thought to partly result from increased growth requirements. Girls who become pregnant at an early age are at risk of depletion of their nutritional reserves. Measures to reduce nutritional deficiencies before the first pregnancy are needed. |
doi_str_mv | 10.1038/sj.ejcn.1600622 |
format | Article |
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A cross-sectional study in rural village communities in the Shire Valley, Southern Malawi.
Adolescent girls, n = 118, aged between 10 and 19 y, 112 of whom were unmarried.
Socio-demographic information was collected by questionnaire, heights and weights were measured. Vitamin A was assessed by the Modified Relative Dose Response (MRDR) test, in addition to serum retinol values. Blood samples were collected 4-5 h after administration of 3,4-didehydroretinyl acetate. Retinol and alpha-tocopherol levels were measured by HPLC. Serum retinol results for non-pregnant girls were compared with values for 43 adolescent pregnant girls which were available from a previous study.
26.6% of non-pregnant girls had serum retinol values < 0.70 micromol/L; 40.2% had an MRDR ratio > 0.060. In 59.3%, serum tocopherol levels were < 11.5 micromol/L and the tocopherol/cholesterol ratio was < 2.2 in 23.9%. 11.3% had a haemoglobin > or = 12 g/dl. Vitamin A levels were significantly related to age, and younger girls were more likely to be deficient. Significant correlations were found between serum retinol, MRDR values and serum tocopherol. Girls with a low body mass index for age had tocopherol cholesterol ratios < 2.2. Low serum retinol values occurred significantly more often in stunted girls (P=0.01). Serum retinol values of adolescent pregnant girls were significantly lower than those of non-pregnant adolescents (P=0.002).
Vitamin A and E deficiency and anaemia were common in adolescent non-pregnant girls, and thought to partly result from increased growth requirements. Girls who become pregnant at an early age are at risk of depletion of their nutritional reserves. Measures to reduce nutritional deficiencies before the first pregnancy are needed.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/sj.ejcn.1600622</identifier><identifier>PMID: 9756119</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing</publisher><subject>Acetic acid ; Adolescent ; Adolescents ; Adult ; Age ; Anemia ; Anemia - epidemiology ; Anemias. Hemoglobinopathies ; Biological and medical sciences ; Body Mass Index ; Body size ; Child ; Cholesterol ; Cholesterol - blood ; Cross-Sectional Studies ; Depletion ; Diseases of red blood cells ; Female ; Girls ; Hematologic and hematopoietic diseases ; Hemoglobin ; High-performance liquid chromatography ; Humans ; Liquid chromatography ; Malawi - epidemiology ; Medical sciences ; Nutrient deficiency ; Nutrient requirements ; Nutrition ; Nutritional Status ; Pregnancy ; Reference Values ; Retinene ; Teenagers ; Tocopherol ; Valleys ; Vitamin A ; Vitamin A - blood ; Vitamin A Deficiency - epidemiology ; Vitamin E ; Vitamin E - blood ; Vitamin E Deficiency - epidemiology</subject><ispartof>European journal of clinical nutrition, 1998-09, Vol.52 (9), p.637-642</ispartof><rights>1998 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Sep 1998</rights><rights>Macmillan Publishers Limited 1998.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-6cbe3001ea4272afab06142d7c4ca23cb0809212ed63b17cf665f1efcb3e372f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2370823$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9756119$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FAZIO-TIRROZZO, G</creatorcontrib><creatorcontrib>BRABIN, L</creatorcontrib><creatorcontrib>BRABIN, B</creatorcontrib><creatorcontrib>AGBAJE, O</creatorcontrib><creatorcontrib>HARPER, G</creatorcontrib><creatorcontrib>BROADHEAD, R</creatorcontrib><title>A community based study of vitamin A and vitamin E status of adolescent girls living in the Shire valley, Southern Malawi</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><description>To assess vitamin A and E status and anaemia in non-pregnant Malawian adolescent girls.
A cross-sectional study in rural village communities in the Shire Valley, Southern Malawi.
Adolescent girls, n = 118, aged between 10 and 19 y, 112 of whom were unmarried.
Socio-demographic information was collected by questionnaire, heights and weights were measured. Vitamin A was assessed by the Modified Relative Dose Response (MRDR) test, in addition to serum retinol values. Blood samples were collected 4-5 h after administration of 3,4-didehydroretinyl acetate. Retinol and alpha-tocopherol levels were measured by HPLC. Serum retinol results for non-pregnant girls were compared with values for 43 adolescent pregnant girls which were available from a previous study.
