Long‐term detection of microchimaerism in peripheral blood after pretransplantation blood transfusion
Renal allograft survival is prolonged after pretransplantation blood transfusion. The aim of this study was to test retrospectively the development and persistence of microchimaerism after pretransplantation blood transfusion and to assess whether the type of blood transfusion (partially matched [= ...
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| Veröffentlicht in: | British journal of haematology 1998-09, Vol.102 (4), p.1004-1009 |
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| creator | Vervoordeldonk, Susan F. Doumaid, Karim Remmerswaal, Ester B. M. Ten Berge, Ineke J. M. Wilmink, Joep M. DE Waal, Leo P. Boog, Claire J. P. |
| description | Renal allograft survival is prolonged after pretransplantation blood transfusion. The aim of this study was to test retrospectively the development and persistence of microchimaerism after pretransplantation blood transfusion and to assess whether the type of blood transfusion (partially matched [= sharing of at least one HLA‐B and one HLA‐DR antigen between blood donor and recipient] versus mismatched) influences the (continued) presence of donor‐type cells. A sensitive nested PCR technique based on HLA‐DRB1 allele‐specific amplification using sequence‐specific primers (detection level: one donor cell among 105 recipient cells) for detection of donor cells was implemented in our laboratory. We studied 21 patients for microchimaerism in the peripheral blood compartment, following blood transfusion. Our preliminary data show that microchimaerism was detectable up to 8 weeks after blood transfusion. In all patients receiving a partially matched blood transfusion, donor‐type cells were detected in the first week after transfusion, in 7/8 patients 2–4 weeks after transfusion, and in some patients up to 8 weeks after transfusion. After mismatched transfusion a tendency to shorter duration of microchimaerism was observed. |
| doi_str_mv | 10.1046/j.1365-2141.1998.00862.x |
| format | Article |
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M. ; Ten Berge, Ineke J. M. ; Wilmink, Joep M. ; DE Waal, Leo P. ; Boog, Claire J. P.</creator><creatorcontrib>Vervoordeldonk, Susan F. ; Doumaid, Karim ; Remmerswaal, Ester B. M. ; Ten Berge, Ineke J. M. ; Wilmink, Joep M. ; DE Waal, Leo P. ; Boog, Claire J. P.</creatorcontrib><description>Renal allograft survival is prolonged after pretransplantation blood transfusion. The aim of this study was to test retrospectively the development and persistence of microchimaerism after pretransplantation blood transfusion and to assess whether the type of blood transfusion (partially matched [= sharing of at least one HLA‐B and one HLA‐DR antigen between blood donor and recipient] versus mismatched) influences the (continued) presence of donor‐type cells. A sensitive nested PCR technique based on HLA‐DRB1 allele‐specific amplification using sequence‐specific primers (detection level: one donor cell among 105 recipient cells) for detection of donor cells was implemented in our laboratory. We studied 21 patients for microchimaerism in the peripheral blood compartment, following blood transfusion. Our preliminary data show that microchimaerism was detectable up to 8 weeks after blood transfusion. In all patients receiving a partially matched blood transfusion, donor‐type cells were detected in the first week after transfusion, in 7/8 patients 2–4 weeks after transfusion, and in some patients up to 8 weeks after transfusion. After mismatched transfusion a tendency to shorter duration of microchimaerism was observed.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1046/j.1365-2141.1998.00862.x</identifier><identifier>PMID: 9734651</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, U.K. and Cambridge, USA: Blackwell Publishers</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood Transfusion ; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis ; Chimera ; Female ; Hematology ; Histocompatibility Testing ; HLA matching ; HLA-DR3 Antigen - blood ; HLA-DR7 Antigen - blood ; Humans ; Kidney Transplantation ; Male ; Medical sciences ; microchimaerism ; PCR ; Polymerase Chain Reaction ; pre‐transplantation ; Retrospective Studies ; Time Factors ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><ispartof>British journal of haematology, 1998-09, Vol.102 (4), p.1004-1009</ispartof><rights>1998 Blackwell Science Ltd</rights><rights>1998 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Sep 1998</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4692-2581388a4a6ae8ffc25655c1d1c194ac32b88003e7f8d46e042bc2ca170465773</citedby><cites>FETCH-LOGICAL-c4692-2581388a4a6ae8ffc25655c1d1c194ac32b88003e7f8d46e042bc2ca170465773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2141.1998.00862.