Early Benefit of Implantable Cardioverter Defibrillator Therapy in Patients Waiting for Cardiac Transplantation
The ICD can effectively recognize and treat ventricular arrhythmias that can lead to sudden death. Sudden death is a major problem in patients awaiting heart transplantation. We reviewed our experience with the ICD in patients with malignant ventricular arrhythmias waiting for cardiac transplantatio...
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| Veröffentlicht in: | Pacing and clinical electrophysiology 1998-09, Vol.21 (9), p.1747-1750 |
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| container_title | Pacing and clinical electrophysiology |
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| creator | LORGA-FILHO, ADALBERTO GEELEN, PETER VANDERHEYDEN, MARC MALACKY, TIBOR PRIMO, JOAO GOETHALS, MARC WELLENS, FRANCIS BRUGADA, PEDRO |
| description | The ICD can effectively recognize and treat ventricular arrhythmias that can lead to sudden death. Sudden death is a major problem in patients awaiting heart transplantation. We reviewed our experience with the ICD in patients with malignant ventricular arrhythmias waiting for cardiac transplantation. Nineteen patients were included. Seventeen were men, mean age was 54 ±11 years (range 17–66) and the left ventricular ejection fraction was 22%± 10% (range 9%–46%). After a mean follow–up of 6 ± 5 months (range 1–20 months), 17 patients reached heart transplantation. One patient died and the other is waiting for a transplant. Before transplantation 71 % of patients received an appropriate discharge. The mean time to the first appropriate discharge was 2 ± 2 months (range < 1–6 months), which was significantly shorter than the mean time to first discharge in the other patients (n = 182) receiving a defibrillator in our center (11 ±10 months; range 1–58 months) (P < 0.0004). In conclusion, cardiac transplantation candidates with life–threatening ventricular arrhythmias can effectively be protected against sudden arrhythmic death by ICD. These patients have a high incidence of appropriate shocks occurring very early after implantation. |
| doi_str_mv | 10.1111/j.1540-8159.1998.tb00274.x |
| format | Article |
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Sudden death is a major problem in patients awaiting heart transplantation. We reviewed our experience with the ICD in patients with malignant ventricular arrhythmias waiting for cardiac transplantation. Nineteen patients were included. Seventeen were men, mean age was 54 ±11 years (range 17–66) and the left ventricular ejection fraction was 22%± 10% (range 9%–46%). After a mean follow–up of 6 ± 5 months (range 1–20 months), 17 patients reached heart transplantation. One patient died and the other is waiting for a transplant. Before transplantation 71 % of patients received an appropriate discharge. The mean time to the first appropriate discharge was 2 ± 2 months (range < 1–6 months), which was significantly shorter than the mean time to first discharge in the other patients (n = 182) receiving a defibrillator in our center (11 ±10 months; range 1–58 months) (P < 0.0004). In conclusion, cardiac transplantation candidates with life–threatening ventricular arrhythmias can effectively be protected against sudden arrhythmic death by ICD. These patients have a high incidence of appropriate shocks occurring very early after implantation.</description><identifier>ISSN: 0147-8389</identifier><identifier>EISSN: 1540-8159</identifier><identifier>DOI: 10.1111/j.1540-8159.1998.tb00274.x</identifier><identifier>PMID: 9744438</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; cardiac transplantation ; Death, Sudden, Cardiac - prevention & control ; Defibrillators, Implantable ; Female ; Heart Transplantation - physiology ; Humans ; implantable Cardioverter defibrillator ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Stroke Volume - physiology ; sudden death ; Tachycardia, Ventricular - physiopathology ; Tachycardia, Ventricular - prevention & control ; Treatment Outcome ; ventricular arrhythmia ; Ventricular Fibrillation - physiopathology ; Ventricular Fibrillation - prevention & control ; Ventricular Function, Left - physiology ; Waiting Lists</subject><ispartof>Pacing and clinical electrophysiology, 1998-09, Vol.21 (9), p.1747-1750</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4097-80644bddae283522db39ead8e0836d0cf92a772d6307ed62af1506989c9d74b03</citedby><cites>FETCH-LOGICAL-c4097-80644bddae283522db39ead8e0836d0cf92a772d6307ed62af1506989c9d74b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1540-8159.1998.tb00274.