The brain-gut-skin triangle: New peptides
New data on tachykinins and bombesins are displayed and the present situation of research on the novel amphibian skin peptides sauvagine and dermorphin is illustrated. The potent stimulant effect of sauvagine on ACTH and β-endorphin release has been confirmed both in vivo and on columns of isolated...
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| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1981, Vol.2, p.7-16 |
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| container_title | Peptides (New York, N.Y. : 1980) |
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| creator | Erspamer, Vittorio Melchiorri, Pietro Broccardo, Maria Erspamer, Giuliana Falconieri Falaschi, Paolo Improta, Giovanna Negri, Lucia Renda, Tindaro |
| description | New data on tachykinins and bombesins are displayed and the present situation of research on the novel amphibian skin peptides sauvagine and dermorphin is illustrated. The potent stimulant effect of sauvagine on ACTH and β-endorphin release has been confirmed both in vivo and on columns of isolated and dispersed rat pituitary cells, and similarly the potent inhibitory effect on PRL and GH release, both in the rat and man. Particular emphasis is laid on the occurrence of sauvagine-like immunoreactivity in fish urophysis and in amphibian nervous structures, including the retina. It is suggested that the long-searched corticotropin releasing factor and PRL release-inhibiting factor may be a sauvagine-like peptide. Dermorphin, in its turn, has been found to cause, by intracerebroventricular injection, not only analgesia and catalepsy, but also conspicuous EEG and behavioral changes in the rabbit and chick, as well as a sharp reduction in gastric emptying time and gastric acid output in the rat, together with marked stimulation of PRL release. |
| doi_str_mv | 10.1016/0196-9781(81)90003-6 |
| format | Article |
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The potent stimulant effect of sauvagine on ACTH and β-endorphin release has been confirmed both in vivo and on columns of isolated and dispersed rat pituitary cells, and similarly the potent inhibitory effect on PRL and GH release, both in the rat and man. Particular emphasis is laid on the occurrence of sauvagine-like immunoreactivity in fish urophysis and in amphibian nervous structures, including the retina. It is suggested that the long-searched corticotropin releasing factor and PRL release-inhibiting factor may be a sauvagine-like peptide. Dermorphin, in its turn, has been found to cause, by intracerebroventricular injection, not only analgesia and catalepsy, but also conspicuous EEG and behavioral changes in the rabbit and chick, as well as a sharp reduction in gastric emptying time and gastric acid output in the rat, together with marked stimulation of PRL release.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/0196-9781(81)90003-6</identifier><identifier>PMID: 6178095</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adrenocorticotropic Hormone - metabolism ; Amino Acid Sequence ; Amphibian Proteins ; Analgesia ; Animals ; Behavior, Animal - physiology ; beta-Endorphin ; Bombesin - metabolism ; Bombesins ; Brain - metabolism ; Brain-gut-skin peptide triangle ; Dermorphins ; Digestive System - metabolism ; Endorphins - metabolism ; Gastric Acid - metabolism ; Gastric Emptying ; Hemodynamics ; Histocytochemistry ; Humans ; Muscle Contraction ; Muscle, Smooth - physiology ; Oligopeptides - physiology ; Opioid Peptides ; Peptide Hormones ; Peptides - physiology ; Pituitary Hormones, Anterior - metabolism ; Prolactin - metabolism ; Protein Conformation ; Sauvagine ; Sauvagine-like immunoreactivity ; Skin - metabolism ; Substance P - physiology ; Tachykinins</subject><ispartof>Peptides (New York, N.Y. : 1980), 