TNF-α converting enzyme (TACE) is inhibited by TIMP-3

TNF-α converting enzyme (TACE; ADAM-17) is a membrane-bound disintegrin metalloproteinase that processes the membrane-associated cytokine proTNF-α to a soluble form. Because of its putative involvement in inflammatory diseases, TACE represents a significant target for the design of specific syntheti...

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Veröffentlicht in:	FEBS letters 1998-09, Vol.435 (1), p.39-44
Hauptverfasser:	Amour, Augustin, Slocombe, Patrick M, Webster, Ailsa, Butler, Michael, Knight, C.Graham, Smith, Bryan J, Stephens, Paul E, Shelley, Chris, Hutton, Mike, Knäuper, Vera, Docherty, Andrew J.P, Murphy, Gillian
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins ADAM17 Protein Amino Acid Sequence Animals Catalysis Disintegrin metalloproteinase Disintegrins - antagonists & inhibitors DMSO, dimethylsulfoxide Dnp, 2,4-dinitrophenyl Enzyme Inhibitors - pharmacology Fmoc, 9-fluorenylmethoxycarbonyl HATU, N-[(dimethylamino)-1H-1,2,3-triazolo[4,5b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide HOAt, 7-aza-1-hydroxybenzotriazole HPLC, high performance liquid chromatography Humans Hydrolysis Mca, (7-methoxycoumarin-4-yl)acetyl Metalloendopeptidases - antagonists & inhibitors Metalloendopeptidases - genetics Metalloendopeptidases - isolation & purification Metalloproteinase Mice NS0, Non-secretor zero PAL, peptide amide linker PEG, poly(ethylene glycol) PS, polystyrene PVDF, polyvinylidene difluoride Rats Recombinant Proteins - isolation & purification Recombinant Proteins - metabolism SDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresis Substrate Specificity TFA, trifluoroacetic acid Tissue Inhibitor of Metalloproteinase-3 - antagonists & inhibitors Tissue Inhibitor of Metalloproteinase-3 - pharmacology Tissue inhibitor of metalloproteinases TNF-α converting enzyme Tumor Necrosis Factor-alpha - metabolism Tumour necrosis factor
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