p130, p107, and pRb Are Differentially Regulated in Proliferating Cells and during Cell Cycle Arrest by α-Interferon

We have determined how the phosphorylation of the retinoblastoma family (pRb, p107, and p130) is governed in individual cell cycle phases of Daudi B-cells during cell cycle exit triggered by α-interferon (α-IFN). α-IFN causes dephosphorylation of pRb and loss of p130 phosphorylated Form 3. However,...

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Veröffentlicht in:	The Journal of biological chemistry 1998-09, Vol.273 (37), p.23659-23667
Hauptverfasser:	Thomas, Nicholas S.B., Pizzey, Arnold R., Tiwari, Sanjay, Williams, Catherine D., Yang, Jiewu
Format:	Artikel
Sprache:	eng
Schlagworte:	B-Lymphocytes - cytology B-Lymphocytes - drug effects B-Lymphocytes - metabolism Base Sequence Binding Sites Carrier Proteins Cell Cycle - drug effects Cell Cycle - physiology Cell Cycle Proteins Cell Division Cells, Cultured DNA-Binding Proteins - metabolism E2F Transcription Factors E2F1 Transcription Factor E2F4 Transcription Factor Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - metabolism Humans Interferon-alpha - pharmacology Interferon-alpha - physiology Nuclear Proteins - metabolism Oligodeoxyribonucleotides - chemistry Oligodeoxyribonucleotides - metabolism Phosphoproteins - metabolism Phosphorylation Proteins Retinoblastoma Protein - metabolism Retinoblastoma-Binding Protein 1 Retinoblastoma-Like Protein p107 Retinoblastoma-Like Protein p130 T-Lymphocytes - cytology T-Lymphocytes - drug effects T-Lymphocytes - metabolism Transcription Factor DP1 Transcription Factors - metabolism Tretinoin - pharmacology Tumor Cells, Cultured
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