A prospective cohort study of blood donors: methodological issues in the investigation of injuries and chronic diseases

Blood donors have made important contributions to research, most notably in cross-sectional seroprevalence studies. The proposed New Zealand Blood Donors Health Study is a prospective cohort study of 30,000 New Zealand donors designed to investigate the determinants of common injuries, cardiovascula...

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Veröffentlicht in:Australian and New Zealand journal of public health 1998-10, Vol.22 (5), p.578-582, Article 578
Hauptverfasser: Ameratunga, Shanthi N., Norton, Robyn N., MacMahon, Stephen W., Smith, Gordon S., Jackson, Rodney T., Currie, Rochelle, Langley, John D., Sharpe, Susan S., Cheng, Ada, Woodfield, D. Graeme
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container_end_page 582
container_issue 5
container_start_page 578
container_title Australian and New Zealand journal of public health
container_volume 22
creator Ameratunga, Shanthi N.
Norton, Robyn N.
MacMahon, Stephen W.
Smith, Gordon S.
Jackson, Rodney T.
Currie, Rochelle
Langley, John D.
Sharpe, Susan S.
Cheng, Ada
Woodfield, D. Graeme
description Blood donors have made important contributions to research, most notably in cross-sectional seroprevalence studies. The proposed New Zealand Blood Donors Health Study is a prospective cohort study of 30,000 New Zealand donors designed to investigate the determinants of common injuries, cardiovascular disease and cancer. While robust from an analytic perspective, the execution of prospective cohort studies in many settings is impeded by methodological, economic and organisational barriers. We examined the operational considerations of implementing a large-scale cohort study at a transfusion centre and evaluated measures taken to optimise data collection procedures. A pilot study of 1,000 participants revealed donor motivation to participate in this research was high (91% response rate). Comprehensive exposure data on lifestyle, behavioural and psychosocial factors were obtained from 95% of participants. Substantial heterogeneity in levels of potential risk factors was noted among respondents. Detailed dietary habit information and a study blood sample were obtained from 67% and 100% of participants, respectively. Study recruitment and baseline data collection was feasible during routine donor visits with minimal interruption to donor centre staff and procedures. We conclude the study design and characteristics of the regional donor program enhance the efficiency and significance of the proposed research.
doi_str_mv 10.1111/j.1467-842X.1998.tb01442.x
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subjects Adolescent
Adult
Aged
Blood
Blood & organ donations
Blood donors
Blood Donors - psychology
Blood Donors - statistics & numerical data
Blood pressure
Cancer
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - etiology
Chronic Disease
Chronic illnesses
Cohort analysis
Data collection
Disease
Epidemiology
Health care
Heterogeneity
Humans
Injuries
Injury analysis
Life Style
Longitudinal studies
Medical research
Methodological problems
Middle Aged
Mortality
Motivation
Neoplasms - etiology
New Zealand
Operations Research
Pilot Projects
Prospective Studies
Public health
Recruitment
Research Design
Respondents
Risk Factors
Serology
Wounds and Injuries - etiology
title A prospective cohort study of blood donors: methodological issues in the investigation of injuries and chronic diseases
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