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2141.1998.00862.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46387,46811</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2363935$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9734651$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vervoordeldonk, Susan F.</creatorcontrib><creatorcontrib>Doumaid, Karim</creatorcontrib><creatorcontrib>Remmerswaal, Ester B. M.</creatorcontrib><creatorcontrib>Ten Berge, Ineke J. M.</creatorcontrib><creatorcontrib>Wilmink, Joep M.</creatorcontrib><creatorcontrib>DE Waal, Leo P.</creatorcontrib><creatorcontrib>Boog, Claire J. P.</creatorcontrib><title>Long‐term detection of microchimaerism in peripheral blood after pretransplantation blood transfusion</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Renal allograft survival is prolonged after pretransplantation blood transfusion. The aim of this study was to test retrospectively the development and persistence of microchimaerism after pretransplantation blood transfusion and to assess whether the type of blood transfusion (partially matched [= sharing of at least one HLA‐B and one HLA‐DR antigen between blood donor and recipient] versus mismatched) influences the (continued) presence of donor‐type cells. A sensitive nested PCR technique based on HLA‐DRB1 allele‐specific amplification using sequence‐specific primers (detection level: one donor cell among 105 recipient cells) for detection of donor cells was implemented in our laboratory. We studied 21 patients for microchimaerism in the peripheral blood compartment, following blood transfusion. Our preliminary data show that microchimaerism was detectable up to 8 weeks after blood transfusion. In all patients receiving a partially matched blood transfusion, donor‐type cells were detected in the first week after transfusion, in 7/8 patients 2–4 weeks after transfusion, and in some patients up to 8 weeks after transfusion. After mismatched transfusion a tendency to shorter duration of microchimaerism was observed.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood Transfusion</subject><subject>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</subject><subject>Chimera</subject><subject>Female</subject><subject>Hematology</subject><subject>Histocompatibility Testing</subject><subject>HLA matching</subject><subject>HLA-DR3 Antigen - blood</subject><subject>HLA-DR7 Antigen - blood</subject><subject>Humans</subject><subject>Kidney Transplantation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>microchimaerism</subject><subject>PCR</subject><subject>Polymerase Chain Reaction</subject><subject>pre‐transplantation</subject><subject>Retrospective Studies</subject><subject>Time Factors</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1TAQhS0EKpfCIyBZCLFL6n87EhuogFJdiU27tnwdu81VEgc7Udsdj8Az8iTM_dFdsGLl0ZxzxqNvEMKU1JQIdbGtKVeyYlTQmjaNqQkxitWPz9DqJDxHK0KIriBgXqJXpWwJoZxIeobOGs2FknSF7tZpvPvz6_cc8oDbMAc_d2nEKeKh8zn5-25wIXdlwN2IJ6im-5Bdjzd9Si12EXJ4ymHObixT78bZ7fMHed-NS4HOa_Qiur6EN8f3HN1-_XJzeVWtf3z7fvlpXXmhGlYxaSg3xgmnXDAxeiaVlJ621NNGOM_ZxhhCeNDRtEIFItjGM--oBipSa36OPhzmTjn9XEKZ7dAVH3pYLaSlWM0bRhtjwPjuH-M2LXmE3SzoUnMtGJjMwQQoSskh2ikDkPxkKbG7Q9it3fG2O952dwi7P4R9hOjb4_xlM4T2FDySB_39UXfFuz4CKt-Vk41xxRsuwfbxYHvo-vD039_bz9dXUPC_t5WlMg</recordid><startdate>199809</startdate><enddate>199809</enddate><creator>Vervoordeldonk, Susan F.</creator><creator>Doumaid, Karim</creator><creator>Remmerswaal, Ester B. M.</creator><creator>Ten Berge, Ineke J. M.</creator><creator>Wilmink, Joep M.</creator><creator>DE Waal, Leo P.</creator><creator>Boog, Claire J. P.