1981, Vol.2, p.7-16</ispartof><rights>1982</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-1983156f24c9a0222e27a8d469b49e74bc892af27930d353d4d269c2e2a19c0a3</citedby><cites>FETCH-LOGICAL-c357t-1983156f24c9a0222e27a8d469b49e74bc892af27930d353d4d269c2e2a19c0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0196978181900036$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27902,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6178095$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Erspamer, Vittorio</creatorcontrib><creatorcontrib>Melchiorri, Pietro</creatorcontrib><creatorcontrib>Broccardo, Maria</creatorcontrib><creatorcontrib>Erspamer, Giuliana Falconieri</creatorcontrib><creatorcontrib>Falaschi, Paolo</creatorcontrib><creatorcontrib>Improta, Giovanna</creatorcontrib><creatorcontrib>Negri, Lucia</creatorcontrib><creatorcontrib>Renda, Tindaro</creatorcontrib><title>The brain-gut-skin triangle: New peptides</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>New data on tachykinins and bombesins are displayed and the present situation of research on the novel amphibian skin peptides sauvagine and dermorphin is illustrated. The potent stimulant effect of sauvagine on ACTH and β-endorphin release has been confirmed both in vivo and on columns of isolated and dispersed rat pituitary cells, and similarly the potent inhibitory effect on PRL and GH release, both in the rat and man. Particular emphasis is laid on the occurrence of sauvagine-like immunoreactivity in fish urophysis and in amphibian nervous structures, including the retina. It is suggested that the long-searched corticotropin releasing factor and PRL release-inhibiting factor may be a sauvagine-like peptide. Dermorphin, in its turn, has been found to cause, by intracerebroventricular injection, not only analgesia and catalepsy, but also conspicuous EEG and behavioral changes in the rabbit and chick, as well as a sharp reduction in gastric emptying time and gastric acid output in the rat, together with marked stimulation of PRL release.</description><subject>Adrenocorticotropic Hormone - metabolism</subject><subject>Amino Acid Sequence</subject><subject>Amphibian Proteins</subject><subject>Analgesia</subject><subject>Animals</subject><subject>Behavior, Animal - physiology</subject><subject>beta-Endorphin</subject><subject>Bombesin - metabolism</subject><subject>Bombesins</subject><subject>Brain - metabolism</subject><subject>Brain-gut-skin peptide triangle</subject><subject>Dermorphins</subject><subject>Digestive System - metabolism</subject><subject>Endorphins - metabolism</subject><subject>Gastric Acid - metabolism</subject><subject>Gastric Emptying</subject><subject>Hemodynamics</subject><subject>Histocytochemistry</subject><subject>Humans</subject><subject>Muscle Contraction</subject><subject>Muscle, Smooth - physiology</subject><subject>Oligopeptides - physiology</subject><subject>Opioid Peptides</subject><subject>Peptide Hormones</subject><subject>Peptides - physiology</subject><subject>Pituitary Hormones, Anterior - metabolism</subject><subject>Prolactin - metabolism</subject><subject>Protein Conformation</subject><subject>Sauvagine</subject><subject>Sauvagine-like immunoreactivity</subject><subject>Skin - metabolism</subject><subject>Substance P - physiology</subject><subject>Tachykinins</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtPwzAQhC0EKqXwD0DKCdGDwa84MQckVPGSKriUs-XYm2JIk2AnIP49Ka16RFppD_vNrGYQOqXkkhIqrwhVEqsspxc5nSpCCMdyD41pnnGcUqn20XiHHKKjGN8HRgiVj9BI0iwnKh2j6eINkiIYX-Nl3-H44eukC97Uywquk2f4TlpoO-8gHqOD0lQRTrZ7gl7v7xazRzx_eXia3c6x5WnWYapyTlNZMmGVIYwxYJnJnZCqEAoyUdhcMVOyTHHieMqdcEwqO2CGKksMn6DzjW8bms8eYqdXPlqoKlND00edccVTpsQAig1oQxNjgFK3wa9M-NGU6HVDeh1fr-PrYf4a0nKQnW39-2IFbifaVjLcbzZ3GEJ-eQg6Wg-1BecD2E67xv__4BegGHKN</recordid><startdate>1981</startdate><enddate>1981</enddate><creator>Erspamer, Vittorio</creator><creator>Melchiorri, Pietro</creator><creator>Broccardo, Maria</creator><creator>Erspamer, Giuliana Falconieri</creator><creator>Falaschi, Paolo</creator><creator>Improta, Giovanna</creator><creator>Negri, Lucia</creator><creator>Renda, Tindaro</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1981</creationdate><title>The brain-gut-skin triangle: New peptides</title><author>Erspamer, Vittorio ; Melchiorri, Pietro ; Broccardo, Maria ; Erspamer, Giuliana Falconieri ; Falaschi, Paolo ; Improta, Giovanna ; Negri, Lucia ; Renda, Tindaro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-1983156f24c9a0222e27a8d469b49e74bc892af27930d353d4d269c2e2a19c0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Adrenocorticotropic Hormone - metabolism</topic><topic>Amino Acid Sequence</topic><topic>Amphibian Proteins</topic><topic>Analgesia</topic><topic>Animals</topic><topic>Behavior, Animal - physiology</topic><topic>beta-Endorphin</topic><topic>Bombesin - metabolism</topic><topic>Bombesins</topic><topic>Brain - metabolism</topic><topic>Brain-gut-skin peptide triangle</topic><topic>Dermorphins</topic><topic>Digestive System - metabolism</topic><topic>Endorphins - metabolism</topic><topic>Gastric Acid - metabolism</topic><topic>Gastric Emptying</topic><topic>Hemodynamics</topic><topic>Histocytochemistry</topic><topic>Humans</topic><topic>Muscle Contraction</topic><topic>Muscle, Smooth - physiology</topic><topic>Oligopeptides - physiology</topic><topic>Opioid Peptides</topic><topic>Peptide Hormones</topic><topic>Peptides - physiology</topic><topic>Pituitary Hormones, Anterior - metabolism</topic><topic>Prolactin - metabolism</topic><topic>Protein Conformation</topic><topic>Sauvagine</topic><topic>Sauvagine-like immunoreactivity</topic><topic>Skin - metabolism</topic><topic>Substance P - physiology</topic><topic>Tachykinins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Erspamer, Vittorio</creatorcontrib><creatorcontrib>Melchiorri, Pietro</creatorcontrib><creatorcontrib>Broccardo, Maria</creatorcontrib><creatorcontrib>Erspamer, Giuliana Falconieri</creatorcontrib><creatorcontrib>Falaschi, Paolo</creatorcontrib><creatorcontrib>Improta, Giovanna</creatorcontrib><creatorcontrib>Negri, Lucia</creatorcontrib><creatorcontrib>Renda, Tindaro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Erspamer, Vittorio</au><au>Melchiorri, Pietro</au><au>Broccardo, Maria</au><au>Erspamer, Giuliana Falconieri</au><au>Falaschi, Paolo</au><au>Improta, Giovanna</au><au>Negri, Lucia</au><au>Renda, Tindaro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The brain-gut-skin triangle: New peptides</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>1981</date><risdate>1981</risdate><volume>2</volume><spage>7</spage><epage>16</epage><pages>7-16</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><abstract>New data on tachykinins and bombesins are displayed and the present situation of research on the novel amphibian skin peptides sauvagine and dermorphin is illustrated. The potent stimulant effect of sauvagine on ACTH and β-endorphin release has been confirmed both in vivo and on columns of isolated and dispersed rat pituitary cells, and similarly the potent inhibitory effect on PRL and GH release, both in the rat and man. Particular emphasis is laid on the occurrence of sauvagine-like immunoreactivity in fish urophysis and in amphibian nervous structures, including the retina. It is suggested that the long-searched corticotropin releasing factor and PRL release-inhibiting factor may be a sauvagine-like peptide. 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| fulltext | fulltext |
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| ispartof | Peptides (New York, N.Y. : 1980), 1981, Vol.2, p.7-16 |
| issn | 0196-9781 1873-5169 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adrenocorticotropic Hormone - metabolism Amino Acid Sequence Amphibian Proteins Analgesia Animals Behavior, Animal - physiology beta-Endorphin Bombesin - metabolism Bombesins Brain - metabolism Brain-gut-skin peptide triangle Dermorphins Digestive System - metabolism Endorphins - metabolism Gastric Acid - metabolism Gastric Emptying Hemodynamics Histocytochemistry Humans Muscle Contraction Muscle, Smooth - physiology Oligopeptides - physiology Opioid Peptides Peptide Hormones Peptides - physiology Pituitary Hormones, Anterior - metabolism Prolactin - metabolism Protein Conformation Sauvagine Sauvagine-like immunoreactivity Skin - metabolism Substance P - physiology Tachykinins |
| title | The brain-gut-skin triangle: New peptides |
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