Concurrent Sickle-Cell Anemia and α-Thalassemia: Effect on Severity of Anemia

We studied 47 patients with sickle-cell anemia to determine the effect of α-thalassemia on the severity of their hemolytic anemia. We diagnosed α-thalassemia objectively by using α-globin-gene mapping to detect α-globin-gene deletions, studying 25 subjects with the normal four α-globin genes, 18 wit...

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Veröffentlicht in:	The New England journal of medicine 1982-02, Vol.306 (5), p.270-274
Hauptverfasser:	Embury, Stephen H, Dozy, Andree M, Miller, Judy, Davis, J. R, Kleman, Klara M, Preisler, Haiganoush, Vichinsky, Elliott, Lande, William N, Lubin, Bertram H, Kan, Y. W, Mentzer, William C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Factors Anemia, Sickle Cell - blood Anemia, Sickle Cell - complications Anemia, Sickle Cell - genetics Child Child, Preschool Erythrocyte Count Fetal Hemoglobin - analysis Genes Globins - genetics Hematocrit Hemoglobin A2 - analysis Hemoglobins - analysis Hemolysis Humans Reticulocytes Thalassemia - blood Thalassemia - complications Thalassemia - genetics
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