</creator><general>Blackwell Publishers</general><general>Blackwell</general><general>Blackwell Publishing Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199809</creationdate><title>Long‐term detection of microchimaerism in peripheral blood after pretransplantation blood transfusion</title><author>Vervoordeldonk, Susan F. ; Doumaid, Karim ; Remmerswaal, Ester B. M. ; Ten Berge, Ineke J. M. ; Wilmink, Joep M. ; DE Waal, Leo P. ; Boog, Claire J. P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4692-2581388a4a6ae8ffc25655c1d1c194ac32b88003e7f8d46e042bc2ca170465773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood Transfusion</topic><topic>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</topic><topic>Chimera</topic><topic>Female</topic><topic>Hematology</topic><topic>Histocompatibility Testing</topic><topic>HLA matching</topic><topic>HLA-DR3 Antigen - blood</topic><topic>HLA-DR7 Antigen - blood</topic><topic>Humans</topic><topic>Kidney Transplantation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>microchimaerism</topic><topic>PCR</topic><topic>Polymerase Chain Reaction</topic><topic>pre‐transplantation</topic><topic>Retrospective Studies</topic><topic>Time Factors</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vervoordeldonk, Susan F.</creatorcontrib><creatorcontrib>Doumaid, Karim</creatorcontrib><creatorcontrib>Remmerswaal, Ester B. M.</creatorcontrib><creatorcontrib>Ten Berge, Ineke J. M.</creatorcontrib><creatorcontrib>Wilmink, Joep M.</creatorcontrib><creatorcontrib>DE Waal, Leo P.</creatorcontrib><creatorcontrib>Boog, Claire J. P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vervoordeldonk, Susan F.</au><au>Doumaid, Karim</au><au>Remmerswaal, Ester B. M.</au><au>Ten Berge, Ineke J. M.</au><au>Wilmink, Joep M.</au><au>DE Waal, Leo P.</au><au>Boog, Claire J. P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long‐term detection of microchimaerism in peripheral blood after pretransplantation blood transfusion</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>1998-09</date><risdate>1998</risdate><volume>102</volume><issue>4</issue><spage>1004</spage><epage>1009</epage><pages>1004-1009</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>Renal allograft survival is prolonged after pretransplantation blood transfusion. The aim of this study was to test retrospectively the development and persistence of microchimaerism after pretransplantation blood transfusion and to assess whether the type of blood transfusion (partially matched [= sharing of at least one HLA‐B and one HLA‐DR antigen between blood donor and recipient] versus mismatched) influences the (continued) presence of donor‐type cells. A sensitive nested PCR technique based on HLA‐DRB1 allele‐specific amplification using sequence‐specific primers (detection level: one donor cell among 105 recipient cells) for detection of donor cells was implemented in our laboratory. We studied 21 patients for microchimaerism in the peripheral blood compartment, following blood transfusion. Our preliminary data show that microchimaerism was detectable up to 8 weeks after blood transfusion. In all patients receiving a partially matched blood transfusion, donor‐type cells were detected in the first week after transfusion, in 7/8 patients 2–4 weeks after transfusion, and in some patients up to 8 weeks after transfusion. After mismatched transfusion a tendency to shorter duration of microchimaerism was observed.</abstract><cop>Oxford, U.K. and Cambridge, USA</cop><pub>Blackwell Publishers</pub><pmid>9734651</pmid><doi>10.1046/j.1365-2141.1998.00862.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of haematology, 1998-09, Vol.102 (4), p.1004-1009 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; EZB-FREE-00999 freely available EZB journals |
| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Transfusion Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Chimera Female Hematology Histocompatibility Testing HLA matching HLA-DR3 Antigen - blood HLA-DR7 Antigen - blood Humans Kidney Transplantation Male Medical sciences microchimaerism PCR Polymerase Chain Reaction pre‐transplantation Retrospective Studies Time Factors Transfusions. Complications. Transfusion reactions. Cell and gene therapy |
| title | Long‐term detection of microchimaerism in peripheral blood after pretransplantation blood transfusion |
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