A prospective cohort study of blood donors: methodological issues in the investigation of injuries and chronic diseases
Blood donors have made important contributions to research, most notably in cross-sectional seroprevalence studies. The proposed New Zealand Blood Donors Health Study is a prospective cohort study of 30,000 New Zealand donors designed to investigate the determinants of common injuries, cardiovascula...
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Veröffentlicht in: | Australian and New Zealand journal of public health 1998-10, Vol.22 (5), p.578-582, Article 578 |
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creator | Ameratunga, Shanthi N. Norton, Robyn N. MacMahon, Stephen W. Smith, Gordon S. Jackson, Rodney T. Currie, Rochelle Langley, John D. Sharpe, Susan S. Cheng, Ada Woodfield, D. Graeme |
description | Blood donors have made important contributions to research, most notably in cross-sectional seroprevalence studies. The proposed New Zealand Blood Donors Health Study is a prospective cohort study of 30,000 New Zealand donors designed to investigate the determinants of common injuries, cardiovascular disease and cancer. While robust from an analytic perspective, the execution of prospective cohort studies in many settings is impeded by methodological, economic and organisational barriers. We examined the operational considerations of implementing a large-scale cohort study at a transfusion centre and evaluated measures taken to optimise data collection procedures. A pilot study of 1,000 participants revealed donor motivation to participate in this research was high (91% response rate). Comprehensive exposure data on lifestyle, behavioural and psychosocial factors were obtained from 95% of participants. Substantial heterogeneity in levels of potential risk factors was noted among respondents. Detailed dietary habit information and a study blood sample were obtained from 67% and 100% of participants, respectively. Study recruitment and baseline data collection was feasible during routine donor visits with minimal interruption to donor centre staff and procedures. We conclude the study design and characteristics of the regional donor program enhance the efficiency and significance of the proposed research. |
doi_str_mv | 10.1111/j.1467-842X.1998.tb01442.x |
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Graeme</creator><creatorcontrib>Ameratunga, Shanthi N. ; Norton, Robyn N. ; MacMahon, Stephen W. ; Smith, Gordon S. ; Jackson, Rodney T. ; Currie, Rochelle ; Langley, John D. ; Sharpe, Susan S. ; Cheng, Ada ; Woodfield, D. Graeme</creatorcontrib><description>Blood donors have made important contributions to research, most notably in cross-sectional seroprevalence studies. The proposed New Zealand Blood Donors Health Study is a prospective cohort study of 30,000 New Zealand donors designed to investigate the determinants of common injuries, cardiovascular disease and cancer. While robust from an analytic perspective, the execution of prospective cohort studies in many settings is impeded by methodological, economic and organisational barriers. We examined the operational considerations of implementing a large-scale cohort study at a transfusion centre and evaluated measures taken to optimise data collection procedures. A pilot study of 1,000 participants revealed donor motivation to participate in this research was high (91% response rate). Comprehensive exposure data on lifestyle, behavioural and psychosocial factors were obtained from 95% of participants. Substantial heterogeneity in levels of potential risk factors was noted among respondents. Detailed dietary habit information and a study blood sample were obtained from 67% and 100% of participants, respectively. Study recruitment and baseline data collection was feasible during routine donor visits with minimal interruption to donor centre staff and procedures. We conclude the study design and characteristics of the regional donor program enhance the efficiency and significance of the proposed research.</description><identifier>ISSN: 1326-0200</identifier><identifier>EISSN: 1753-6405</identifier><identifier>DOI: 10.1111/j.1467-842X.1998.tb01442.x</identifier><identifier>PMID: 9744213</identifier><language>eng</language><publisher>Oxford, UK: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Aged ; Blood ; Blood & organ donations ; Blood donors ; Blood Donors - psychology ; Blood Donors - statistics & numerical data ; Blood pressure ; Cancer ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - etiology ; Chronic Disease ; Chronic illnesses ; Cohort analysis ; Data collection ; Disease ; Epidemiology ; Health care ; Heterogeneity ; Humans ; Injuries ; Injury analysis ; Life Style ; Longitudinal studies ; Medical research ; Methodological problems ; Middle Aged ; Mortality ; Motivation ; Neoplasms - etiology ; New Zealand ; Operations Research ; Pilot Projects ; Prospective Studies ; Public health ; Recruitment ; Research Design ; Respondents ; Risk Factors ; Serology ; Wounds and Injuries - etiology</subject><ispartof>Australian and New Zealand journal of public health, 1998-10, Vol.22 (5), p.578-582, Article 578</ispartof><rights>1998 Copyright 1998 THE AUTHORS.</rights><rights>1998. 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Graeme</creatorcontrib><title>A prospective cohort study of blood donors: methodological issues in the investigation of injuries and chronic diseases</title><title>Australian and New Zealand journal of public health</title><addtitle>Aust N Z J Public Health</addtitle><description>Blood donors have made important contributions to research, most notably in cross-sectional seroprevalence studies. The proposed New Zealand Blood Donors Health Study is a prospective cohort study of 30,000 New Zealand donors designed to investigate the determinants of common injuries, cardiovascular disease and cancer. While robust from an analytic perspective, the execution of prospective cohort studies in many settings is impeded by methodological, economic and organisational barriers. We examined the operational considerations of implementing a large-scale cohort study at a transfusion centre and evaluated measures taken to optimise data collection procedures. A pilot study of 1,000 participants revealed donor motivation to participate in this research was high (91% response rate). Comprehensive exposure data on lifestyle, behavioural and psychosocial factors were obtained from 95% of participants. Substantial heterogeneity in levels of potential risk factors was noted among respondents. Detailed dietary habit information and a study blood sample were obtained from 67% and 100% of participants, respectively. Study recruitment and baseline data collection was feasible during routine donor visits with minimal interruption to donor centre staff and procedures. We conclude the study design and characteristics of the regional donor program enhance the efficiency and significance of the proposed research.