26.6% of non-pregnant girls had serum retinol values < 0.70 micromol/L; 40.2% had an MRDR ratio > 0.060. In 59.3%, serum tocopherol levels were < 11.5 micromol/L and the tocopherol/cholesterol ratio was < 2.2 in 23.9%. 11.3% had a haemoglobin > or = 12 g/dl. Vitamin A levels were significantly related to age, and younger girls were more likely to be deficient. Significant correlations were found between serum retinol, MRDR values and serum tocopherol. Girls with a low body mass index for age had tocopherol cholesterol ratios < 2.2. Low serum retinol values occurred significantly more often in stunted girls (P=0.01). Serum retinol values of adolescent pregnant girls were significantly lower than those of non-pregnant adolescents (P=0.002).
Vitamin A and E deficiency and anaemia were common in adolescent non-pregnant girls, and thought to partly result from increased growth requirements. Girls who become pregnant at an early age are at risk of depletion of their nutritional reserves. Measures to reduce nutritional deficiencies before the first pregnancy are needed.</description><subject>Acetic acid</subject><subject>Adolescent</subject><subject>Adolescents</subject><subject>Adult</subject><subject>Age</subject><subject>Anemia</subject><subject>Anemia - epidemiology</subject><subject>Anemias. Hemoglobinopathies</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Body size</subject><subject>Child</subject><subject>Cholesterol</subject><subject>Cholesterol - blood</subject><subject>Cross-Sectional Studies</subject><subject>Depletion</subject><subject>Diseases of red blood cells</subject><subject>Female</subject><subject>Girls</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hemoglobin</subject><subject>High-performance liquid chromatography</subject><subject>Humans</subject><subject>Liquid chromatography</subject><subject>Malawi - epidemiology</subject><subject>Medical sciences</subject><subject>Nutrient deficiency</subject><subject>Nutrient requirements</subject><subject>Nutrition</subject><subject>Nutritional Status</subject><subject>Pregnancy</subject><subject>Reference Values</subject><subject>Retinene</subject><subject>Teenagers</subject><subject>Tocopherol</subject><subject>Valleys</subject><subject>Vitamin A</subject><subject>Vitamin A - blood</subject><subject>Vitamin A Deficiency - epidemiology</subject><subject>Vitamin E</subject><subject>Vitamin E - blood</subject><subject>Vitamin E Deficiency - epidemiology</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10U1v3CAQBmAUtUq3Sc49VUJNlVO94cMG-7iK0qZSqhzSntEYQ4KFcQr2Vv73ZRVrD5V6QjAPo4EXoQ-UbCnh9XXqt6bXYUsFIYKxE7ShpRRFJUryBm1IU5UFJ0S-Q-9T6gnJRclO0WkjK0Fps0HLDutxGObgpgW3kEyH0zR3Cx4t3rsJBhfwDkPojrvbDGCa00FAN3qTtAkTfnLRJ-zd3oUnnNn0bPDjs4sG78F7s3zBj-OcD2PAP8DDH3eO3lrwyVys6xn69fX2581dcf_w7fvN7r7QJZVTIXRr8guogZJJBhZaImjJOqlLDYzrltSkYZSZTvCWSm2FqCw1VrfccMksP0NXr31f4vh7NmlSg8sjew_BjHNSkjdcVERmePkP7Mc5hjybYqJkgjU1rbP69F9FG1HlHycZXb8iHceUorHqJboB4qIoUYfcVOrVITe15pZvfFzbzu1guqNfg8r1z2sdkgZvIwTt0pExLknNOP8LtA2g9w</recordid><startdate>19980901</startdate><enddate>19980901</enddate><creator>FAZIO-TIRROZZO, G</creator><creator>BRABIN, L</creator><creator>BRABIN, B</creator><creator>AGBAJE, O</creator><creator>HARPER, G</creator><creator>BROADHEAD, R</creator><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>19980901</creationdate><title>A community based study of vitamin A and vitamin E status of adolescent girls living in the Shire valley, Southern Malawi</title><author>FAZIO-TIRROZZO, G ; BRABIN, L ; BRABIN, B ; AGBAJE, O ; HARPER, G ; BROADHEAD, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-6cbe3001ea4272afab06142d7c4ca23cb0809212ed63b17cf665f1efcb3e372f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Acetic acid</topic><topic>Adolescent</topic><topic>Adolescents</topic><topic>Adult</topic><topic>Age</topic><topic>Anemia</topic><topic>Anemia - epidemiology</topic><topic>Anemias. Hemoglobinopathies</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Body size</topic><topic>Child</topic><topic>Cholesterol</topic><topic>Cholesterol - blood</topic><topic>Cross-Sectional Studies</topic><topic>Depletion</topic><topic>Diseases of red blood cells</topic><topic>Female</topic><topic>Girls</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hemoglobin</topic><topic>High-performance liquid chromatography</topic><topic>Humans</topic><topic>Liquid chromatography</topic><topic>Malawi - epidemiology</topic><topic>Medical sciences</topic><topic>Nutrient deficiency</topic><topic>Nutrient requirements</topic><topic>Nutrition</topic><topic>Nutritional Status</topic><topic>Pregnancy</topic><topic>Reference Values</topic><topic>Retinene</topic><topic>Teenagers</topic><topic>Tocopherol</topic><topic>Valleys</topic><topic>Vitamin A</topic><topic>Vitamin A - blood</topic><topic>Vitamin A Deficiency - epidemiology</topic><topic>Vitamin E</topic><topic>Vitamin E - blood</topic><topic>Vitamin E Deficiency - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FAZIO-TIRROZZO, G</creatorcontrib><creatorcontrib>BRABIN, L</creatorcontrib><creatorcontrib>BRABIN, B</creatorcontrib><creatorcontrib>AGBAJE, O</creatorcontrib><creatorcontrib>HARPER, G</creatorcontrib><creatorcontrib>BROADHEAD, R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FAZIO-TIRROZZO, G</au><au>BRABIN, L</au><au>BRABIN, B</au><au>AGBAJE, O</au><au>HARPER, G</au><au>BROADHEAD, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A community based study of vitamin A and vitamin E status of adolescent girls living in the Shire valley, Southern Malawi</atitle><jtitle>European journal of clinical nutrition</jtitle><addtitle>Eur J Clin Nutr</addtitle><date>1998-09-01</date><risdate>1998</risdate><volume>52</volume><issue>9</issue><spage>637</spage><epage>642</epage><pages>637-642</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract>To assess vitamin A and E status and anaemia in non-pregnant Malawian adolescent girls.
A cross-sectional study in rural village communities in the Shire Valley, Southern Malawi.
Adolescent girls, n = 118, aged between 10 and 19 y, 112 of whom were unmarried.
Socio-demographic information was collected by questionnaire, heights and weights were measured. Vitamin A was assessed by the Modified Relative Dose Response (MRDR) test, in addition to serum retinol values. Blood samples were collected 4-5 h after administration of 3,4-didehydroretinyl acetate. Retinol and alpha-tocopherol levels were measured by HPLC. Serum retinol results for non-pregnant girls were compared with values for 43 adolescent pregnant girls which were available from a previous study.
26.6% of non-pregnant girls had serum retinol values < 0.70 micromol/L; 40.2% had an MRDR ratio > 0.060. In 59.3%, serum tocopherol levels were < 11.5 micromol/L and the tocopherol/cholesterol ratio was < 2.2 in 23.9%. 11.3% had a haemoglobin > or = 12 g/dl. Vitamin A levels were significantly related to age, and younger girls were more likely to be deficient. Significant correlations were found between serum retinol, MRDR values and serum tocopherol. Girls with a low body mass index for age had tocopherol cholesterol ratios < 2.2. Low serum retinol values occurred significantly more often in stunted girls (P=0.01). Serum retinol values of adolescent pregnant girls were significantly lower than those of non-pregnant adolescents (P=0.002).
Vitamin A and E deficiency and anaemia were common in adolescent non-pregnant girls, and thought to partly result from increased growth requirements. Girls who become pregnant at an early age are at risk of depletion of their nutritional reserves. Measures to reduce nutritional deficiencies before the first pregnancy are needed.</abstract><cop>Basingstoke</cop><pub>Nature Publishing</pub><pmid>9756119</pmid><doi>10.1038/sj.ejcn.1600622</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; Nature; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
subjects | Acetic acid Adolescent Adolescents Adult Age Anemia Anemia - epidemiology Anemias. Hemoglobinopathies Biological and medical sciences Body Mass Index Body size Child Cholesterol Cholesterol - blood Cross-Sectional Studies Depletion Diseases of red blood cells Female Girls Hematologic and hematopoietic diseases Hemoglobin High-performance liquid chromatography Humans Liquid chromatography Malawi - epidemiology Medical sciences Nutrient deficiency Nutrient requirements Nutrition Nutritional Status Pregnancy Reference Values Retinene Teenagers Tocopherol Valleys Vitamin A Vitamin A - blood Vitamin A Deficiency - epidemiology Vitamin E Vitamin E - blood Vitamin E Deficiency - epidemiology |
title | A community based study of vitamin A and vitamin E status of adolescent girls living in the Shire valley, Southern Malawi |
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