Reduced O-glycosylated clathrin assembly protein AP180: implication for synaptic vesicle recycling dysfunction in Alzheimer's disease

Synapse loss is one of the neuropathologies in Alzheimer's disease (AD) that may play a crucial role in the mechanism of its distinct cognitive impairment and dementia. In a previous study [18], a significant reduction of O-glycosylated clathrin assembly protein AP180 was observed in neocortex...

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Veröffentlicht in:	Neuroscience letters 1998-08, Vol.252 (1), p.33-36
Hauptverfasser:	Yao, Pamela J, Coleman, Paul D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylglucosamine - analysis Acetylglucosamine - metabolism Adaptor Proteins, Vesicular Transport Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Biological and medical sciences Clathrin - metabolism Clathrin assembly protein AP180 Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Enzyme Inhibitors - metabolism Galactose - pharmacokinetics Glycosylation Humans Medical sciences Monomeric Clathrin Assembly Proteins N-acetylglucosamine (O-GlcNAc) Nerve Tissue Proteins - isolation & purification Nerve Tissue Proteins - metabolism Neurofibrillary Tangles - chemistry Neurofibrillary Tangles - metabolism Neurofilament Proteins - analysis Neurology O-glycosylation Phosphoproteins - isolation & purification Phosphoproteins - metabolism Precipitin Tests Synapses - chemistry Synapses - metabolism Synaptic vesicle recycling Synaptic Vesicles - chemistry Synaptic Vesicles - metabolism Synaptophysin Synaptophysin - analysis Tritium
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