Tamoxifen and metabolites in MCF7 cells: correlation between binding to estrogen receptor and inhibition of cell growth

The binding of [3H]tamoxifen ([3H]Tam), a nonsteroidal antiestrogen, and of 4-[3H]hydroxytamoxifen ([3H]OH-Tam), a metabolite accumulated in vivo in target cell nuclei, was characterized in soluble extracts of human breast cancer MCF7 cells growing in a medium depleted in estrogens. Saturation analy...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1982-01, Vol.42 (1), p.317-323
Hauptverfasser:	Coezy, E, Borgna, J L, Rochefort, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Biotransformation Breast Neoplasms - metabolism Cell Division - drug effects Cell Line Female Humans Receptors, Estrogen - metabolism Structure-Activity Relationship Tamoxifen - analogs & derivatives Tamoxifen - metabolism Tamoxifen - pharmacology
Online-Zugang:	Volltext
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