An asymmetric deuterium labeling strategy to identify interprotomer and intraprotomer NOEs in oligomeric proteins

A major difficulty in determining the structure of an oligomeric protein by NMR is the problem of distinguishing inter- from intraprotomer NOEs. In order to address this issue in studies of the 27 kD compact trimeric domain of the MHC class II-associated invariant chain, we compared the 13C NOESY-HS...

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Veröffentlicht in:	Journal of biomolecular NMR 1998-08, Vol.12 (2), p.299-306
1. Verfasser:	Jasanoff, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Differentiation, B-Lymphocyte - chemistry Antigens, Differentiation, B-Lymphocyte - genetics Deuterium Escherichia coli - genetics Histocompatibility Antigens Class II - chemistry Histocompatibility Antigens Class II - genetics Humans Magnetic Resonance Spectroscopy - methods Peptide Fragments - chemistry Peptide Fragments - genetics Protein Conformation Proteins - chemistry Recombinant Proteins - chemistry Recombinant Proteins - genetics
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