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Blood</subject><subject>Blood & organ donations</subject><subject>Blood donors</subject><subject>Blood Donors - psychology</subject><subject>Blood Donors - statistics & numerical data</subject><subject>Blood pressure</subject><subject>Cancer</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Chronic Disease</subject><subject>Chronic illnesses</subject><subject>Cohort analysis</subject><subject>Data collection</subject><subject>Disease</subject><subject>Epidemiology</subject><subject>Health care</subject><subject>Heterogeneity</subject><subject>Humans</subject><subject>Injuries</subject><subject>Injury analysis</subject><subject>Life Style</subject><subject>Longitudinal studies</subject><subject>Medical research</subject><subject>Methodological problems</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Motivation</subject><subject>Neoplasms - etiology</subject><subject>New Zealand</subject><subject>Operations Research</subject><subject>Pilot Projects</subject><subject>Prospective Studies</subject><subject>Public health</subject><subject>Recruitment</subject><subject>Research Design</subject><subject>Respondents</subject><subject>Risk Factors</subject><subject>Serology</subject><subject>Wounds and Injuries - etiology</subject><issn>1326-0200</issn><issn>1753-6405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7TQ</sourceid><recordid>eNqVkk1v1DAQhiMEKqXwE5AskBCXLP5I7KSXstpCi1SVShSBuFiOPel6ycaL7Wx3_z0Ou-qhByi-jDV-5p0Zvc6yVwRPSDrvFhNScJFXBf0-IXVdTWKDSVHQyeZRdkhEyXJe4PJxujPKc0wxfpo9C2GBMSYpdZAd1CLhhB1mt1O08i6sQEe7BqTd3PmIQhzMFrkWNZ1zBhnXOx-O0RLi3BnXuRurVYdsCAMEZHsU55DCGkK0Nypa14-1tl8M3iZA9QbpuXe91cjYACpAeJ49aVUX4MU-HmVfP364np3nF5_PPs2mF7nmhFU5UVphxYpKVdQYRoDjqlFt2zDDG6VEUyrclAyAGkoagesWCOZlabSqeUqxo-zNTjdt-StNG-XSBg1dp3pwQ5CC1YwWZfFPkJIkTGqawLd_BUlVk0oQweuEvr6HLtzg-7SvZJhzTGjNR8HjHaWTEcFDK1feLpXfSoLl6LdcyNFvOfotR7_l3m-5ScUv9y2GZgnmrnRvcHp_f09c2_jHouiV7R7W4mQncWs72P7HcHL64-q8FFVSyHcKNkTY3Cko_1NywUQpv12eyWs2uxT89Iu8Svzpjof0M9YWvAzaQq_BWJ8-qjTOPmTw35Or9wo</recordid><startdate>199810</startdate><enddate>199810</enddate><creator>Ameratunga, Shanthi N.</creator><creator>Norton, Robyn N.</creator><creator>MacMahon, Stephen W.</creator><creator>Smith, Gordon S.</creator><creator>Jackson, Rodney T.</creator><creator>Currie, Rochelle</creator><creator>Langley, John D.</creator><creator>Sharpe, Susan S.</creator><creator>Cheng, Ada</creator><creator>Woodfield, D. 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Graeme</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A prospective cohort study of blood donors: methodological issues in the investigation of injuries and chronic diseases</atitle><jtitle>Australian and New Zealand journal of public health</jtitle><addtitle>Aust N Z J Public Health</addtitle><date>1998-10</date><risdate>1998</risdate><volume>22</volume><issue>5</issue><spage>578</spage><epage>582</epage><pages>578-582</pages><artnum>578</artnum><issn>1326-0200</issn><eissn>1753-6405</eissn><abstract>Blood donors have made important contributions to research, most notably in cross-sectional seroprevalence studies. The proposed New Zealand Blood Donors Health Study is a prospective cohort study of 30,000 New Zealand donors designed to investigate the determinants of common injuries, cardiovascular disease and cancer. While robust from an analytic perspective, the execution of prospective cohort studies in many settings is impeded by methodological, economic and organisational barriers. We examined the operational considerations of implementing a large-scale cohort study at a transfusion centre and evaluated measures taken to optimise data collection procedures. A pilot study of 1,000 participants revealed donor motivation to participate in this research was high (91% response rate). Comprehensive exposure data on lifestyle, behavioural and psychosocial factors were obtained from 95% of participants. Substantial heterogeneity in levels of potential risk factors was noted among respondents. Detailed dietary habit information and a study blood sample were obtained from 67% and 100% of participants, respectively. Study recruitment and baseline data collection was feasible during routine donor visits with minimal interruption to donor centre staff and procedures. We conclude the study design and characteristics of the regional donor program enhance the efficiency and significance of the proposed research.</abstract><cop>Oxford, UK</cop><pub>Elsevier B.V</pub><pmid>9744213</pmid><doi>10.1111/j.1467-842X.1998.tb01442.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adolescent Adult Aged Blood Blood & organ donations Blood donors Blood Donors - psychology Blood Donors - statistics & numerical data Blood pressure Cancer Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - etiology Chronic Disease Chronic illnesses Cohort analysis Data collection Disease Epidemiology Health care Heterogeneity Humans Injuries Injury analysis Life Style Longitudinal studies Medical research Methodological problems Middle Aged Mortality Motivation Neoplasms - etiology New Zealand Operations Research Pilot Projects Prospective Studies Public health Recruitment Research Design Respondents Risk Factors Serology Wounds and Injuries - etiology |
title | A prospective cohort study of blood donors: methodological issues in the investigation of injuries and chronic diseases |
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