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1540-8159.1998.tb00274.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9744438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LORGA-FILHO, ADALBERTO</creatorcontrib><creatorcontrib>GEELEN, PETER</creatorcontrib><creatorcontrib>VANDERHEYDEN, MARC</creatorcontrib><creatorcontrib>MALACKY, TIBOR</creatorcontrib><creatorcontrib>PRIMO, JOAO</creatorcontrib><creatorcontrib>GOETHALS, MARC</creatorcontrib><creatorcontrib>WELLENS, FRANCIS</creatorcontrib><creatorcontrib>BRUGADA, PEDRO</creatorcontrib><title>Early Benefit of Implantable Cardioverter Defibrillator Therapy in Patients Waiting for Cardiac Transplantation</title><title>Pacing and clinical electrophysiology</title><addtitle>Pacing Clin Electrophysiol</addtitle><description>The ICD can effectively recognize and treat ventricular arrhythmias that can lead to sudden death. Sudden death is a major problem in patients awaiting heart transplantation. We reviewed our experience with the ICD in patients with malignant ventricular arrhythmias waiting for cardiac transplantation. Nineteen patients were included. Seventeen were men, mean age was 54 ±11 years (range 17–66) and the left ventricular ejection fraction was 22%± 10% (range 9%–46%). After a mean follow–up of 6 ± 5 months (range 1–20 months), 17 patients reached heart transplantation. One patient died and the other is waiting for a transplant. Before transplantation 71 % of patients received an appropriate discharge. The mean time to the first appropriate discharge was 2 ± 2 months (range < 1–6 months), which was significantly shorter than the mean time to first discharge in the other patients (n = 182) receiving a defibrillator in our center (11 ±10 months; range 1–58 months) (P < 0.0004). In conclusion, cardiac transplantation candidates with life–threatening ventricular arrhythmias can effectively be protected against sudden arrhythmic death by ICD. These patients have a high incidence of appropriate shocks occurring very early after implantation.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>cardiac transplantation</subject><subject>Death, Sudden, Cardiac - prevention & control</subject><subject>Defibrillators, Implantable</subject><subject>Female</subject><subject>Heart Transplantation - physiology</subject><subject>Humans</subject><subject>implantable Cardioverter defibrillator</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Stroke Volume - physiology</subject><subject>sudden death</subject><subject>Tachycardia, Ventricular - physiopathology</subject><subject>Tachycardia, Ventricular - prevention & control</subject><subject>Treatment Outcome</subject><subject>ventricular arrhythmia</subject><subject>Ventricular Fibrillation - physiopathology</subject><subject>Ventricular Fibrillation - prevention & control</subject><subject>Ventricular Function, Left - physiology</subject><subject>Waiting Lists</subject><issn>0147-8389</issn><issn>1540-8159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMGO0zAQhi0EWsrCIyBZHLgljGMntjmx25ZlxQJ7KOzRcuIJuKRJsV1o356UVL3jyxz-fz6PPkJeMcjZ-N6sc1YKyBQrdc60VnmqAQop8v0jMjtHj8kMmJCZ4ko_Jc9iXANABaK8IBdaCiG4mpFhaUN3oNfYY-sTHVp6u9l2tk-27pDObXB--I0hYaCLsVEH33U2DYGufmCw2wP1Pb23yWOfIn2wPvn-O23H_N-qbegq2D5OxOSH_jl50tou4ovTvCRf3y9X8w_Z3Zeb2_nVXdYI0OPNUAlRO2exULwsCldzjdYpBMUrB02rCytl4SoOEl1V2JaVUGmlG-2kqIFfktcTdxuGXzuMyWx8bHA8vsdhF43kmrNSFWPx7VRswhBjwNZsg9_YcDAMzNG2WZujUnNUao62zcm22Y_LL0-_7OoNuvPqSe-Yv5vyP77Dw3-Qzf3VfMmkkCMimxA-JtyfETb8NJXksjQPn2_MpxX_-E3Cwiz4X_a_oIw</recordid><startdate>199809</startdate><enddate>199809</enddate><creator>LORGA-FILHO, ADALBERTO</creator><creator>GEELEN, PETER</creator><creator>VANDERHEYDEN, MARC</creator><creator>MALACKY, TIBOR</creator><creator>PRIMO, JOAO</creator><creator>GOETHALS, MARC</creator><creator>WELLENS, FRANCIS</creator><creator>BRUGADA, PEDRO</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199809</creationdate><title>Early Benefit of Implantable Cardioverter Defibrillator Therapy in Patients Waiting for Cardiac Transplantation</title><author>LORGA-FILHO, ADALBERTO ; GEELEN, PETER ; VANDERHEYDEN, MARC ; MALACKY, TIBOR ; PRIMO, JOAO ; GOETHALS, MARC ; WELLENS, FRANCIS ; BRUGADA, PEDRO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4097-80644bddae283522db39ead8e0836d0cf92a772d6307ed62af1506989c9d74b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>cardiac transplantation</topic><topic>Death, Sudden, Cardiac - prevention & control</topic><topic>Defibrillators, Implantable</topic><topic>Female</topic><topic>Heart Transplantation - physiology</topic><topic>Humans</topic><topic>implantable Cardioverter defibrillator</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Stroke Volume - physiology</topic><topic>sudden death</topic><topic>Tachycardia, Ventricular - physiopathology</topic><topic>Tachycardia, Ventricular - prevention & control</topic><topic>Treatment Outcome</topic><topic>ventricular arrhythmia</topic><topic>Ventricular Fibrillation - physiopathology</topic><topic>Ventricular Fibrillation - prevention & control</topic><topic>Ventricular Function, Left - physiology</topic><topic>Waiting Lists</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LORGA-FILHO, ADALBERTO</creatorcontrib><creatorcontrib>GEELEN, PETER</creatorcontrib><creatorcontrib>VANDERHEYDEN, MARC</creatorcontrib><creatorcontrib>MALACKY, TIBOR</creatorcontrib><creatorcontrib>PRIMO, JOAO</creatorcontrib><creatorcontrib>GOETHALS, MARC</creatorcontrib><creatorcontrib>WELLENS, FRANCIS</creatorcontrib><creatorcontrib>BRUGADA, PEDRO</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pacing and clinical electrophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LORGA-FILHO, ADALBERTO</au><au>GEELEN, PETER</au><au>VANDERHEYDEN, MARC</au><au>MALACKY, TIBOR</au><au>PRIMO, JOAO</au><au>GOETHALS, MARC</au><au>WELLENS, FRANCIS</au><au>BRUGADA, PEDRO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early Benefit of Implantable Cardioverter Defibrillator Therapy in Patients Waiting for Cardiac Transplantation</atitle><jtitle>Pacing and clinical electrophysiology</jtitle><addtitle>Pacing Clin Electrophysiol</addtitle><date>1998-09</date><risdate>1998</risdate><volume>21</volume><issue>9</issue><spage>1747</spage><epage>1750</epage><pages>1747-1750</pages><issn>0147-8389</issn><eissn>1540-8159</eissn><abstract>The ICD can effectively recognize and treat ventricular arrhythmias that can lead to sudden death. Sudden death is a major problem in patients awaiting heart transplantation. We reviewed our experience with the ICD in patients with malignant ventricular arrhythmias waiting for cardiac transplantation. Nineteen patients were included. Seventeen were men, mean age was 54 ±11 years (range 17–66) and the left ventricular ejection fraction was 22%± 10% (range 9%–46%). After a mean follow–up of 6 ± 5 months (range 1–20 months), 17 patients reached heart transplantation. One patient died and the other is waiting for a transplant. Before transplantation 71 % of patients received an appropriate discharge. The mean time to the first appropriate discharge was 2 ± 2 months (range < 1–6 months), which was significantly shorter than the mean time to first discharge in the other patients (n = 182) receiving a defibrillator in our center (11 ±10 months; range 1–58 months) (P < 0.0004). In conclusion, cardiac transplantation candidates with life–threatening ventricular arrhythmias can effectively be protected against sudden arrhythmic death by ICD. These patients have a high incidence of appropriate shocks occurring very early after implantation.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9744438</pmid><doi>10.1111/j.1540-8159.1998.tb00274.x</doi><tpages>4</tpages></addata></record> |
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| ispartof | Pacing and clinical electrophysiology, 1998-09, Vol.21 (9), p.1747-1750 |
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| source | MEDLINE; Wiley Journals |
| subjects | Adolescent Adult Aged cardiac transplantation Death, Sudden, Cardiac - prevention & control Defibrillators, Implantable Female Heart Transplantation - physiology Humans implantable Cardioverter defibrillator Male Middle Aged Retrospective Studies Risk Factors Stroke Volume - physiology sudden death Tachycardia, Ventricular - physiopathology Tachycardia, Ventricular - prevention & control Treatment Outcome ventricular arrhythmia Ventricular Fibrillation - physiopathology Ventricular Fibrillation - prevention & control Ventricular Function, Left - physiology Waiting Lists |
| title | Early Benefit of Implantable Cardioverter Defibrillator Therapy in Patients Waiting for Cardiac Transplantation |
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