Effects of high-dose methotrexate and leucovorin on murine hemopoietic stem cells

This study compares the effects of a high dose of methotrexate (HDMTX) to that of a high dose of methotrexate plus leucovorin protection on the hemopoietic stem cells in a murine model. C57BL X C3H F1 mice were treated with a single large bolus (500 mg/kg body weight) of methotrexate or with the sam...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1982-02, Vol.42 (2), p.530-534
Hauptverfasser:	Pannacciulli, I, Massa, G, Bogliolo, G, Ghio, R, Sobrero, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Cell Count - drug effects Bone Marrow - drug effects Bone Marrow - pathology Colony-Forming Units Assay Drug Administration Schedule Female Hematopoiesis - drug effects Hematopoietic Stem Cells - drug effects Leucovorin - administration & dosage Male Methotrexate - administration & dosage Mice Mice, Inbred Strains Spleen - drug effects Spleen - pathology Time Factors
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