Overexpanded B cell clone mediating leukemic arthritis by abundant secretion of interleukin-1beta: a case report

The role of cytokines in leukemic arthritis is unknown. The presentation of a patient with B cell chronic lymphocytic leukemia and destructive arthritis of the wrist joints prompted us to study the synovial cytokine pattern by immunohistologic analysis. In addition, rearranged V(H) and V(L) immunogl...

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Veröffentlicht in:	Arthritis and rheumatism 1998-09, Vol.41 (9), p.1695-1700
Hauptverfasser:	Rudwaleit, M, Elias, F, Humaljoki, T, Neure, L, Knauf, W, Stein, H, Distler, A, Sieper, J, Berek, C, Braun, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Arthritis - immunology Arthritis - metabolism Arthritis - pathology B-Lymphocytes - immunology B-Lymphocytes - metabolism Base Sequence Clone Cells - secretion Cytokines - metabolism DNA Primers - chemistry DNA, Neoplasm - analysis Gene Rearrangement Genes, Immunoglobulin - genetics Humans Immunoenzyme Techniques Interleukin-1 - secretion Leukemia, Lymphocytic, Chronic, B-Cell - immunology Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Leukemia, Lymphocytic, Chronic, B-Cell - pathology Male Middle Aged Molecular Sequence Data Synovial Membrane - metabolism Synovial Membrane - pathology Wrist Joint - pathology
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