Inhibition of eukaryote protein kinases and of a cyclic nucleotide-binding phosphatase by prenylated xanthones

A series of prenylated xanthones are variously potent inhibitors of the catalytic subunit (cAK) of rat liver cyclic AMP-dependent protein kinase (PKA), rat brain Ca 2+and phospholipid-dependent protein kinase C (PKC), chicken gizzard myosin light chain kinase (MLCK), wheat embryo Ca 2+-dependent pro...

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Veröffentlicht in:	Chemico-biological interactions 1998-07, Vol.114 (1), p.121-140
Hauptverfasser:	Lu, Zhe Xiong, Hasmeda, Mery, Mahabusarakam, Wilawan, Ternai, Bela, Ternai, Prapaipit Chamsuksai, Polya, Gideon M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Chickens Cyclic Nucleotide-Regulated Protein Kinases - antagonists & inhibitors Enzyme Inhibitors - pharmacology Gizzard, Avian - enzymology Myosin-Light-Chain Kinase - antagonists & inhibitors Phosphatase Prenylated xanthones Protein Kinase Inhibitors Protein Kinases Rats Solanum tuberosum - enzymology Structure-Activity Relationship Triticum - enzymology Xanthenes - chemistry Xanthenes - pharmacology Xanthones
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